Urolithin A ameliorates obesity-induced metabolic cardiomyopathy in mice via mitophagy activation

Metabolic cardiomyopathy (MC) is characterized by intracellular lipid accumulation and utilizing fatty acids as a foremost energy source, thereby leading to excess oxidative stress and mitochondrial dysfunction. There is no effective therapy available yet. In this study we investigated whether defec...

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Veröffentlicht in:	Acta pharmacologica Sinica 2023-02, Vol.44 (2), p.321-331
Hauptverfasser:	Huang, Jian-rong, Zhang, Ming-hua, Chen, Ying-jie, Sun, Yu-ling, Gao, Zhi-min, Li, Zhuo-jia, Zhang, Gui-ping, Qin, Yuan, Dai, Xiao-yan, Yu, Xi-yong, Wu, Xiao-qian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Biomedical and Life Sciences Biomedicine Cardiomyocytes Cardiomyopathies - metabolism Cardiomyopathy Fatty acids High fat diet Immunology Internal Medicine Medical Microbiology Metabolic rate Metabolism Metabolites Mice Mice, Obese Microflora Mitochondria Mitophagy Myocytes, Cardiac - metabolism Obesity Obesity - complications Obesity - drug therapy Obesity - metabolism Oxidative stress Parkin protein Phagosomes Pharmacology/Toxicology Protein Kinases - metabolism PTEN-induced putative kinase Ubiquitin-Protein Ligases - metabolism Vaccine
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