Evaluation of neurotrophic factor secreting mesenchymal stem cells in progressive multiple sclerosis

Background: Autologous mesenchymal stem cell neurotrophic factor–secreting cells (NurOwn®) have the potential to modify underlying disease mechanisms in progressive multiple sclerosis (PMS). Objective: This open-label phase II study was conducted to evaluate safety/efficacy of three intrathecal cell...

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Veröffentlicht in:	Multiple sclerosis 2023-01, Vol.29 (1), p.92-106
Hauptverfasser:	Cohen, Jeffrey A, Lublin, Fred D, Lock, Christoper, Pelletier, Daniel, Chitnis, Tanuja, Mehra, Munish, Gothelf, Yael, Aricha, Revital, Lindborg, Stacy, Lebovits, Chaim, Levy, Yossef, Motamed Khorasani, Afsaneh, Kern, Ralph
Format:	Artikel
Sprache:	eng
Schlagworte:	Acuity Arachnoiditis Autografts Biomarkers Cerebrospinal fluid Humans Inflammation Magnetic resonance imaging Mesenchymal Stem Cells Multiple sclerosis Multiple Sclerosis - diagnosis Multiple Sclerosis, Chronic Progressive - therapy Nerve Growth Factors Neuroprotection Neurotrophic factors Original Research Papers Safety Stem cells
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