Design of a chimeric ACE-2/Fc-silent fusion protein with ultrahigh affinity and neutralizing capacity for SARS-CoV-2 variants

Abstract Background As SARS-CoV-2 continues to mutate into Variants of Concern (VOC), there is growing and urgent need to develop effective antivirals to combat COVID-19. Monoclonal antibodies developed earlier are no longer capable of effectively neutralizing currently active VOCs. This report desc...

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Veröffentlicht in:	Antibody Therapeutics 2023-01, Vol.6 (1), p.59-74
Hauptverfasser:	Bodie, Neil M, Hashimoto, Rina, Connolly, David, Chu, Jennifer, Takayama, Kazuo, Uhal, Bruce D
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Angiotensin Antiviral agents Coronaviruses Enzymes Health aspects Immunoglobulin G Medical research Medicine, Experimental Monoclonal antibodies Viral proteins
Online-Zugang:	Volltext
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