Cutting Edge: CCR9 Promotes CD8+ T Cell Recruitment to the Brain during Congenital Cytomegalovirus Infection
CD8+ T lymphocytes infiltrate the brain during congenital CMV infection and promote viral clearance. However, the mechanisms by which CD8+ T cells are recruited to the brain remain unclear. Using a mouse model of congenital CMV, we found a gut-homing chemokine receptor (CCR9) was preferentially expr...
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Veröffentlicht in: | The Journal of immunology (1950) 2022-12, Vol.209 (12), p.2281-2286 |
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container_title | The Journal of immunology (1950) |
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creator | Hilt, Zachary T Charles, Wisler Cheng, Katarina E Tabilas, Cybelle Steinhilber, Megan Wesnak, Samantha P Smith, Norah L Schaffer, Chris B Rudd, Brian D |
description | CD8+ T lymphocytes infiltrate the brain during congenital CMV infection and promote viral clearance. However, the mechanisms by which CD8+ T cells are recruited to the brain remain unclear. Using a mouse model of congenital CMV, we found a gut-homing chemokine receptor (CCR9) was preferentially expressed in CD8+ T cells localized in the brain postinfection. In the absence of CCR9 or CCL25 (CCR9's ligand) expression, CD8+ T cells failed to migrate to key sites of infection in the brain and protect the host from severe forms of disease. Interestingly, we found that expression of CCR9 on CD8+ T cells was also responsible for spatial temporal positioning of T cells in the brain. Collectively, our data demonstrate that the CMV-infected brain uses a similar mechanism for CD8+ T cell homing as the small intestine. |
doi_str_mv | 10.4049/jimmunol.2200578 |
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However, the mechanisms by which CD8+ T cells are recruited to the brain remain unclear. Using a mouse model of congenital CMV, we found a gut-homing chemokine receptor (CCR9) was preferentially expressed in CD8+ T cells localized in the brain postinfection. In the absence of CCR9 or CCL25 (CCR9's ligand) expression, CD8+ T cells failed to migrate to key sites of infection in the brain and protect the host from severe forms of disease. Interestingly, we found that expression of CCR9 on CD8+ T cells was also responsible for spatial temporal positioning of T cells in the brain. Collectively, our data demonstrate that the CMV-infected brain uses a similar mechanism for CD8+ T cell homing as the small intestine.</description><subject>Brain - metabolism</subject><subject>CD8-Positive T-Lymphocytes - metabolism</subject><subject>Cytomegalovirus Infections - metabolism</subject><subject>Humans</subject><subject>Intestine, Small - metabolism</subject><subject>Receptors, CCR - metabolism</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM1LwzAYxoMobk7vniR36UyTNB8eBI1TBwNlzHNJ26yLtMlI08H-ezv8QE_P4eX58f4eAC5TNKWIypsP27a9880UY4QyLo7AOM0ylDCG2DEYI4RxknLGR-Cs6z4QQgxhegpGhFEmBSVj0Kg-RutqOKtqcwuVWkr4Fnzro-mgehTXcAWVaRq4NGXobWyNizB6GDcGPgRtHaz6cOgr72rjbNQNVPvoW1Prxu9s6Ds4d2tTRuvdOThZ66YzF985Ae9Ps5V6SRavz3N1v0i2KSMxYUgWGceVKCmVZWaoYKTU2UFQp0amnJRkzQuDC2kGHyG4FhgJNFjzokrXZALuvrjbvmhNVQ4_B93k22BbHfa51zb_f3F2k9d-l0shGOZ0AFz9Bfw2f3Yjn6GlceM</recordid><startdate>20221215</startdate><enddate>20221215</enddate><creator>Hilt, Zachary T</creator><creator>Charles, Wisler</creator><creator>Cheng, Katarina E</creator><creator>Tabilas, Cybelle</creator><creator>Steinhilber, Megan</creator><creator>Wesnak, Samantha P</creator><creator>Smith, Norah L</creator><creator>Schaffer, Chris B</creator><creator>Rudd, Brian D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1988-7196</orcidid><orcidid>https://orcid.org/0000-0002-0519-6319</orcidid><orcidid>https://orcid.org/0000-0001-5846-7269</orcidid><orcidid>https://orcid.org/0000-0003-3445-7570</orcidid><orcidid>https://orcid.org/0000-0002-7495-7660</orcidid><orcidid>https://orcid.org/0000-0002-7800-9596</orcidid></search><sort><creationdate>20221215</creationdate><title>Cutting Edge: CCR9 Promotes CD8+ T Cell Recruitment to the Brain during Congenital Cytomegalovirus Infection</title><author>Hilt, Zachary T ; Charles, Wisler ; Cheng, Katarina E ; Tabilas, Cybelle ; Steinhilber, Megan ; Wesnak, Samantha P ; Smith, Norah L ; Schaffer, Chris B ; Rudd, Brian D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p163t-609b572d8c449c5e4863ca50578a1e9173c3f7be2b9e024887a820806607bd1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Brain - metabolism</topic><topic>CD8-Positive T-Lymphocytes - metabolism</topic><topic>Cytomegalovirus Infections - metabolism</topic><topic>Humans</topic><topic>Intestine, Small - metabolism</topic><topic>Receptors, CCR - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hilt, Zachary T</creatorcontrib><creatorcontrib>Charles, Wisler</creatorcontrib><creatorcontrib>Cheng, Katarina E</creatorcontrib><creatorcontrib>Tabilas, Cybelle</creatorcontrib><creatorcontrib>Steinhilber, Megan</creatorcontrib><creatorcontrib>Wesnak, Samantha P</creatorcontrib><creatorcontrib>Smith, Norah L</creatorcontrib><creatorcontrib>Schaffer, Chris B</creatorcontrib><creatorcontrib>Rudd, Brian D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hilt, Zachary T</au><au>Charles, Wisler</au><au>Cheng, Katarina E</au><au>Tabilas, Cybelle</au><au>Steinhilber, Megan</au><au>Wesnak, Samantha P</au><au>Smith, Norah L</au><au>Schaffer, Chris B</au><au>Rudd, Brian D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cutting Edge: CCR9 Promotes CD8+ T Cell Recruitment to the Brain during Congenital Cytomegalovirus Infection</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>2022-12-15</date><risdate>2022</risdate><volume>209</volume><issue>12</issue><spage>2281</spage><epage>2286</epage><pages>2281-2286</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>CD8+ T lymphocytes infiltrate the brain during congenital CMV infection and promote viral clearance. 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subjects | Brain - metabolism CD8-Positive T-Lymphocytes - metabolism Cytomegalovirus Infections - metabolism Humans Intestine, Small - metabolism Receptors, CCR - metabolism |
title | Cutting Edge: CCR9 Promotes CD8+ T Cell Recruitment to the Brain during Congenital Cytomegalovirus Infection |
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