Oxidative Stress and Pyroptosis in Doxorubicin-Induced Heart Failure and Atrial Fibrillation

Patients undergoing doxorubicin (Dox) chemotherapy often develop new-onset atrial fibrillation and heart failure. Recent studies indicate that the TLR4/MyD88/NLRP3 pyroptosis signaling pathway plays a key role in the occurrence and development of cancer, heart failure, and atherosclerosis. However,...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2023, Vol.2023, p.4938287-8
Hauptverfasser:	Ping, Zhang, Fangfang, Tou, Yuliang, Zhan, Xinyong, Cai, Lang, Hong, Fan, Hu, Jun, Ma, Liang, Shao
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Atrial Fibrillation - chemically induced Body mass index Cancer therapies Cardiac arrhythmia Cardiotoxicity Cardiovascular disease Chemotherapy Cholesterol Doxorubicin - adverse effects Heart failure Heart Failure - chemically induced High density lipoprotein Hospitals Humans Hypertension Inflammation Leukemia NLR Family, Pyrin Domain-Containing 3 Protein - genetics NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Oxidative Stress Proteins Pyroptosis Radiation Thermal cycling Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Tumors
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