Two cases of follicular lymphoma with MYC gene abnormalities that presented with bone marrow necrosis
Bone marrow necrosis (BMN) occurs most frequently in hematological malignancies and sometimes in non-hematological disorders. Lymphoid diseases causing necrosis are regarded as high-grade disease. B-lymphoblastic leukemia/lymphoma is the most common malignant cause of BMN. Here, we present two patie...
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| Veröffentlicht in: | Journal of Clinical and Experimental Hematopathology 2022, Vol.62(4), pp.208-216 |
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| creator | Miyazawa, Yuri Takei, Hisashi Kobayashi, Nobuhiko Akashi, Naoki Sairenji, Yukiko Sugisaki, Manato Naito, Chiaki Ishikawa, Tetsuya Shimizu, Hiroaki Ishizaki, Takuma Yokohama, Akihiko Tsukamoto, Norifumi Yoshida, Yuka Matsumura, Nozomi Takayama, Yoshiyasu Handa, Hiroshi |
| description | Bone marrow necrosis (BMN) occurs most frequently in hematological malignancies and sometimes in non-hematological disorders. Lymphoid diseases causing necrosis are regarded as high-grade disease. B-lymphoblastic leukemia/lymphoma is the most common malignant cause of BMN. Here, we present two patients with follicular lymphoma (FL) and MYC gene abnormalities who developed BMN. In one case of BMN, the necrosis disappeared in response to chemotherapy, and the patient survived with complete remission. In the other case, BMN remained even after chemotherapy, and effective chemotherapy could not be administered due to suppressed hematopoiesis, which led to the lymphoma worsening and the patient’s death. Indolent lymphomas, such as FL, as in these cases, have the potential to develop BMN. It is important to detect the development of BMN and administer chemotherapy early to improve patient prognosis, since severe BMN prevents patients from receiving effective treatment. |
| doi_str_mv | 10.3960/jslrt.22004 |
| format | Article |
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Lymphoid diseases causing necrosis are regarded as high-grade disease. B-lymphoblastic leukemia/lymphoma is the most common malignant cause of BMN. Here, we present two patients with follicular lymphoma (FL) and MYC gene abnormalities who developed BMN. In one case of BMN, the necrosis disappeared in response to chemotherapy, and the patient survived with complete remission. In the other case, BMN remained even after chemotherapy, and effective chemotherapy could not be administered due to suppressed hematopoiesis, which led to the lymphoma worsening and the patient’s death. Indolent lymphomas, such as FL, as in these cases, have the potential to develop BMN. It is important to detect the development of BMN and administer chemotherapy early to improve patient prognosis, since severe BMN prevents patients from receiving effective treatment.</description><identifier>ISSN: 1346-4280</identifier><identifier>EISSN: 1880-9952</identifier><identifier>DOI: 10.3960/jslrt.22004</identifier><identifier>PMID: 36261333</identifier><language>eng</language><publisher>Japan: The Japanese Society for Lymphoreticular Tissue Research</publisher><subject>Bone Marrow - pathology ; bone marrow necrosis ; Case Report ; follicular lymphoma ; Genes, myc ; hematopoiesis ; Humans ; Lymphoma, Follicular - drug therapy ; Lymphoma, Follicular - genetics ; Lymphoma, Follicular - pathology ; Lymphoma, Non-Hodgkin - pathology ; MYC abnormalities ; Necrosis - pathology</subject><ispartof>Journal of Clinical and Experimental Hematopathology, 2022, Vol.62(4), pp.208-216</ispartof><rights>2022 by The Japanese Society for Lymphoreticular Tissue Research</rights><rights>2022 by The Japanese Society for Lymphoreticular Tissue Research 2022 The Japanese Society for Lymphoreticular Tissue Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c487t-a0f97733b2d4def0da4cc6e09d4145c0d486329a8f0c8c4d8a118a564aff8c0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898713/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898713/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36261333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyazawa, Yuri</creatorcontrib><creatorcontrib>Takei, Hisashi</creatorcontrib><creatorcontrib>Kobayashi, Nobuhiko</creatorcontrib><creatorcontrib>Akashi, Naoki</creatorcontrib><creatorcontrib>Sairenji, Yukiko</creatorcontrib><creatorcontrib>Sugisaki, Manato</creatorcontrib><creatorcontrib>Naito, Chiaki</creatorcontrib><creatorcontrib>Ishikawa, Tetsuya</creatorcontrib><creatorcontrib>Shimizu, Hiroaki</creatorcontrib><creatorcontrib>Ishizaki, Takuma</creatorcontrib><creatorcontrib>Yokohama, Akihiko</creatorcontrib><creatorcontrib>Tsukamoto, Norifumi</creatorcontrib><creatorcontrib>Yoshida, Yuka</creatorcontrib><creatorcontrib>Matsumura, Nozomi</creatorcontrib><creatorcontrib>Takayama, Yoshiyasu</creatorcontrib><creatorcontrib>Handa, Hiroshi</creatorcontrib><title>Two cases of follicular lymphoma with MYC gene abnormalities that presented with bone marrow necrosis</title><title>Journal of Clinical and Experimental Hematopathology</title><addtitle>J Clin Exp Hematopathol</addtitle><description>Bone marrow necrosis (BMN) occurs most frequently in hematological malignancies and sometimes in non-hematological disorders. Lymphoid diseases causing necrosis are regarded as high-grade disease. B-lymphoblastic leukemia/lymphoma is the most common malignant cause of BMN. Here, we present two patients with follicular lymphoma (FL) and MYC gene abnormalities who developed BMN. In one case of BMN, the necrosis disappeared in response to chemotherapy, and the patient survived with complete remission. In the other case, BMN remained even after chemotherapy, and effective chemotherapy could not be administered due to suppressed hematopoiesis, which led to the lymphoma worsening and the patient’s death. Indolent lymphomas, such as FL, as in these cases, have the potential to develop BMN. It is important to detect the development of BMN and administer chemotherapy early to improve patient prognosis, since severe BMN prevents patients from receiving effective treatment.</description><subject>Bone Marrow - pathology</subject><subject>bone marrow necrosis</subject><subject>Case Report</subject><subject>follicular lymphoma</subject><subject>Genes, myc</subject><subject>hematopoiesis</subject><subject>Humans</subject><subject>Lymphoma, Follicular - drug therapy</subject><subject>Lymphoma, Follicular - genetics</subject><subject>Lymphoma, Follicular - pathology</subject><subject>Lymphoma, Non-Hodgkin - pathology</subject><subject>MYC abnormalities</subject><subject>Necrosis - pathology</subject><issn>1346-4280</issn><issn>1880-9952</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEtPAyEURonRWK2u3Bv2ZpQZKGU2JqbxlWjc6MIVuWWgQ8MMDaBN_730YaMbILnnfnw5CF2U5JrWnNzMowvpuqoIYQfopBSCFHU9qg7zmzJesEqQATqNcZ4BPuL0GA0or3hJKT1B-n3psYKoI_YGG--cVV8OAnarbtH6DvDSpha_fk7wTPcaw7T3oQNnk80rqYWEF0FH3SfdbNGpz1gHIfgl7rUKPtp4ho4MuKjPd_cQfTzcv0-eipe3x-fJ3UuhmBinAoipx2NKp1XDGm1IA0wprkndsJKNFGmY4LSqQRiihGKNgLIUMOIMjBGKAB2i223u4mva6UblWgGcXASbC62kByv_T3rbypn_lrWoxTgbGaKrbcC6dwza7HdLIte25ca23NjO9OXf7_bsr94M3G2BeUww03sAQrLK6V0YryRbH5vQ_Uy1EKTu6Q9rPJdH</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Miyazawa, Yuri</creator><creator>Takei, Hisashi</creator><creator>Kobayashi, Nobuhiko</creator><creator>Akashi, Naoki</creator><creator>Sairenji, Yukiko</creator><creator>Sugisaki, Manato</creator><creator>Naito, Chiaki</creator><creator>Ishikawa, Tetsuya</creator><creator>Shimizu, Hiroaki</creator><creator>Ishizaki, Takuma</creator><creator>Yokohama, Akihiko</creator><creator>Tsukamoto, Norifumi</creator><creator>Yoshida, Yuka</creator><creator>Matsumura, Nozomi</creator><creator>Takayama, Yoshiyasu</creator><creator>Handa, Hiroshi</creator><general>The Japanese Society for Lymphoreticular Tissue Research</general><general>JSLRT</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20220101</creationdate><title>Two cases of follicular lymphoma with MYC gene abnormalities that presented with bone marrow necrosis</title><author>Miyazawa, Yuri ; Takei, Hisashi ; Kobayashi, Nobuhiko ; Akashi, Naoki ; Sairenji, Yukiko ; Sugisaki, Manato ; Naito, Chiaki ; Ishikawa, Tetsuya ; Shimizu, Hiroaki ; Ishizaki, Takuma ; Yokohama, Akihiko ; Tsukamoto, Norifumi ; Yoshida, Yuka ; Matsumura, Nozomi ; Takayama, Yoshiyasu ; Handa, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-a0f97733b2d4def0da4cc6e09d4145c0d486329a8f0c8c4d8a118a564aff8c0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bone Marrow - pathology</topic><topic>bone marrow necrosis</topic><topic>Case Report</topic><topic>follicular lymphoma</topic><topic>Genes, myc</topic><topic>hematopoiesis</topic><topic>Humans</topic><topic>Lymphoma, Follicular - drug therapy</topic><topic>Lymphoma, Follicular - genetics</topic><topic>Lymphoma, Follicular - pathology</topic><topic>Lymphoma, Non-Hodgkin - pathology</topic><topic>MYC abnormalities</topic><topic>Necrosis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyazawa, Yuri</creatorcontrib><creatorcontrib>Takei, Hisashi</creatorcontrib><creatorcontrib>Kobayashi, Nobuhiko</creatorcontrib><creatorcontrib>Akashi, Naoki</creatorcontrib><creatorcontrib>Sairenji, Yukiko</creatorcontrib><creatorcontrib>Sugisaki, Manato</creatorcontrib><creatorcontrib>Naito, Chiaki</creatorcontrib><creatorcontrib>Ishikawa, Tetsuya</creatorcontrib><creatorcontrib>Shimizu, Hiroaki</creatorcontrib><creatorcontrib>Ishizaki, Takuma</creatorcontrib><creatorcontrib>Yokohama, Akihiko</creatorcontrib><creatorcontrib>Tsukamoto, Norifumi</creatorcontrib><creatorcontrib>Yoshida, Yuka</creatorcontrib><creatorcontrib>Matsumura, Nozomi</creatorcontrib><creatorcontrib>Takayama, Yoshiyasu</creatorcontrib><creatorcontrib>Handa, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical and Experimental Hematopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyazawa, Yuri</au><au>Takei, Hisashi</au><au>Kobayashi, Nobuhiko</au><au>Akashi, Naoki</au><au>Sairenji, Yukiko</au><au>Sugisaki, Manato</au><au>Naito, Chiaki</au><au>Ishikawa, Tetsuya</au><au>Shimizu, Hiroaki</au><au>Ishizaki, Takuma</au><au>Yokohama, Akihiko</au><au>Tsukamoto, Norifumi</au><au>Yoshida, Yuka</au><au>Matsumura, Nozomi</au><au>Takayama, Yoshiyasu</au><au>Handa, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two cases of follicular lymphoma with MYC gene abnormalities that presented with bone marrow necrosis</atitle><jtitle>Journal of Clinical and Experimental Hematopathology</jtitle><addtitle>J Clin Exp Hematopathol</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>62</volume><issue>4</issue><spage>208</spage><epage>216</epage><pages>208-216</pages><artnum>22004</artnum><issn>1346-4280</issn><eissn>1880-9952</eissn><abstract>Bone marrow necrosis (BMN) occurs most frequently in hematological malignancies and sometimes in non-hematological disorders. Lymphoid diseases causing necrosis are regarded as high-grade disease. B-lymphoblastic leukemia/lymphoma is the most common malignant cause of BMN. Here, we present two patients with follicular lymphoma (FL) and MYC gene abnormalities who developed BMN. In one case of BMN, the necrosis disappeared in response to chemotherapy, and the patient survived with complete remission. In the other case, BMN remained even after chemotherapy, and effective chemotherapy could not be administered due to suppressed hematopoiesis, which led to the lymphoma worsening and the patient’s death. Indolent lymphomas, such as FL, as in these cases, have the potential to develop BMN. 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| subjects | Bone Marrow - pathology bone marrow necrosis Case Report follicular lymphoma Genes, myc hematopoiesis Humans Lymphoma, Follicular - drug therapy Lymphoma, Follicular - genetics Lymphoma, Follicular - pathology Lymphoma, Non-Hodgkin - pathology MYC abnormalities Necrosis - pathology |
| title | Two cases of follicular lymphoma with MYC gene abnormalities that presented with bone marrow necrosis |
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