Identification of Hetero-aggregates in Antibody Co-formulations by Multi-dimensional Liquid Chromatography Coupled to Mass Spectrometry

Antibody combination therapies have become viable therapeutic treatment options for certain severe diseases such as cancer. The co-formulation production approach is intrinsically associated with more complex drug product variant profiles and creates more challenges for analytical control of drug pr...

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Veröffentlicht in:	Analytical chemistry (Washington) 2023-01, Vol.95 (4), p.2203-2212
Hauptverfasser:	Kuhne, Felix, Heinrich, Katrin, Winter, Martin, Fichtl, Jürgen, Hoffmann, Gabriel, Zähringer, Franziska, Spitzauer, Katharina, Meier, Monika, Khan, Tarik A., Bonnington, Lea, Wagner, Katharina, Stracke, Jan Olaf, Reusch, Dietmar, Wegele, Harald, Mormann, Michael, Bulau, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Analytical chemistry Antibodies Antibodies, Monoclonal - chemistry Chemistry Chromatography Chromatography, Liquid Liquid chromatography Mass spectrometry Mass spectroscopy Monoclonal antibodies Physicochemical properties Quality management Scientific imaging Spectroscopy Storage conditions Tandem Mass Spectrometry Trastuzumab Trastuzumab - chemistry
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