A cis-regulatory lexicon of DNA motif combinations mediating cell-type-specific gene regulation

Gene expression is controlled by transcription factors (TFs) that bind cognate DNA motif sequences in cis-regulatory elements (CREs). The combinations of DNA motifs acting within homeostasis and disease, however, are unclear. Gene expression, chromatin accessibility, TF footprinting, and H3K27ac-dep...

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Veröffentlicht in:	Cell genomics 2022-11, Vol.2 (11), p.100191, Article 100191
Hauptverfasser:	Donohue, Laura K.H., Guo, Margaret G., Zhao, Yang, Jung, Namyoung, Bussat, Rose T., Kim, Daniel S., Neela, Poornima H., Kellman, Laura N., Garcia, Omar S., Meyers, Robin M., Altman, Russ B., Khavari, Paul A.
Format:	Artikel
Sprache:	eng
Schlagworte:	cis-regulatory logic gene regulation massively parallel reporter assay multi-omics random-forest model
Online-Zugang:	Volltext
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