Current Treatment Options for the Failing Fontan Circulation

Current Treatment Options for the Failing Fontan Circulation

The Fontan operation was introduced in 1968. For congenital malformations, where biventricular repair is unsuitable, the Fontan procedure has provided a long-term palliation strategy with improved outcomes compared to the initially developed procedures. Despite these improvements, several complicati...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Current cardiology reviews 2022-07, Vol.18 (4), p.40-e060122200067
Hauptverfasser: Driesen, Bart W, Voskuil, Michiel, Grotenhuis, Heynric B
Format: Artikel
Sprache:eng
Schlagworte:
Bronchitis
Cardiology
Complications
Congenital defects
Embolism
Heart surgery
Life span
Palliation
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page e060122200067
container_issue 4
container_start_page 40
container_title Current cardiology reviews
container_volume 18
creator Driesen, Bart W
Voskuil, Michiel
Grotenhuis, Heynric B
description The Fontan operation was introduced in 1968. For congenital malformations, where biventricular repair is unsuitable, the Fontan procedure has provided a long-term palliation strategy with improved outcomes compared to the initially developed procedures. Despite these improvements, several complications merely due to a failing Fontan circulation, including myocardial dysfunction, arrhythmias, increased pulmonary vascular resistance, protein-losing enteropathy, hepatic dysfunction, plastic bronchitis, and thrombo-embolism, may occur, thereby limiting the life-expectancy in this patient cohort. This review provides an overview of the most common complications of Fontan circulation and the currently available treatment options.
doi_str_mv 10.2174/1573403X18666220106114518
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9893132</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2696312820</sourcerecordid><originalsourceid>FETCH-LOGICAL-b524t-ec38b1ccc8349c0a2188735444ec25b963dc7af80064a6fb82c0638f3bbb96c53</originalsourceid><addsrcrecordid>eNp1kk2L1EAQhoMo7rr6FyTixUu0v9MBEWRwVFjYywreik5vZabXpDt2d3bw7B-3w6yDCp6qqPepL6qq6gUlrxltxRsqWy4I_0q1UooxQomiVEiqH1TnVLeyUVK2D4tfuGYFz6onKd0SIpnq6OPqjIuuE5zT8-rtZokRfa6vI5o8rd7VnF3wqR5CrPMe661xo_O7eht8Nr7euGiX0azM0-rRYMaEz-7tRfVl--F686m5vPr4efP-suklE7lBy3VPrbW69LXEMKp1y6UQAi2Tfaf4jW3NoAlRwqih18wSxfXA-76IVvKL6t2x7rz0E97YMmU0I8zRTSb-gGAc_K14t4dduINOd5xyVgq8ui8Qw_cFU4bJJYvjaDyGJQFTVDMuWr32evkPehuW6Mt6hSqjUqYZKVR3pGwMKUUcTsNQAuuN4L83KrnP_9zmlPn7KAX4eQT6ss7eTMk69BZP4D7nGQ6HA-AS8ZtJOKLNYMMEYUa_xLH4PpdcmPcz7NBHBBOzsyOCS8nD-iOw_gjchXGZsARWYUEQkGazK5bwX5nNv4w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2696312820</pqid></control><display><type>article</type><title>Current Treatment Options for the Failing Fontan Circulation</title><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Driesen, Bart W ; Voskuil, Michiel ; Grotenhuis, Heynric B</creator><creatorcontrib>Driesen, Bart W ; Voskuil, Michiel ; Grotenhuis, Heynric B</creatorcontrib><description>The Fontan operation was introduced in 1968. For congenital malformations, where biventricular repair is unsuitable, the Fontan procedure has provided a long-term palliation strategy with improved outcomes compared to the initially developed procedures. Despite these improvements, several complications merely due to a failing Fontan circulation, including myocardial dysfunction, arrhythmias, increased pulmonary vascular resistance, protein-losing enteropathy, hepatic dysfunction, plastic bronchitis, and thrombo-embolism, may occur, thereby limiting the life-expectancy in this patient cohort. This review provides an overview of the most common complications of Fontan circulation and the currently available treatment options.</description><identifier>ISSN: 1573-403X</identifier><identifier>EISSN: 1875-6557</identifier><identifier>DOI: 10.2174/1573403X18666220106114518</identifier><identifier>PMID: 34994331</identifier><language>eng</language><publisher>United Arab Emirates: Bentham Science Publishers Ltd</publisher><subject>Bronchitis ; Cardiology ; Complications ; Congenital defects ; Embolism ; Heart surgery ; Life span ; Palliation</subject><ispartof>Current cardiology reviews, 2022-07, Vol.18 (4), p.40-e060122200067</ispartof><rights>Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.</rights><rights>Copyright Benham Science Publishers Jul 2022</rights><rights>2022 Bentham Science Publishers 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b524t-ec38b1ccc8349c0a2188735444ec25b963dc7af80064a6fb82c0638f3bbb96c53</citedby><cites>FETCH-LOGICAL-b524t-ec38b1ccc8349c0a2188735444ec25b963dc7af80064a6fb82c0638f3bbb96c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893132/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893132/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34994331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Driesen, Bart W</creatorcontrib><creatorcontrib>Voskuil, Michiel</creatorcontrib><creatorcontrib>Grotenhuis, Heynric B</creatorcontrib><title>Current Treatment Options for the Failing Fontan Circulation</title><title>Current cardiology reviews</title><addtitle>CCR</addtitle><description>The Fontan operation was introduced in 1968. For congenital malformations, where biventricular repair is unsuitable, the Fontan procedure has provided a long-term palliation strategy with improved outcomes compared to the initially developed procedures. Despite these improvements, several complications merely due to a failing Fontan circulation, including myocardial dysfunction, arrhythmias, increased pulmonary vascular resistance, protein-losing enteropathy, hepatic dysfunction, plastic bronchitis, and thrombo-embolism, may occur, thereby limiting the life-expectancy in this patient cohort. This review provides an overview of the most common complications of Fontan circulation and the currently available treatment options.</description><subject>Bronchitis</subject><subject>Cardiology</subject><subject>Complications</subject><subject>Congenital defects</subject><subject>Embolism</subject><subject>Heart surgery</subject><subject>Life span</subject><subject>Palliation</subject><issn>1573-403X</issn><issn>1875-6557</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kk2L1EAQhoMo7rr6FyTixUu0v9MBEWRwVFjYywreik5vZabXpDt2d3bw7B-3w6yDCp6qqPepL6qq6gUlrxltxRsqWy4I_0q1UooxQomiVEiqH1TnVLeyUVK2D4tfuGYFz6onKd0SIpnq6OPqjIuuE5zT8-rtZokRfa6vI5o8rd7VnF3wqR5CrPMe661xo_O7eht8Nr7euGiX0azM0-rRYMaEz-7tRfVl--F686m5vPr4efP-suklE7lBy3VPrbW69LXEMKp1y6UQAi2Tfaf4jW3NoAlRwqih18wSxfXA-76IVvKL6t2x7rz0E97YMmU0I8zRTSb-gGAc_K14t4dduINOd5xyVgq8ui8Qw_cFU4bJJYvjaDyGJQFTVDMuWr32evkPehuW6Mt6hSqjUqYZKVR3pGwMKUUcTsNQAuuN4L83KrnP_9zmlPn7KAX4eQT6ss7eTMk69BZP4D7nGQ6HA-AS8ZtJOKLNYMMEYUa_xLH4PpdcmPcz7NBHBBOzsyOCS8nD-iOw_gjchXGZsARWYUEQkGazK5bwX5nNv4w</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Driesen, Bart W</creator><creator>Voskuil, Michiel</creator><creator>Grotenhuis, Heynric B</creator><general>Bentham Science Publishers Ltd</general><general>Benham Science Publishers</general><general>Bentham Science Publishers</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220701</creationdate><title>Current Treatment Options for the Failing Fontan Circulation</title><author>Driesen, Bart W ; Voskuil, Michiel ; Grotenhuis, Heynric B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b524t-ec38b1ccc8349c0a2188735444ec25b963dc7af80064a6fb82c0638f3bbb96c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bronchitis</topic><topic>Cardiology</topic><topic>Complications</topic><topic>Congenital defects</topic><topic>Embolism</topic><topic>Heart surgery</topic><topic>Life span</topic><topic>Palliation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Driesen, Bart W</creatorcontrib><creatorcontrib>Voskuil, Michiel</creatorcontrib><creatorcontrib>Grotenhuis, Heynric B</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current cardiology reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Driesen, Bart W</au><au>Voskuil, Michiel</au><au>Grotenhuis, Heynric B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Current Treatment Options for the Failing Fontan Circulation</atitle><jtitle>Current cardiology reviews</jtitle><addtitle>CCR</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>18</volume><issue>4</issue><spage>40</spage><epage>e060122200067</epage><pages>40-e060122200067</pages><issn>1573-403X</issn><eissn>1875-6557</eissn><abstract>The Fontan operation was introduced in 1968. For congenital malformations, where biventricular repair is unsuitable, the Fontan procedure has provided a long-term palliation strategy with improved outcomes compared to the initially developed procedures. Despite these improvements, several complications merely due to a failing Fontan circulation, including myocardial dysfunction, arrhythmias, increased pulmonary vascular resistance, protein-losing enteropathy, hepatic dysfunction, plastic bronchitis, and thrombo-embolism, may occur, thereby limiting the life-expectancy in this patient cohort. This review provides an overview of the most common complications of Fontan circulation and the currently available treatment options.</abstract><cop>United Arab Emirates</cop><pub>Bentham Science Publishers Ltd</pub><pmid>34994331</pmid><doi>10.2174/1573403X18666220106114518</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1573-403X
ispartof Current cardiology reviews, 2022-07, Vol.18 (4), p.40-e060122200067
issn 1573-403X
1875-6557
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9893132
source EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Bronchitis
Cardiology
Complications
Congenital defects
Embolism
Heart surgery
Life span
Palliation
title Current Treatment Options for the Failing Fontan Circulation
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T09%3A36%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Current%20Treatment%20Options%20for%20the%20Failing%20Fontan%20Circulation&rft.jtitle=Current%20cardiology%20reviews&rft.au=Driesen,%20Bart%20W&rft.date=2022-07-01&rft.volume=18&rft.issue=4&rft.spage=40&rft.epage=e060122200067&rft.pages=40-e060122200067&rft.issn=1573-403X&rft.eissn=1875-6557&rft_id=info:doi/10.2174/1573403X18666220106114518&rft_dat=%3Cproquest_pubme%3E2696312820%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2696312820&rft_id=info:pmid/34994331&rfr_iscdi=true