Positive zinc intake and a Japanese diet rich in n-3 fatty acids induces clinical remission in patients with mild active ulcerative colitis: a randomized interventional pilot study
Zinc intake has reduced hospitalizations in patients with ulcerative colitis (UC), highlighting the need to maintain blood zinc levels. This prospective study investigated whether the promotion of zinc intake and a Japanese diet (high in n-3 fatty acids) could induce clinical remission in patients w...
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| Veröffentlicht in: | Journal of Clinical Biochemistry and Nutrition 2023, Vol.72(1), pp.82-88 |
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| container_title | Journal of Clinical Biochemistry and Nutrition |
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| creator | Miyaguchi, Kazuya Tsuzuki, Yoshikazu Ichikawa, Yuka Shiomi, Rie Ohgo, Hideki Nakamoto, Hidetomo Imaeda, Hiroyuki |
| description | Zinc intake has reduced hospitalizations in patients with ulcerative colitis (UC), highlighting the need to maintain blood zinc levels. This prospective study investigated whether the promotion of zinc intake and a Japanese diet (high in n-3 fatty acids) could induce clinical remission in patients with mild active UC. Patients with mild active UC were randomly assigned to either (1) continue an unrestricted diet or (2) receive nutritional guidance promoting zinc intake and a Japanese diet. The primary endpoint was clinical remission at 24 weeks. Secondary endpoints were the Ulcerative Colitis Endoscopic Index of Severity (UCEIS) scores, Clinical Activity Index (CAI), Geboes Histopathology Score (GHS), and biomarkers, including zinc levels, measured at 12 and 24 weeks. Nutritional assessments were performed using the Food Frequency Questionnaire. The CAI, UCEIS, and GHS scores were significantly lower in the intervention group than in the control group, with a significantly higher proportion of patients achieving clinical remission. Furthermore, the intervention group exhibited weight gain and significantly increased blood zinc levels. The combination of promoting dietary zinc intake and a Japanese diet rich in n-3 fatty acids can induce clinical remission in patients with mild active UC. |
| doi_str_mv | 10.3164/jcbn.22-72 |
| format | Article |
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This prospective study investigated whether the promotion of zinc intake and a Japanese diet (high in n-3 fatty acids) could induce clinical remission in patients with mild active UC. Patients with mild active UC were randomly assigned to either (1) continue an unrestricted diet or (2) receive nutritional guidance promoting zinc intake and a Japanese diet. The primary endpoint was clinical remission at 24 weeks. Secondary endpoints were the Ulcerative Colitis Endoscopic Index of Severity (UCEIS) scores, Clinical Activity Index (CAI), Geboes Histopathology Score (GHS), and biomarkers, including zinc levels, measured at 12 and 24 weeks. Nutritional assessments were performed using the Food Frequency Questionnaire. The CAI, UCEIS, and GHS scores were significantly lower in the intervention group than in the control group, with a significantly higher proportion of patients achieving clinical remission. Furthermore, the intervention group exhibited weight gain and significantly increased blood zinc levels. The combination of promoting dietary zinc intake and a Japanese diet rich in n-3 fatty acids can induce clinical remission in patients with mild active UC.</description><identifier>ISSN: 0912-0009</identifier><identifier>EISSN: 1880-5086</identifier><identifier>DOI: 10.3164/jcbn.22-72</identifier><identifier>PMID: 36777083</identifier><language>eng</language><publisher>Japan: SOCIETY FOR FREE RADICAL RESEARCH JAPAN</publisher><subject>Biomarkers ; Blood ; Diet ; Dietary intake ; Fatty acids ; Histopathology ; Inflammatory bowel disease ; n-3 fatty acids ; Nutrition assessment ; Original ; Remission ; Remission (Medicine) ; Ulcerative colitis ; Zinc</subject><ispartof>Journal of Clinical Biochemistry and Nutrition, 2023, Vol.72(1), pp.82-88</ispartof><rights>2023 JCBN</rights><rights>Copyright © 2023 JCBN.</rights><rights>2023. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). 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Clin. Biochem. Nutr.</addtitle><description>Zinc intake has reduced hospitalizations in patients with ulcerative colitis (UC), highlighting the need to maintain blood zinc levels. This prospective study investigated whether the promotion of zinc intake and a Japanese diet (high in n-3 fatty acids) could induce clinical remission in patients with mild active UC. Patients with mild active UC were randomly assigned to either (1) continue an unrestricted diet or (2) receive nutritional guidance promoting zinc intake and a Japanese diet. The primary endpoint was clinical remission at 24 weeks. Secondary endpoints were the Ulcerative Colitis Endoscopic Index of Severity (UCEIS) scores, Clinical Activity Index (CAI), Geboes Histopathology Score (GHS), and biomarkers, including zinc levels, measured at 12 and 24 weeks. Nutritional assessments were performed using the Food Frequency Questionnaire. 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The combination of promoting dietary zinc intake and a Japanese diet rich in n-3 fatty acids can induce clinical remission in patients with mild active UC.</description><subject>Biomarkers</subject><subject>Blood</subject><subject>Diet</subject><subject>Dietary intake</subject><subject>Fatty acids</subject><subject>Histopathology</subject><subject>Inflammatory bowel disease</subject><subject>n-3 fatty acids</subject><subject>Nutrition assessment</subject><subject>Original</subject><subject>Remission</subject><subject>Remission (Medicine)</subject><subject>Ulcerative colitis</subject><subject>Zinc</subject><issn>0912-0009</issn><issn>1880-5086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdksuOFCEUhitG47SjGx_AkLgxJjVSQEHhwmgmXjOJLnRNKOrUNC0FLVBtep7LB5TqHjvqhtv5-M_P4VTV4wZf0IazFxvT-wtCakHuVKum63Dd4o7frVZYNqTGGMuz6kFKG4wZbzm7X51RLoTAHV1Vv76EZLPdAbqx3iDrs_4OSPsBafRJb7WHBGiwkFG0Zl3iyNcUjTrnPdLGDqkcDbOBhIyz3hrtUITJpmSDX-itzhZ8TuinzWs0WVeEzSHf7AxEfVia4IqH9LLkjCV1mOwNDIsXiLtyuUgV2a11IaOU52H_sLo3apfg0e18Xn179_br5Yf66vP7j5dvrmrTtjTXlOKu0T0ZoWVMNkK3kgDlUvQGc25MzwbTlq0hhDVU9gIYayUdcQ-il3yg59Wro-527icYTPEStVPbaCcd9ypoq_6NeLtW12GnZCelbLoi8OxWIIYfM6SsSmkMOFfqGuakiBCtbBkRrKBP_0M3YY7l4QvVcUGI4LRQz4-UiSGlCOPJTIPV0gxqaQZFiBKkwE_-tn9C__x-AV4fgU3K-hpOgI7ZGgdHLUFUswwHzVPIrHVU4OlvGsrLzg</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Miyaguchi, Kazuya</creator><creator>Tsuzuki, Yoshikazu</creator><creator>Ichikawa, Yuka</creator><creator>Shiomi, Rie</creator><creator>Ohgo, Hideki</creator><creator>Nakamoto, Hidetomo</creator><creator>Imaeda, Hiroyuki</creator><general>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</general><general>Japan Science and Technology Agency</general><general>the Society for Free Radical Research Japan</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230101</creationdate><title>Positive zinc intake and a Japanese diet rich in n-3 fatty acids induces clinical remission in patients with mild active ulcerative colitis: a randomized interventional pilot study</title><author>Miyaguchi, Kazuya ; Tsuzuki, Yoshikazu ; Ichikawa, Yuka ; Shiomi, Rie ; Ohgo, Hideki ; Nakamoto, Hidetomo ; Imaeda, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c553t-33081ab2fe544917a592e3697bc066ccb4dc5697c224139b7e44593f0be7b96d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biomarkers</topic><topic>Blood</topic><topic>Diet</topic><topic>Dietary intake</topic><topic>Fatty acids</topic><topic>Histopathology</topic><topic>Inflammatory bowel disease</topic><topic>n-3 fatty acids</topic><topic>Nutrition assessment</topic><topic>Original</topic><topic>Remission</topic><topic>Remission (Medicine)</topic><topic>Ulcerative colitis</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyaguchi, Kazuya</creatorcontrib><creatorcontrib>Tsuzuki, Yoshikazu</creatorcontrib><creatorcontrib>Ichikawa, Yuka</creatorcontrib><creatorcontrib>Shiomi, Rie</creatorcontrib><creatorcontrib>Ohgo, Hideki</creatorcontrib><creatorcontrib>Nakamoto, Hidetomo</creatorcontrib><creatorcontrib>Imaeda, Hiroyuki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyaguchi, Kazuya</au><au>Tsuzuki, Yoshikazu</au><au>Ichikawa, Yuka</au><au>Shiomi, Rie</au><au>Ohgo, Hideki</au><au>Nakamoto, Hidetomo</au><au>Imaeda, Hiroyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Positive zinc intake and a Japanese diet rich in n-3 fatty acids induces clinical remission in patients with mild active ulcerative colitis: a randomized interventional pilot study</atitle><jtitle>Journal of Clinical Biochemistry and Nutrition</jtitle><addtitle>J. Clin. Biochem. Nutr.</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>72</volume><issue>1</issue><spage>82</spage><epage>88</epage><pages>82-88</pages><artnum>22-72</artnum><issn>0912-0009</issn><eissn>1880-5086</eissn><abstract>Zinc intake has reduced hospitalizations in patients with ulcerative colitis (UC), highlighting the need to maintain blood zinc levels. This prospective study investigated whether the promotion of zinc intake and a Japanese diet (high in n-3 fatty acids) could induce clinical remission in patients with mild active UC. Patients with mild active UC were randomly assigned to either (1) continue an unrestricted diet or (2) receive nutritional guidance promoting zinc intake and a Japanese diet. The primary endpoint was clinical remission at 24 weeks. Secondary endpoints were the Ulcerative Colitis Endoscopic Index of Severity (UCEIS) scores, Clinical Activity Index (CAI), Geboes Histopathology Score (GHS), and biomarkers, including zinc levels, measured at 12 and 24 weeks. Nutritional assessments were performed using the Food Frequency Questionnaire. The CAI, UCEIS, and GHS scores were significantly lower in the intervention group than in the control group, with a significantly higher proportion of patients achieving clinical remission. Furthermore, the intervention group exhibited weight gain and significantly increased blood zinc levels. The combination of promoting dietary zinc intake and a Japanese diet rich in n-3 fatty acids can induce clinical remission in patients with mild active UC.</abstract><cop>Japan</cop><pub>SOCIETY FOR FREE RADICAL RESEARCH JAPAN</pub><pmid>36777083</pmid><doi>10.3164/jcbn.22-72</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers Blood Diet Dietary intake Fatty acids Histopathology Inflammatory bowel disease n-3 fatty acids Nutrition assessment Original Remission Remission (Medicine) Ulcerative colitis Zinc |
| title | Positive zinc intake and a Japanese diet rich in n-3 fatty acids induces clinical remission in patients with mild active ulcerative colitis: a randomized interventional pilot study |
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