Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice

Canagliflozin (Cana), a clinically important anti-diabetes drug, leads to a 14% increase in median lifespan and a 9% increase in the 90th percentile age when given to genetically heterogeneous male mice from 7 months of age, but does not increase lifespan in female mice. A histopathological study wa...

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Veröffentlicht in:GeroScience 2023-02, Vol.45 (1), p.385-397
Hauptverfasser: Snyder, Jessica M., Casey, Kerriann M., Galecki, Andrzej, Harrison, David E., Jayarathne, Hashan, Kumar, Navasuja, Macchiarini, Francesca, Rosenthal, Nadia, Sadagurski, Marianna, Salmon, Adam B., Strong, Randy, Miller, Richard A., Ladiges, Warren
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Sprache:eng
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