Nonproductive Hepatitis B Virus Covalently Closed Circular DNA Generates HBx-Related Transcripts from the HBx/Enhancer I Region and Acquires Reactivation by Superinfection in Single Cells

Hepatitis B virus (HBV) infection remains a public health problem worldwide. Persistent HBV infection relies on active transcription of the covalently closed circular DNA (cccDNA) in hepatocytes, which is less understood at the single-cell level. In this study, we isolated primary human hepatocytes...

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Veröffentlicht in:	Journal of virology 2023-01, Vol.97 (1), p.e0171722-e0171722
Hauptverfasser:	Peng, Bo, Jing, Zhiyi, Zhou, Zhongmin, Sun, Yinyan, Guo, Guilan, Tan, Zexi, Diao, Yan, Yao, Qiyan, Ping, Yi, Li, Xuelei, Ren, Tengfei, Li, Bin, Li, Wenhui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA, Circular - genetics DNA, Viral - genetics Editor's Pick Genome and Regulation of Viral Gene Expression Genome Replication and Regulation of Viral Gene Expression Hepatitis B virus - genetics Hepatitis B, Chronic - genetics Hepatocytes Humans Mice Superinfection Viral Regulatory and Accessory Proteins - genetics Virology Virus Replication - genetics
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