Systemic lupus erythematosus myocarditis after COVID-19 vaccination
Cases of acute myocarditis have been after administration of the BNT162b2 and Ad26.COV2.S vaccine. Describe another possible mechanism of myocarditis after COVID-19 vaccination. We describe the clinical case of a 72-year-old female with pleuritic chest pain one week after the third of the BNT162b2 m...
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| Veröffentlicht in: | Reumatología clinica (Barcelona) 2023-02, Vol.19 (2), p.114-116 |
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| creator | Sogbe, Miguel Blanco-Di Matteo, Andrés Di Frisco, I. Madeleine Bastidas, Juan Fernando Salterain, Nahikari Gavira, Juan José |
| description | Cases of acute myocarditis have been after administration of the BNT162b2 and Ad26.COV2.S vaccine.
Describe another possible mechanism of myocarditis after COVID-19 vaccination.
We describe the clinical case of a 72-year-old female with pleuritic chest pain one week after the third of the BNT162b2 mRNA vaccine. Serological tests for cardiotropic pathogens were negative, and autoimmunity screening was positive with anti-nuclear antibody (ANA) in 1:160 dilution, Anti-double-stranded DNA (anti-dsDNA), and anti-histone antibodies. 18F-fluoro-deoxy-glucose (FDG) positron emission tomography/computed tomography (PET/CT) showed a focal myocardial and pericardial inflammatory process in the cardiac apex.
Systemic lupus erythematosus (SLE) diagnosis was made with myocardial affection. As far as we know, this is the first report of a case of lupus myocarditis after the COVID-19 vaccine.
Given the pathogenic rationales, the association between SLE and myocarditis should be considered.
Se han presentado casos de miocarditis aguda tras la administración de las vacunas BNT162b2 y Ad26.COV2.S.
Describir otro posible mecanismo de miocarditis posterior a la vacunación contra el COVID-19.
Describimos el caso clínico de una mujer de 72 años con dolor torácico pleurítico una semana después de la tercera vacuna de ARNm BNT162b2. Las pruebas serológicas para patógenos cardiotrópos fueron negativas y el cribado de autoinmunidad fue positivo con anticuerpos antinucleares (ANA) en dilución 1:160, anticuerpos anti-ADN de doble cadena (anti-dsADN) y antihistonas. La tomografía por emisión de positrones/tomografía computarizada (PET/TC) con 18F-fluorodesoxiglucosa (FDG) mostró un proceso inflamatorio miocárdico y pericárdico focal en el ápex cardíaco.
Se realizó el diagnóstico de lupus eritematoso sistémico (LES) con afectación miocárdica. Hasta donde sabemos, este es el primer reporte de un caso de miocarditis lúpica después de la vacuna contra el COVID-19.
Dadas las justificaciones patogénicas, se debe considerar la asociación entre lupus eritematoso sistémico (LES) y miocarditis. |
| doi_str_mv | 10.1016/j.reumae.2022.06.006 |
| format | Article |
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Describe another possible mechanism of myocarditis after COVID-19 vaccination.
We describe the clinical case of a 72-year-old female with pleuritic chest pain one week after the third of the BNT162b2 mRNA vaccine. Serological tests for cardiotropic pathogens were negative, and autoimmunity screening was positive with anti-nuclear antibody (ANA) in 1:160 dilution, Anti-double-stranded DNA (anti-dsDNA), and anti-histone antibodies. 18F-fluoro-deoxy-glucose (FDG) positron emission tomography/computed tomography (PET/CT) showed a focal myocardial and pericardial inflammatory process in the cardiac apex.
Systemic lupus erythematosus (SLE) diagnosis was made with myocardial affection. As far as we know, this is the first report of a case of lupus myocarditis after the COVID-19 vaccine.
Given the pathogenic rationales, the association between SLE and myocarditis should be considered.
Se han presentado casos de miocarditis aguda tras la administración de las vacunas BNT162b2 y Ad26.COV2.S.
Describir otro posible mecanismo de miocarditis posterior a la vacunación contra el COVID-19.
Describimos el caso clínico de una mujer de 72 años con dolor torácico pleurítico una semana después de la tercera vacuna de ARNm BNT162b2. Las pruebas serológicas para patógenos cardiotrópos fueron negativas y el cribado de autoinmunidad fue positivo con anticuerpos antinucleares (ANA) en dilución 1:160, anticuerpos anti-ADN de doble cadena (anti-dsADN) y antihistonas. La tomografía por emisión de positrones/tomografía computarizada (PET/TC) con 18F-fluorodesoxiglucosa (FDG) mostró un proceso inflamatorio miocárdico y pericárdico focal en el ápex cardíaco.
Se realizó el diagnóstico de lupus eritematoso sistémico (LES) con afectación miocárdica. Hasta donde sabemos, este es el primer reporte de un caso de miocarditis lúpica después de la vacuna contra el COVID-19.
Dadas las justificaciones patogénicas, se debe considerar la asociación entre lupus eritematoso sistémico (LES) y miocarditis.</description><identifier>ISSN: 2173-5743</identifier><identifier>EISSN: 2173-5743</identifier><identifier>DOI: 10.1016/j.reumae.2022.06.006</identifier><identifier>PMID: 36739118</identifier><language>eng</language><publisher>Spain: Elsevier España, S.L.U</publisher><subject>Ad26COVS1 ; Aged ; Antibodies, Antinuclear ; ARN mensajero BNT162B2 ; BNT162 Vaccine ; BNT162B2 messenger RNA ; Case Report ; COVID-19 - prevention & control ; COVID-19 vaccination ; COVID-19 Vaccines - adverse effects ; Female ; Humans ; Lupus eritematoso sistémico ; Lupus Erythematosus, Systemic - diagnosis ; Miocarditis ; Myocarditis ; Myocarditis - diagnosis ; Myocarditis - etiology ; Positron Emission Tomography Computed Tomography ; Systemic lupus erythematosus ; Vaccination ; Vacunación COVID-19</subject><ispartof>Reumatología clinica (Barcelona), 2023-02, Vol.19 (2), p.114-116</ispartof><rights>2022 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología</rights><rights>Copyright © 2022 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.</rights><rights>2022 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved. 2022 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2246-68ac136bdd1ae1e2669ac3e12d0236faddddafd8f94e458e07c4e914b28c713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36739118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sogbe, Miguel</creatorcontrib><creatorcontrib>Blanco-Di Matteo, Andrés</creatorcontrib><creatorcontrib>Di Frisco, I. Madeleine</creatorcontrib><creatorcontrib>Bastidas, Juan Fernando</creatorcontrib><creatorcontrib>Salterain, Nahikari</creatorcontrib><creatorcontrib>Gavira, Juan José</creatorcontrib><title>Systemic lupus erythematosus myocarditis after COVID-19 vaccination</title><title>Reumatología clinica (Barcelona)</title><addtitle>Reumatol Clin (Engl Ed)</addtitle><description>Cases of acute myocarditis have been after administration of the BNT162b2 and Ad26.COV2.S vaccine.
Describe another possible mechanism of myocarditis after COVID-19 vaccination.
We describe the clinical case of a 72-year-old female with pleuritic chest pain one week after the third of the BNT162b2 mRNA vaccine. Serological tests for cardiotropic pathogens were negative, and autoimmunity screening was positive with anti-nuclear antibody (ANA) in 1:160 dilution, Anti-double-stranded DNA (anti-dsDNA), and anti-histone antibodies. 18F-fluoro-deoxy-glucose (FDG) positron emission tomography/computed tomography (PET/CT) showed a focal myocardial and pericardial inflammatory process in the cardiac apex.
Systemic lupus erythematosus (SLE) diagnosis was made with myocardial affection. As far as we know, this is the first report of a case of lupus myocarditis after the COVID-19 vaccine.
Given the pathogenic rationales, the association between SLE and myocarditis should be considered.
Se han presentado casos de miocarditis aguda tras la administración de las vacunas BNT162b2 y Ad26.COV2.S.
Describir otro posible mecanismo de miocarditis posterior a la vacunación contra el COVID-19.
Describimos el caso clínico de una mujer de 72 años con dolor torácico pleurítico una semana después de la tercera vacuna de ARNm BNT162b2. Las pruebas serológicas para patógenos cardiotrópos fueron negativas y el cribado de autoinmunidad fue positivo con anticuerpos antinucleares (ANA) en dilución 1:160, anticuerpos anti-ADN de doble cadena (anti-dsADN) y antihistonas. La tomografía por emisión de positrones/tomografía computarizada (PET/TC) con 18F-fluorodesoxiglucosa (FDG) mostró un proceso inflamatorio miocárdico y pericárdico focal en el ápex cardíaco.
Se realizó el diagnóstico de lupus eritematoso sistémico (LES) con afectación miocárdica. Hasta donde sabemos, este es el primer reporte de un caso de miocarditis lúpica después de la vacuna contra el COVID-19.
Dadas las justificaciones patogénicas, se debe considerar la asociación entre lupus eritematoso sistémico (LES) y miocarditis.</description><subject>Ad26COVS1</subject><subject>Aged</subject><subject>Antibodies, Antinuclear</subject><subject>ARN mensajero BNT162B2</subject><subject>BNT162 Vaccine</subject><subject>BNT162B2 messenger RNA</subject><subject>Case Report</subject><subject>COVID-19 - prevention & control</subject><subject>COVID-19 vaccination</subject><subject>COVID-19 Vaccines - adverse effects</subject><subject>Female</subject><subject>Humans</subject><subject>Lupus eritematoso sistémico</subject><subject>Lupus Erythematosus, Systemic - diagnosis</subject><subject>Miocarditis</subject><subject>Myocarditis</subject><subject>Myocarditis - diagnosis</subject><subject>Myocarditis - etiology</subject><subject>Positron Emission Tomography Computed Tomography</subject><subject>Systemic lupus erythematosus</subject><subject>Vaccination</subject><subject>Vacunación COVID-19</subject><issn>2173-5743</issn><issn>2173-5743</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kNtqwzAMhs3YWEvXNxgjL5DMh9SJbwYjOxUKvejYrXFtZXVpkmI7hbz9UrJ13c10Iwnx_5I-hG4JTggm_H6bOGgrBQnFlCaYJxjzCzSmJGPxLEvZ5Vk9QlPvt7iPnM4Ez67RiPGMCULyMSpWnQ9QWR3t2n3rI3Bd2EClQuP7ruoarZyxwfpIlQFcVCw_5k8xEdFBaW1rFWxT36CrUu08TL_zBK1ent-Lt3ixfJ0Xj4tYU5rymOdKE8bXxhAFBCjnQmkGhBpMGS-V6UOVJi9FCuksB5zpFARJ1zTXGWET9DC47tt1BUZDHZzayb2zlXKdbJSVfye13cjP5iBFLqigWW-QDgbaNd47KE9aguWRqtzKgao8UpWYy55qL7s733sS_TD8PQz63w8WnPTaQq3BWAc6SNPY_zd8Ab6WjMM</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Sogbe, Miguel</creator><creator>Blanco-Di Matteo, Andrés</creator><creator>Di Frisco, I. Madeleine</creator><creator>Bastidas, Juan Fernando</creator><creator>Salterain, Nahikari</creator><creator>Gavira, Juan José</creator><general>Elsevier España, S.L.U</general><general>Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>202302</creationdate><title>Systemic lupus erythematosus myocarditis after COVID-19 vaccination</title><author>Sogbe, Miguel ; Blanco-Di Matteo, Andrés ; Di Frisco, I. Madeleine ; Bastidas, Juan Fernando ; Salterain, Nahikari ; Gavira, Juan José</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2246-68ac136bdd1ae1e2669ac3e12d0236faddddafd8f94e458e07c4e914b28c713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Ad26COVS1</topic><topic>Aged</topic><topic>Antibodies, Antinuclear</topic><topic>ARN mensajero BNT162B2</topic><topic>BNT162 Vaccine</topic><topic>BNT162B2 messenger RNA</topic><topic>Case Report</topic><topic>COVID-19 - prevention & control</topic><topic>COVID-19 vaccination</topic><topic>COVID-19 Vaccines - adverse effects</topic><topic>Female</topic><topic>Humans</topic><topic>Lupus eritematoso sistémico</topic><topic>Lupus Erythematosus, Systemic - diagnosis</topic><topic>Miocarditis</topic><topic>Myocarditis</topic><topic>Myocarditis - diagnosis</topic><topic>Myocarditis - etiology</topic><topic>Positron Emission Tomography Computed Tomography</topic><topic>Systemic lupus erythematosus</topic><topic>Vaccination</topic><topic>Vacunación COVID-19</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sogbe, Miguel</creatorcontrib><creatorcontrib>Blanco-Di Matteo, Andrés</creatorcontrib><creatorcontrib>Di Frisco, I. Madeleine</creatorcontrib><creatorcontrib>Bastidas, Juan Fernando</creatorcontrib><creatorcontrib>Salterain, Nahikari</creatorcontrib><creatorcontrib>Gavira, Juan José</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Reumatología clinica (Barcelona)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sogbe, Miguel</au><au>Blanco-Di Matteo, Andrés</au><au>Di Frisco, I. Madeleine</au><au>Bastidas, Juan Fernando</au><au>Salterain, Nahikari</au><au>Gavira, Juan José</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic lupus erythematosus myocarditis after COVID-19 vaccination</atitle><jtitle>Reumatología clinica (Barcelona)</jtitle><addtitle>Reumatol Clin (Engl Ed)</addtitle><date>2023-02</date><risdate>2023</risdate><volume>19</volume><issue>2</issue><spage>114</spage><epage>116</epage><pages>114-116</pages><issn>2173-5743</issn><eissn>2173-5743</eissn><abstract>Cases of acute myocarditis have been after administration of the BNT162b2 and Ad26.COV2.S vaccine.
Describe another possible mechanism of myocarditis after COVID-19 vaccination.
We describe the clinical case of a 72-year-old female with pleuritic chest pain one week after the third of the BNT162b2 mRNA vaccine. Serological tests for cardiotropic pathogens were negative, and autoimmunity screening was positive with anti-nuclear antibody (ANA) in 1:160 dilution, Anti-double-stranded DNA (anti-dsDNA), and anti-histone antibodies. 18F-fluoro-deoxy-glucose (FDG) positron emission tomography/computed tomography (PET/CT) showed a focal myocardial and pericardial inflammatory process in the cardiac apex.
Systemic lupus erythematosus (SLE) diagnosis was made with myocardial affection. As far as we know, this is the first report of a case of lupus myocarditis after the COVID-19 vaccine.
Given the pathogenic rationales, the association between SLE and myocarditis should be considered.
Se han presentado casos de miocarditis aguda tras la administración de las vacunas BNT162b2 y Ad26.COV2.S.
Describir otro posible mecanismo de miocarditis posterior a la vacunación contra el COVID-19.
Describimos el caso clínico de una mujer de 72 años con dolor torácico pleurítico una semana después de la tercera vacuna de ARNm BNT162b2. Las pruebas serológicas para patógenos cardiotrópos fueron negativas y el cribado de autoinmunidad fue positivo con anticuerpos antinucleares (ANA) en dilución 1:160, anticuerpos anti-ADN de doble cadena (anti-dsADN) y antihistonas. La tomografía por emisión de positrones/tomografía computarizada (PET/TC) con 18F-fluorodesoxiglucosa (FDG) mostró un proceso inflamatorio miocárdico y pericárdico focal en el ápex cardíaco.
Se realizó el diagnóstico de lupus eritematoso sistémico (LES) con afectación miocárdica. Hasta donde sabemos, este es el primer reporte de un caso de miocarditis lúpica después de la vacuna contra el COVID-19.
Dadas las justificaciones patogénicas, se debe considerar la asociación entre lupus eritematoso sistémico (LES) y miocarditis.</abstract><cop>Spain</cop><pub>Elsevier España, S.L.U</pub><pmid>36739118</pmid><doi>10.1016/j.reumae.2022.06.006</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Ad26COVS1 Aged Antibodies, Antinuclear ARN mensajero BNT162B2 BNT162 Vaccine BNT162B2 messenger RNA Case Report COVID-19 - prevention & control COVID-19 vaccination COVID-19 Vaccines - adverse effects Female Humans Lupus eritematoso sistémico Lupus Erythematosus, Systemic - diagnosis Miocarditis Myocarditis Myocarditis - diagnosis Myocarditis - etiology Positron Emission Tomography Computed Tomography Systemic lupus erythematosus Vaccination Vacunación COVID-19 |
| title | Systemic lupus erythematosus myocarditis after COVID-19 vaccination |
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