Association of Fibrinogen With Ischemic Stroke: A Systematic Review and Meta-Analysis
Validation of a risk factor in a multifactorial disease like ischemic stroke is necessary to practice precision medicine. Many risk factors have been attributed to causing ischemic stroke but contribute very little to it. There are many risk factors that need to be validated, and fibrinogen is one s...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2023-01, Vol.15 (1), p.e34335-e34335 |
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| creator | Prasad, Manoj K Marandi, Sujeet Mishra, Brajesh Guria, Rishi T Kumar, Amit Birua, Hirendra Ray, Hemant N Dungdung, Ajit Kumar, Divakar Maitra, Shubham |
| description | Validation of a risk factor in a multifactorial disease like ischemic stroke is necessary to practice precision medicine. Many risk factors have been attributed to causing ischemic stroke but contribute very little to it. There are many risk factors that need to be validated, and fibrinogen is one such risk factor. Using a meta-analysis technique, we investigated fibrinogen as a risk factor for ischemic stroke. We searched the computerized databases such as PubMed, Google Scholar, and Cochrane to explore articles on ischemic stroke. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random effects model. A total of 10 case-control studies with 6877 cases and 7219 controls were included in the study that match inclusion and exclusion criteria. The Asiatic population was portrayed in four studies, whereas the Caucasian population was portrayed in six studies. Under the recessive model, an elevated level of serum fibrinogen is linked to an increased risk of ischemic stroke as shown by pooled odds ratio (OR: 1.47, 95% CI: 1.19-1.76, I
= 78.3%, P = 0.000). Our meta-analysis concluded that a high level of fibrinogen is associated with an increased risk of ischemic stroke. |
| doi_str_mv | 10.7759/cureus.34335 |
| format | Article |
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= 78.3%, P = 0.000). Our meta-analysis concluded that a high level of fibrinogen is associated with an increased risk of ischemic stroke.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.34335</identifier><identifier>PMID: 36721710</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Alcohol ; Atherosclerosis ; Automation ; Body mass index ; Cardiovascular disease ; Cholesterol ; Diabetes ; Emergency Medicine ; Ethnicity ; High density lipoprotein ; Hypertension ; Internal Medicine ; Lipoproteins ; Meta-analysis ; Neurology ; Plasma ; Precision medicine ; Risk factors ; Stroke ; Systematic review</subject><ispartof>Curēus (Palo Alto, CA), 2023-01, Vol.15 (1), p.e34335-e34335</ispartof><rights>Copyright © 2023, Prasad et al.</rights><rights>Copyright © 2023, Prasad et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023, Prasad et al. 2023 Prasad et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-1154c2ac667fbd28a3dccce6f09023fc7ad0d7ddbb80af4ed4b54ccf132b186a3</citedby><cites>FETCH-LOGICAL-c342t-1154c2ac667fbd28a3dccce6f09023fc7ad0d7ddbb80af4ed4b54ccf132b186a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884496/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884496/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36721710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prasad, Manoj K</creatorcontrib><creatorcontrib>Marandi, Sujeet</creatorcontrib><creatorcontrib>Mishra, Brajesh</creatorcontrib><creatorcontrib>Guria, Rishi T</creatorcontrib><creatorcontrib>Kumar, Amit</creatorcontrib><creatorcontrib>Birua, Hirendra</creatorcontrib><creatorcontrib>Ray, Hemant N</creatorcontrib><creatorcontrib>Dungdung, Ajit</creatorcontrib><creatorcontrib>Kumar, Divakar</creatorcontrib><creatorcontrib>Maitra, Shubham</creatorcontrib><title>Association of Fibrinogen With Ischemic Stroke: A Systematic Review and Meta-Analysis</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Validation of a risk factor in a multifactorial disease like ischemic stroke is necessary to practice precision medicine. Many risk factors have been attributed to causing ischemic stroke but contribute very little to it. There are many risk factors that need to be validated, and fibrinogen is one such risk factor. Using a meta-analysis technique, we investigated fibrinogen as a risk factor for ischemic stroke. We searched the computerized databases such as PubMed, Google Scholar, and Cochrane to explore articles on ischemic stroke. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random effects model. A total of 10 case-control studies with 6877 cases and 7219 controls were included in the study that match inclusion and exclusion criteria. The Asiatic population was portrayed in four studies, whereas the Caucasian population was portrayed in six studies. Under the recessive model, an elevated level of serum fibrinogen is linked to an increased risk of ischemic stroke as shown by pooled odds ratio (OR: 1.47, 95% CI: 1.19-1.76, I
= 78.3%, P = 0.000). Our meta-analysis concluded that a high level of fibrinogen is associated with an increased risk of ischemic stroke.</description><subject>Alcohol</subject><subject>Atherosclerosis</subject><subject>Automation</subject><subject>Body mass index</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Diabetes</subject><subject>Emergency Medicine</subject><subject>Ethnicity</subject><subject>High density lipoprotein</subject><subject>Hypertension</subject><subject>Internal Medicine</subject><subject>Lipoproteins</subject><subject>Meta-analysis</subject><subject>Neurology</subject><subject>Plasma</subject><subject>Precision medicine</subject><subject>Risk factors</subject><subject>Stroke</subject><subject>Systematic review</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkUtLxDAUhYMoKurOtQTcuLCa1zSpC2EQHwOK4AOXIU1unWjbaNIq8--tzijq6l643zncw0Fom5IDKUfFoe0j9OmAC85HS2id0Vxliiqx_GtfQ1spPRFCKJGMSLKK1nguGZWUrKP7cUrBetP50OJQ4TNfRt-GR2jxg--meJLsFBpv8W0XwzMc4TG-naUOmkFh8Q28eXjHpnX4CjqTjVtTz5JPm2ilMnWCrcXcQPdnp3cnF9nl9fnkZHyZWS5Yl1E6EpYZm-eyKh1ThjtrLeQVKQjjlZXGESedK0tFTCXAiXIQ2IpyVlKVG76Bjue-L33ZgLPQdtHU-iX6xsSZDsbrv5fWT_VjeNOFUkIU-WCwtzCI4bWH1OnGJwt1bVoIfdJMSprzQio6oLv_0KfQxyHwnGKCS84Han9O2RhSilD9PEOJ_qxMzyvTX5UN-M7vAD_wd0H8A2WblGw</recordid><startdate>20230129</startdate><enddate>20230129</enddate><creator>Prasad, Manoj K</creator><creator>Marandi, Sujeet</creator><creator>Mishra, Brajesh</creator><creator>Guria, Rishi T</creator><creator>Kumar, Amit</creator><creator>Birua, Hirendra</creator><creator>Ray, Hemant N</creator><creator>Dungdung, Ajit</creator><creator>Kumar, Divakar</creator><creator>Maitra, Shubham</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230129</creationdate><title>Association of Fibrinogen With Ischemic Stroke: A Systematic Review and Meta-Analysis</title><author>Prasad, Manoj K ; Marandi, Sujeet ; Mishra, Brajesh ; Guria, Rishi T ; Kumar, Amit ; Birua, Hirendra ; Ray, Hemant N ; Dungdung, Ajit ; Kumar, Divakar ; Maitra, Shubham</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-1154c2ac667fbd28a3dccce6f09023fc7ad0d7ddbb80af4ed4b54ccf132b186a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alcohol</topic><topic>Atherosclerosis</topic><topic>Automation</topic><topic>Body mass index</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Diabetes</topic><topic>Emergency Medicine</topic><topic>Ethnicity</topic><topic>High density lipoprotein</topic><topic>Hypertension</topic><topic>Internal Medicine</topic><topic>Lipoproteins</topic><topic>Meta-analysis</topic><topic>Neurology</topic><topic>Plasma</topic><topic>Precision medicine</topic><topic>Risk factors</topic><topic>Stroke</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prasad, Manoj K</creatorcontrib><creatorcontrib>Marandi, Sujeet</creatorcontrib><creatorcontrib>Mishra, Brajesh</creatorcontrib><creatorcontrib>Guria, Rishi T</creatorcontrib><creatorcontrib>Kumar, Amit</creatorcontrib><creatorcontrib>Birua, Hirendra</creatorcontrib><creatorcontrib>Ray, Hemant N</creatorcontrib><creatorcontrib>Dungdung, Ajit</creatorcontrib><creatorcontrib>Kumar, Divakar</creatorcontrib><creatorcontrib>Maitra, Shubham</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prasad, Manoj K</au><au>Marandi, Sujeet</au><au>Mishra, Brajesh</au><au>Guria, Rishi T</au><au>Kumar, Amit</au><au>Birua, Hirendra</au><au>Ray, Hemant N</au><au>Dungdung, Ajit</au><au>Kumar, Divakar</au><au>Maitra, Shubham</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Fibrinogen With Ischemic Stroke: A Systematic Review and Meta-Analysis</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2023-01-29</date><risdate>2023</risdate><volume>15</volume><issue>1</issue><spage>e34335</spage><epage>e34335</epage><pages>e34335-e34335</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Validation of a risk factor in a multifactorial disease like ischemic stroke is necessary to practice precision medicine. Many risk factors have been attributed to causing ischemic stroke but contribute very little to it. There are many risk factors that need to be validated, and fibrinogen is one such risk factor. Using a meta-analysis technique, we investigated fibrinogen as a risk factor for ischemic stroke. We searched the computerized databases such as PubMed, Google Scholar, and Cochrane to explore articles on ischemic stroke. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random effects model. A total of 10 case-control studies with 6877 cases and 7219 controls were included in the study that match inclusion and exclusion criteria. The Asiatic population was portrayed in four studies, whereas the Caucasian population was portrayed in six studies. Under the recessive model, an elevated level of serum fibrinogen is linked to an increased risk of ischemic stroke as shown by pooled odds ratio (OR: 1.47, 95% CI: 1.19-1.76, I
= 78.3%, P = 0.000). Our meta-analysis concluded that a high level of fibrinogen is associated with an increased risk of ischemic stroke.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>36721710</pmid><doi>10.7759/cureus.34335</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Curēus (Palo Alto, CA), 2023-01, Vol.15 (1), p.e34335-e34335 |
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| source | PubMed Central; PubMed Central Open Access |
| subjects | Alcohol Atherosclerosis Automation Body mass index Cardiovascular disease Cholesterol Diabetes Emergency Medicine Ethnicity High density lipoprotein Hypertension Internal Medicine Lipoproteins Meta-analysis Neurology Plasma Precision medicine Risk factors Stroke Systematic review |
| title | Association of Fibrinogen With Ischemic Stroke: A Systematic Review and Meta-Analysis |
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