Diagnostics in Waldenström’s macroglobulinemia: a consensus statement of the European Consortium for Waldenström’s Macroglobulinemia
The diagnosis of Waldenström’s macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease presentation. Furthermore, in recent years, WM has witnessed remarkable progress on the diagnostic front, as well as a deeper understanding of...
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| Veröffentlicht in: | Leukemia 2023-02, Vol.37 (2), p.388-395 |
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| creator | Dogliotti, Irene Jiménez, Cristina Varettoni, Marzia Talaulikar, Dipti Bagratuni, Tina Ferrante, Martina Pérez, José Drandi, Daniela Puig, Noemí Gilestro, Milena García-Álvarez, María Owen, Roger Jurczak, Wojciech Tedeschi, Alessandra Leblond, Veronique Kastritis, Efstathios Kersten, Marie José D’Sa, Shirley Kaščák, Michal Willenbacher, Wolfgang Roccaro, Aldo M. Poulain, Stephanie Morel, Pierre Kyriakou, Charalampia Fend, Falko Vos, Josephine M. I. Dimopoulos, Meletios A. Buske, Christian Ferrero, Simone García-Sanz, Ramón |
| description | The diagnosis of Waldenström’s macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease presentation. Furthermore, in recent years, WM has witnessed remarkable progress on the diagnostic front, as well as a deeper understanding of the disease biology, which has affected clinical practice. This, together with the increasing variety of tools and techniques available, makes it necessary to have a practical guidance for clinicians to perform the initial evaluation of patients with WM. In this paper, we present the consensus recommendations and laboratory requirements for the diagnosis of WM developed by the European Consortium of Waldenström’s Macroglobulinemia (ECWM), for both clinical practice as well as the research/academical setting. We provide the procedures for multiparametric flow cytometry, fluorescence in situ hybridization and molecular tests, and with this offer guidance for a standardized diagnostic work-up and methodological workflow of patients with IgM monoclonal gammopathy of uncertain significance, asymptomatic and symptomatic WM. |
| doi_str_mv | 10.1038/s41375-022-01762-3 |
| format | Article |
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Furthermore, in recent years, WM has witnessed remarkable progress on the diagnostic front, as well as a deeper understanding of the disease biology, which has affected clinical practice. This, together with the increasing variety of tools and techniques available, makes it necessary to have a practical guidance for clinicians to perform the initial evaluation of patients with WM. In this paper, we present the consensus recommendations and laboratory requirements for the diagnosis of WM developed by the European Consortium of Waldenström’s Macroglobulinemia (ECWM), for both clinical practice as well as the research/academical setting. 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I. ; Dimopoulos, Meletios A. ; Buske, Christian ; Ferrero, Simone ; García-Sanz, Ramón</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c623t-81615ff217c40572e8a8a1420c0902e7b9c98e98af088d67bd3fe323d52efd4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>13/31</topic><topic>13/51</topic><topic>14/32</topic><topic>38/23</topic><topic>38/77</topic><topic>45/22</topic><topic>692/699/1541/1990/291/1621/1915</topic><topic>692/700/139/1512</topic><topic>Cancer Research</topic><topic>Clinical medicine</topic><topic>Consortia</topic><topic>Critical Care Medicine</topic><topic>Diagnosis</topic><topic>Flow cytometry</topic><topic>Fluorescence</topic><topic>Fluorescence in situ hybridization</topic><topic>Hematology</topic><topic>Humans</topic><topic>Immunoglobulin M</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Intensive</topic><topic>Internal Medicine</topic><topic>Life Sciences</topic><topic>Lymphoma</topic><topic>Macroglobulinemia</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Monoclonal gammopathy</topic><topic>Oncology</topic><topic>Waldenstrom Macroglobulinemia - diagnosis</topic><topic>Workflow</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dogliotti, Irene</creatorcontrib><creatorcontrib>Jiménez, Cristina</creatorcontrib><creatorcontrib>Varettoni, Marzia</creatorcontrib><creatorcontrib>Talaulikar, Dipti</creatorcontrib><creatorcontrib>Bagratuni, Tina</creatorcontrib><creatorcontrib>Ferrante, Martina</creatorcontrib><creatorcontrib>Pérez, José</creatorcontrib><creatorcontrib>Drandi, Daniela</creatorcontrib><creatorcontrib>Puig, Noemí</creatorcontrib><creatorcontrib>Gilestro, Milena</creatorcontrib><creatorcontrib>García-Álvarez, María</creatorcontrib><creatorcontrib>Owen, Roger</creatorcontrib><creatorcontrib>Jurczak, Wojciech</creatorcontrib><creatorcontrib>Tedeschi, Alessandra</creatorcontrib><creatorcontrib>Leblond, Veronique</creatorcontrib><creatorcontrib>Kastritis, Efstathios</creatorcontrib><creatorcontrib>Kersten, Marie José</creatorcontrib><creatorcontrib>D’Sa, Shirley</creatorcontrib><creatorcontrib>Kaščák, Michal</creatorcontrib><creatorcontrib>Willenbacher, Wolfgang</creatorcontrib><creatorcontrib>Roccaro, Aldo M.</creatorcontrib><creatorcontrib>Poulain, Stephanie</creatorcontrib><creatorcontrib>Morel, Pierre</creatorcontrib><creatorcontrib>Kyriakou, Charalampia</creatorcontrib><creatorcontrib>Fend, Falko</creatorcontrib><creatorcontrib>Vos, Josephine M. I.</creatorcontrib><creatorcontrib>Dimopoulos, Meletios A.</creatorcontrib><creatorcontrib>Buske, Christian</creatorcontrib><creatorcontrib>Ferrero, Simone</creatorcontrib><creatorcontrib>García-Sanz, Ramón</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Leukemia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dogliotti, Irene</au><au>Jiménez, Cristina</au><au>Varettoni, Marzia</au><au>Talaulikar, Dipti</au><au>Bagratuni, Tina</au><au>Ferrante, Martina</au><au>Pérez, José</au><au>Drandi, Daniela</au><au>Puig, Noemí</au><au>Gilestro, Milena</au><au>García-Álvarez, María</au><au>Owen, Roger</au><au>Jurczak, Wojciech</au><au>Tedeschi, Alessandra</au><au>Leblond, Veronique</au><au>Kastritis, Efstathios</au><au>Kersten, Marie José</au><au>D’Sa, Shirley</au><au>Kaščák, Michal</au><au>Willenbacher, Wolfgang</au><au>Roccaro, Aldo M.</au><au>Poulain, Stephanie</au><au>Morel, Pierre</au><au>Kyriakou, Charalampia</au><au>Fend, Falko</au><au>Vos, Josephine M. I.</au><au>Dimopoulos, Meletios A.</au><au>Buske, Christian</au><au>Ferrero, Simone</au><au>García-Sanz, Ramón</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostics in Waldenström’s macroglobulinemia: a consensus statement of the European Consortium for Waldenström’s Macroglobulinemia</atitle><jtitle>Leukemia</jtitle><stitle>Leukemia</stitle><addtitle>Leukemia</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>37</volume><issue>2</issue><spage>388</spage><epage>395</epage><pages>388-395</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><abstract>The diagnosis of Waldenström’s macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease presentation. Furthermore, in recent years, WM has witnessed remarkable progress on the diagnostic front, as well as a deeper understanding of the disease biology, which has affected clinical practice. This, together with the increasing variety of tools and techniques available, makes it necessary to have a practical guidance for clinicians to perform the initial evaluation of patients with WM. In this paper, we present the consensus recommendations and laboratory requirements for the diagnosis of WM developed by the European Consortium of Waldenström’s Macroglobulinemia (ECWM), for both clinical practice as well as the research/academical setting. We provide the procedures for multiparametric flow cytometry, fluorescence in situ hybridization and molecular tests, and with this offer guidance for a standardized diagnostic work-up and methodological workflow of patients with IgM monoclonal gammopathy of uncertain significance, asymptomatic and symptomatic WM.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>36435884</pmid><doi>10.1038/s41375-022-01762-3</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8904-3802</orcidid><orcidid>https://orcid.org/0000-0002-5496-293X</orcidid><orcidid>https://orcid.org/0000-0002-0782-3144</orcidid><orcidid>https://orcid.org/0000-0001-8191-5832</orcidid><orcidid>https://orcid.org/0000-0002-9782-9012</orcidid><orcidid>https://orcid.org/0000-0001-6766-8345</orcidid><orcidid>https://orcid.org/0000-0003-1879-8084</orcidid><orcidid>https://orcid.org/0000-0001-8990-3254</orcidid><orcidid>https://orcid.org/0000-0002-9711-1502</orcidid><orcidid>https://orcid.org/0000-0001-7535-3861</orcidid><orcidid>https://orcid.org/0000-0003-0840-3499</orcidid><orcidid>https://orcid.org/0000-0002-5543-5154</orcidid><orcidid>https://orcid.org/0000-0002-1872-5128</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0887-6924 |
| ispartof | Leukemia, 2023-02, Vol.37 (2), p.388-395 |
| issn | 0887-6924 1476-5551 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9898035 |
| source | MEDLINE; Springer Journals |
| subjects | 13/31 13/51 14/32 38/23 38/77 45/22 692/699/1541/1990/291/1621/1915 692/700/139/1512 Cancer Research Clinical medicine Consortia Critical Care Medicine Diagnosis Flow cytometry Fluorescence Fluorescence in situ hybridization Hematology Humans Immunoglobulin M In Situ Hybridization, Fluorescence Intensive Internal Medicine Life Sciences Lymphoma Macroglobulinemia Medicine Medicine & Public Health Monoclonal gammopathy Oncology Waldenstrom Macroglobulinemia - diagnosis Workflow |
| title | Diagnostics in Waldenström’s macroglobulinemia: a consensus statement of the European Consortium for Waldenström’s Macroglobulinemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T20%3A01%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diagnostics%20in%20Waldenstr%C3%B6m%E2%80%99s%20macroglobulinemia:%20a%20consensus%20statement%20of%20the%20European%20Consortium%20for%20Waldenstr%C3%B6m%E2%80%99s%20Macroglobulinemia&rft.jtitle=Leukemia&rft.au=Dogliotti,%20Irene&rft.date=2023-02-01&rft.volume=37&rft.issue=2&rft.spage=388&rft.epage=395&rft.pages=388-395&rft.issn=0887-6924&rft.eissn=1476-5551&rft_id=info:doi/10.1038/s41375-022-01762-3&rft_dat=%3Cproquest_pubme%3E2740504904%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2772195001&rft_id=info:pmid/36435884&rfr_iscdi=true |