The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes

Tetraspanins are transmembrane signaling and proinflammatory proteins. Prior work demonstrates that the tetraspanin, CD53/TSPAN25/MOX44, mediates B-cell development and lymphocyte migration to lymph nodes and is implicated in various inflammatory diseases. However, CD53 is also expressed in highly m...

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Veröffentlicht in:	The Journal of biological chemistry 2023-02, Vol.299 (2), p.102835, Article 102835
Hauptverfasser:	Higgins, Cassandra B., Adams, Joshua A., Ward, Matthew H., Greenberg, Zev J., Milewska, Małgorzata, Sun, Jiameng, Zhang, Yiming, Chiquetto Paracatu, Luana, Dong, Qian, Ballentine, Samuel, Li, Weikai, Wandzik, Ilona, Schuettpelz, Laura G., DeBosch, Brian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals caloric restriction CD53 Diet, High-Fat energy metabolism fasting FGF21 glucose transport GLUT Hepatocytes - metabolism Inflammation - genetics Inflammation - metabolism insulin resistance lactotrehalose Liver - metabolism Mice Mice, Inbred C57BL Non-alcoholic Fatty Liver Disease - metabolism nonalcoholic fatty liver disease obesity Obesity - metabolism proteomics tetraspanin Tetraspanin 25 - metabolism Tetraspanins - genetics Tetraspanins - metabolism thermogenesis trehalose Trehalose - metabolism
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