Transcriptomic analyses of joint tissues during osteoarthritis development in a rat model reveal dysregulated mechanotransduction and extracellular matrix pathways

Transcriptomic changes in joint tissues during the development of osteoarthritis (OA) are of interest for the discovery of biomarkers and mechanisms of disease. The objective of this study was to use the rat medial meniscus transection (MMT) model to discover stage and tissue-specific transcriptomic...

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Veröffentlicht in:	Osteoarthritis and cartilage 2023-02, Vol.31 (2), p.199-212
Hauptverfasser:	Hu, Y., Li, K., Swahn, H., Ordoukhanian, P., Head, S.R., Natarajan, P., Woods, A.K., Joseph, S.B., Johnson, K.A., Lotz, M.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cartilage, Articular - pathology Disease Models, Animal Extracellular Matrix - metabolism Humans Ion Channels - metabolism Mechanotransduction Mechanotransduction, Cellular Osteoarthritis Osteoarthritis - metabolism Rats RNA - metabolism RNA sequencing Synovial Membrane - metabolism Transcriptome TRPV Cation Channels - metabolism
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