Pharmacogenetic testing for NAT2 genotypes in a Tanzanian population across the lifespan to guide future personalized isoniazid dosing

Despite updated recommendations for weight-based isoniazid dosing in children with drug-susceptible tuberculosis (TB) and higher dose isoniazid in regimens for adults with drug-resistant TB, individual pharmacokinetic variability can lead to sub-target isoniazid exposure. Host pharmacogenetics and i...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2022-09, Vol.136, p.102246-102246, Article 102246
Hauptverfasser:	Masiphephethu, Maano V., Sariko, Margaretha, Walongo, Thomas, Maro, Athanasia, Mduma, Dorcus, Gratz, Jean, Alshaer, Mohammad, Peloquin, Charles A., Mduma, Estomih, Mpagama, Stellah G., Thomas, Tania, Houpt, Eric R., Traore, Afsatou, Bessong, Pascal, Heysell, Scott K., Operario, Darwin J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adult Antitubercular Agents - therapeutic use Arylamine N-Acetyltransferase - genetics Child Genotype Humans Isoniazid Isoniazid - therapeutic use Longevity Mycobacterium tuberculosis N-acetyltransferase Pharmacogenetics Pharmacogenomic Testing Pharmacokinetics Polymorphism, Single Nucleotide Tanzania Tuberculosis - genetics
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