BODIPY-Caged Photoactivated Inhibitors of Cathepsin B Flip the Light Switch on Cancer Cell Apoptosis

Acquired resistance to apoptotic agents is a long-standing challenge in cancer treatment. Cathepsin B (CTSB) is an enzyme which, among many essential functions, promotes apoptosis during cellular stress through regulation of intracellular proteolytic networks on the minute time scale. Recent data in...

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Veröffentlicht in:	ACS chemical biology 2019-12, Vol.14 (12), p.2833-2840
Hauptverfasser:	Toupin, Nicholas P, Arora, Karan, Shrestha, Pradeep, Peterson, Julie A, Fischer, Logan J, Rajagurubandara, Erandi, Podgorski, Izabela, Winter, Arthur H, Kodanko, Jeremy J
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Boron Compounds - chemistry Cathepsin B - antagonists & inhibitors Cell Line, Tumor Cysteine Proteinase Inhibitors - chemistry Cysteine Proteinase Inhibitors - pharmacology Humans Light Neoplasms - pathology Oxidative Stress
Online-Zugang:	Volltext
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