Interleukin-27 Promotes Divergent Effects on HIV-1 Infection in Peripheral Blood Mononuclear Cells through BST-2/Tetherin

Interleukin-27 (IL-27) is able to inhibit HIV-1 replication in peripheral blood mononuclear cells (PBMCs), macrophages, and dendritic cells. Here, we identify that IL-27 can produce opposing effects on HIV-1 replication in PBMCs and that the HIV-1 restriction factor BST-2/Tetherin is involved in bot...

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Veröffentlicht in:	Journal of virology 2023-01, Vol.97 (1), p.e0175222-e0175222
Hauptverfasser:	Temerozo, Jairo R, Ferreira, Pedro L C, Linhares-Lacerda, Leandra, Vieira, Rhaíssa C, Cister-Alves, Bruno, Gobbo, Livia, Ribeiro-Alves, Marcelo, Menna-Barreto, Rubem F S, Bou-Habib, Dumith Chequer
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Marrow Stromal Antigen 2 HIV Infections Humans Immunology Integrins Interleukin-27 Leukocytes, Mononuclear - metabolism Pathogenesis and Immunity Viral Regulatory and Accessory Proteins
Online-Zugang:	Volltext
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