CD8+ lymphocytes do not impact SIV reservoir establishment under ART

Persistence of the human immunodeficiency virus type-1 (HIV-1) latent reservoir in infected individuals remains a problem despite fully suppressive antiretroviral therapy (ART). While reservoir formation begins during acute infection, the mechanisms responsible for its establishment remain unclear....

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Veröffentlicht in:	Nature microbiology 2023-02, Vol.8 (2), p.299-308
Hauptverfasser:	Statzu, Maura, Jin, Wang, Fray, Emily J., Wong, Andrew Kam Ho, Kumar, Mithra R., Ferrer, Elizabeth, Docken, Steffen S., Pinkevych, Mykola, McBrien, Julia B., Fennessey, Christine M., Keele, Brandon F., Liang, Shan, Harper, Justin L., Mutascio, Simona, Franchitti, Lavinia, Wang, Hong, Cicetti, Davide, Bosinger, Steven E., Carnathan, Diane G., Vanderford, Thomas H., Margolis, David M., Garcia-Martinez, J. Victor, Chahroudi, Ann, Paiardini, Mirko, Siliciano, Janet, Davenport, Miles P., Kulpa, Deanna A., Siliciano, Robert S., Silvestri, Guido
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 38/77 631/250/255/1901 631/326/596/2564 Animals Anti-Retroviral Agents - therapeutic use Antiretroviral therapy Biomedical and Life Sciences CD4 antigen CD8 antigen CD8-Positive T-Lymphocytes Cytotoxicity Drug therapy HIV HIV Infections - drug therapy Human immunodeficiency virus Humans Immune system Infections Infectious Diseases Life Sciences Life span Lymph nodes Lymphocytes Lymphocytes T Macaca mulatta Medical Microbiology Microbiology Parasitology Primates Simian Acquired Immunodeficiency Syndrome - drug therapy Simian Immunodeficiency Virus - genetics Viremia Virology Viruses
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