Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function

The glycocalyx component and sialomucin podocalyxin (PODXL) is required for normal tissue development by promoting apical membranes to form between cells, triggering lumen formation. Elevated PODXL expression is also associated with metastasis and poor clinical outcome in multiple tumor types. How P...

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Veröffentlicht in:	Science advances 2023-02, Vol.9 (5), p.eabq1858-eabq1858
Hauptverfasser:	Román-Fernández, Alvaro, Mansour, Mohammed A, Kugeratski, Fernanda G, Anand, Jayanthi, Sandilands, Emma, Galbraith, Laura, Rakovic, Kai, Freckmann, Eva C, Cumming, Erin M, Park, Ji, Nikolatou, Konstantina, Lilla, Sergio, Shaw, Robin, Strachan, David, Mason, Susan, Patel, Rachana, McGarry, Lynn, Katoch, Archana, Campbell, Kirsteen J, Nixon, Colin, Miller, Crispin J, Leung, Hing Y, Le Quesne, John, Norman, James C, Zanivan, Sara, Blyth, Karen, Bryant, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedicine and Life Sciences Cancer Cell Biology Glycocalyx - metabolism Heterografts Humans Male SciAdv r-articles Sialoglycoproteins - metabolism Transplantation, Heterologous
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