Frequency of microsatellite instability (MSI) in upper tract urothelial carcinoma: comparison of the Bethesda panel and the Idylla MSI assay in a consecutively collected, multi-institutional cohort

AimsUpper tract urothelial carcinoma (UTUC) is a rare malignancy with a poor prognosis which occurs sporadically or in few cases results from a genetic disorder called Lynch syndrome. Recently, examination of microsatellite instability (MSI) has gained importance as a biomarker: MSI tumours are asso...

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Veröffentlicht in:	Journal of clinical pathology 2023-02, Vol.76 (2), p.126-132
Hauptverfasser:	Kullmann, Friederike, Strissel, Pamela L, Strick, Reiner, Stoehr, Robert, Eckstein, Markus, Bertz, Simone, Wullich, Bernd, Sikic, Danijel, Wach, Sven, Taubert, Helge, Olbert, Peter, Heers, Hendrik, Lara, María Fernanda, Macias, Maria Luisa, Matas-Rico, Elisa, Lozano, Maria José, Prieto, Daniel, Hierro, Isabel, van Doeveren, Thomas, Bieche, Ivan, Masliah-Planchon, Julien, Beaurepere, Romane, Boormans, Joost L, Allory, Yves, Herrera-Imbroda, Bernardo, Hartmann, Arndt, Weyerer, Veronika
Format:	Artikel
Sprache:	eng
Schlagworte:	Accreditation Cancer Capillary electrophoresis Carcinoma, Transitional Cell - diagnosis Carcinoma, Transitional Cell - genetics Colorectal cancer Colorectal Neoplasms - pathology Colorectal Neoplasms, Hereditary Nonpolyposis - genetics DNA Mismatch Repair - genetics Genetic disorders Humans Medical prognosis methods Microsatellite Instability Microsatellite Repeats molecular Mutation Original Research Pathology Reproducibility Tumors Urinary Bladder Neoplasms - genetics Urological cancer urological neoplasms
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