Prognostic and Immunological Potential of Ribonucleotide Reductase Subunits in Liver Cancer

Background. Ribonucleotide reductase (RR) consists of two subunits, the large subunit RRM1 and the small subunit (RRM2 or RRM2B), which is essential for DNA replication. Dysregulations of RR were implicated in multiple types of cancer. However, the abnormal expressions and biologic functions of RR s...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2023, Vol.2023, p.3878796-14
Hauptverfasser:	Yin, Xin, Jiang, Kan, Zhou, Ziyang, Yu, Hao, Yan, Danfang, He, Xingkang, Yan, Senxiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer therapies Cell cycle Cell Line, Tumor Clinical significance Correlation analysis Cyclin-dependent kinases Datasets Gene amplification Humans Kinases Liver cancer Liver Neoplasms - genetics Lung cancer Medical prognosis Mitochondrial DNA Mutation Prognosis Ribonucleoside Diphosphate Reductase - genetics Ribonucleoside Diphosphate Reductase - metabolism Ribonucleotide reductase Ribonucleotide Reductases - genetics Ribonucleotide Reductases - metabolism Transcription factors Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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