Limited Proteolysis-Mass Spectrometry Reveals Aging-Associated Changes in Cerebrospinal Fluid Protein Abundances and Structures

Cerebrospinal fluid (CSF) proteins and their structures have been implicated repeatedly in aging and neurodegenerative diseases. Limited proteolysis-mass spectrometry (LiP-MS) is a method that enables proteome-wide screening for changes in both protein abundance and structure. To screen for novel ag...

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Veröffentlicht in:	Nature aging 2022-05, Vol.2 (5), p.379-388
Hauptverfasser:	Shuken, Steven R, Rutledge, Jarod, Iram, Tal, Losada, Patricia Moran, Wilson, Edward N, Andreasson, Katrin I, Leib, Ryan D, Wyss-Coray, Tony
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Cerebrospinal fluid Mass spectrometry Neurodegeneration Proteins Scientific imaging
Online-Zugang:	Volltext
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