Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin

The peptide antibiotic albicidin is a DNA topoisomerase inhibitor with low-nanomolar bactericidal activity towards fluoroquinolone-resistant Gram-negative pathogens. However, its mode of action is poorly understood. We determined a 2.6 Å resolution cryoelectron microscopy structure of a ternary comp...

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Veröffentlicht in:	Nature catalysis 2023, Vol.6 (1), p.52-67
Hauptverfasser:	Michalczyk, Elizabeth, Hommernick, Kay, Behroz, Iraj, Kulike, Marcel, Pakosz-Stępień, Zuzanna, Mazurek, Lukasz, Seidel, Maria, Kunert, Maria, Santos, Karine, von Moeller, Holger, Loll, Bernhard, Weston, John B., Mainz, Andi, Heddle, Jonathan G., Süssmuth, Roderich D., Ghilarov, Dmitry
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/154/309/2420 631/154/556 631/326/22/1290 631/45/173 631/92/609 82/16 82/80 82/83 Catalysis Chemistry Chemistry and Materials Science
Online-Zugang:	Volltext
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