Detection of Immune Microenvironment Changes and Immune-Related Regulators in Langerhans Cell Histiocytosis Bone Metastasis
The inflammation/immune response pathway is considered a key contributor to the development of Langerhans cell histiocytosis (LCH) bone metastasis. However, the dynamic changes in the immune microenvironment of LCH bone metastasis and critical regulators are still unclear. Expression profiling by ar...
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| description | The inflammation/immune response pathway is considered a key contributor to the development of Langerhans cell histiocytosis (LCH) bone metastasis. However, the dynamic changes in the immune microenvironment of LCH bone metastasis and critical regulators are still unclear. Expression profiling by arrays of GSE16395, GSE35340, and GSE122476 was applied to detect the immune microenvironment changes in the development of LCH bone metastasis. The single-cell high-throughput sequencing of GSE133704, involved in LCH bone lesions, was analyzed. The online database Metascape and gene set variation analysis (GSVA) algorithms were used to detect the gene function of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). The protein–protein interaction (PPI) network of hub regulators was constructed by the STRING database. In these results, key immune cells, such as Tem cells, NK T cells, CD8(+) T cells, and Th1 cells, were identified in LCH bone metastasis. These genes, which include LAG3, TSPAN5, LPAR5, VEGFA, CXCL16, CD74, and MARCKS, may significantly correlate with the cellular infiltration of B cells, aDCs, pDCs, cytotoxic cells, T cells, CD8+ T cells, T helper cells, and Tcm cells. In conclusion, our study constructed an atlas of the immune microenvironment of LCH bone metastasis. Genes including LAG3, TSPAN5, LPAR5, VEGFA, CXCL16, CD74, and MARCKS may be involved in the development of LCH bone metastasis. The hub gene-immune cell interactive map may be a potential prognostic biomarker for the progression of LCH bone metastasis and synergetic targets for immunotherapy in LCH patients. |
| doi_str_mv | 10.1155/2023/1447435 |
| format | Article |
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However, the dynamic changes in the immune microenvironment of LCH bone metastasis and critical regulators are still unclear. Expression profiling by arrays of GSE16395, GSE35340, and GSE122476 was applied to detect the immune microenvironment changes in the development of LCH bone metastasis. The single-cell high-throughput sequencing of GSE133704, involved in LCH bone lesions, was analyzed. The online database Metascape and gene set variation analysis (GSVA) algorithms were used to detect the gene function of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). The protein–protein interaction (PPI) network of hub regulators was constructed by the STRING database. In these results, key immune cells, such as Tem cells, NK T cells, CD8(+) T cells, and Th1 cells, were identified in LCH bone metastasis. These genes, which include LAG3, TSPAN5, LPAR5, VEGFA, CXCL16, CD74, and MARCKS, may significantly correlate with the cellular infiltration of B cells, aDCs, pDCs, cytotoxic cells, T cells, CD8+ T cells, T helper cells, and Tcm cells. In conclusion, our study constructed an atlas of the immune microenvironment of LCH bone metastasis. Genes including LAG3, TSPAN5, LPAR5, VEGFA, CXCL16, CD74, and MARCKS may be involved in the development of LCH bone metastasis. The hub gene-immune cell interactive map may be a potential prognostic biomarker for the progression of LCH bone metastasis and synergetic targets for immunotherapy in LCH patients.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2023/1447435</identifier><identifier>PMID: 36714021</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Algorithms ; Autoimmune diseases ; Biomarkers ; Biomarkers - metabolism ; Bone cancer ; Bone lesions ; Bone Neoplasms - genetics ; CD8 antigen ; CD8-Positive T-Lymphocytes - metabolism ; Complications and side effects ; Correlation analysis ; CXCL16 protein ; Cytotoxicity ; Dendritic cells ; Development and progression ; Encyclopedias ; Gene expression ; Genes ; Genomes ; Health aspects ; Helper cells ; Histiocytosis ; Histiocytosis, Langerhans-Cell - diagnosis ; Histiocytosis, Langerhans-Cell - genetics ; Humans ; Immune response ; Immune system ; Immunologic Factors ; Immunotherapy ; Kinases ; Langerhans cell histiocytosis ; Lymphocytes ; Lymphocytes B ; Lymphocytes T ; MARCKS protein ; Metastases ; Metastasis ; Microenvironments ; Mutation ; Next-generation sequencing ; Protein Interaction Maps - genetics ; Proteins ; Risk factors ; Senescence ; Tumor Microenvironment - genetics</subject><ispartof>BioMed research international, 2023, Vol.2023 (1), p.1447435-1447435</ispartof><rights>Copyright © 2023 Jinding Lin et al.</rights><rights>COPYRIGHT 2023 John Wiley & Sons, Inc.</rights><rights>Copyright © 2023 Jinding Lin et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2023 Jinding Lin et al. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-90cce005a5f06963b8e6cbdf21e67d4eae4218cb33668b99b61895767335dca53</citedby><cites>FETCH-LOGICAL-c476t-90cce005a5f06963b8e6cbdf21e67d4eae4218cb33668b99b61895767335dca53</cites><orcidid>0000-0002-1856-538X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879691/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879691/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36714021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ergün, Sercan</contributor><contributor>Sercan Ergün</contributor><creatorcontrib>Lin, Jinding</creatorcontrib><creatorcontrib>Tang, Haifeng</creatorcontrib><creatorcontrib>Xu, Zhitong</creatorcontrib><creatorcontrib>Zeng, Rongdong</creatorcontrib><title>Detection of Immune Microenvironment Changes and Immune-Related Regulators in Langerhans Cell Histiocytosis Bone Metastasis</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>The inflammation/immune response pathway is considered a key contributor to the development of Langerhans cell histiocytosis (LCH) bone metastasis. However, the dynamic changes in the immune microenvironment of LCH bone metastasis and critical regulators are still unclear. Expression profiling by arrays of GSE16395, GSE35340, and GSE122476 was applied to detect the immune microenvironment changes in the development of LCH bone metastasis. The single-cell high-throughput sequencing of GSE133704, involved in LCH bone lesions, was analyzed. The online database Metascape and gene set variation analysis (GSVA) algorithms were used to detect the gene function of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). The protein–protein interaction (PPI) network of hub regulators was constructed by the STRING database. In these results, key immune cells, such as Tem cells, NK T cells, CD8(+) T cells, and Th1 cells, were identified in LCH bone metastasis. These genes, which include LAG3, TSPAN5, LPAR5, VEGFA, CXCL16, CD74, and MARCKS, may significantly correlate with the cellular infiltration of B cells, aDCs, pDCs, cytotoxic cells, T cells, CD8+ T cells, T helper cells, and Tcm cells. In conclusion, our study constructed an atlas of the immune microenvironment of LCH bone metastasis. Genes including LAG3, TSPAN5, LPAR5, VEGFA, CXCL16, CD74, and MARCKS may be involved in the development of LCH bone metastasis. The hub gene-immune cell interactive map may be a potential prognostic biomarker for the progression of LCH bone metastasis and synergetic targets for immunotherapy in LCH patients.</description><subject>Algorithms</subject><subject>Autoimmune diseases</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Bone cancer</subject><subject>Bone lesions</subject><subject>Bone Neoplasms - genetics</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes - metabolism</subject><subject>Complications and side effects</subject><subject>Correlation analysis</subject><subject>CXCL16 protein</subject><subject>Cytotoxicity</subject><subject>Dendritic cells</subject><subject>Development and progression</subject><subject>Encyclopedias</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genomes</subject><subject>Health aspects</subject><subject>Helper cells</subject><subject>Histiocytosis</subject><subject>Histiocytosis, Langerhans-Cell - diagnosis</subject><subject>Histiocytosis, Langerhans-Cell - genetics</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunologic Factors</subject><subject>Immunotherapy</subject><subject>Kinases</subject><subject>Langerhans cell histiocytosis</subject><subject>Lymphocytes</subject><subject>Lymphocytes B</subject><subject>Lymphocytes T</subject><subject>MARCKS protein</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Microenvironments</subject><subject>Mutation</subject><subject>Next-generation sequencing</subject><subject>Protein Interaction Maps - genetics</subject><subject>Proteins</subject><subject>Risk factors</subject><subject>Senescence</subject><subject>Tumor Microenvironment - genetics</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1rFDEchoMottTePEvAi2DH5mOSTC5C3aotrAhFzyGT-c1uykxSk5lK8Z83w67rx8GQkEAenuTlReg5JW8oFeKcEcbPaV2rmotH6JhxWleS1vTx4cz5ETrN-ZaU0VBJtHyKjrhUtCaMHqMflzCBm3wMOPb4ehznAPiTdylCuPcphhHChFdbGzaQsQ3dnqluYLATdPgGNnM5xZSxD3i9cKnQGa9gGPCVz8XtHqaYfcbv4iKHyeYyfX6GnvR2yHC630_Q1w_vv6yuqvXnj9eri3XlaiWnShPngBBhRU-klrxtQLq26xkFqboaLNSMNq7lXMqm1bqVtNFCScW56JwV_AS93Xnv5naEzpVEyQ7mLvnRpgcTrTd_3wS_NZt4b3SjtNS0CF7tBSl-myFPZvTZlXw2QJyzYUpR0kjNVEFf_oPexjmFEm-hiOBlNb-pjR3A-NDH8q5bpOZCcUEZE1QX6mxHlTZyTtAfvkyJWeo3S_1mX3_BX_wZ8wD_KrsAr3fA1ofOfvf_1_0EzAW3qg</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Lin, Jinding</creator><creator>Tang, Haifeng</creator><creator>Xu, Zhitong</creator><creator>Zeng, Rongdong</creator><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1856-538X</orcidid></search><sort><creationdate>2023</creationdate><title>Detection of Immune Microenvironment Changes and Immune-Related Regulators in Langerhans Cell Histiocytosis Bone Metastasis</title><author>Lin, Jinding ; Tang, Haifeng ; Xu, Zhitong ; Zeng, Rongdong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-90cce005a5f06963b8e6cbdf21e67d4eae4218cb33668b99b61895767335dca53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Algorithms</topic><topic>Autoimmune diseases</topic><topic>Biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Bone cancer</topic><topic>Bone lesions</topic><topic>Bone Neoplasms - genetics</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes - metabolism</topic><topic>Complications and side effects</topic><topic>Correlation analysis</topic><topic>CXCL16 protein</topic><topic>Cytotoxicity</topic><topic>Dendritic cells</topic><topic>Development and progression</topic><topic>Encyclopedias</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genomes</topic><topic>Health aspects</topic><topic>Helper cells</topic><topic>Histiocytosis</topic><topic>Histiocytosis, Langerhans-Cell - diagnosis</topic><topic>Histiocytosis, Langerhans-Cell - genetics</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunologic Factors</topic><topic>Immunotherapy</topic><topic>Kinases</topic><topic>Langerhans cell histiocytosis</topic><topic>Lymphocytes</topic><topic>Lymphocytes B</topic><topic>Lymphocytes T</topic><topic>MARCKS protein</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Microenvironments</topic><topic>Mutation</topic><topic>Next-generation sequencing</topic><topic>Protein Interaction Maps - genetics</topic><topic>Proteins</topic><topic>Risk factors</topic><topic>Senescence</topic><topic>Tumor Microenvironment - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Jinding</creatorcontrib><creatorcontrib>Tang, Haifeng</creatorcontrib><creatorcontrib>Xu, Zhitong</creatorcontrib><creatorcontrib>Zeng, Rongdong</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Jinding</au><au>Tang, Haifeng</au><au>Xu, Zhitong</au><au>Zeng, Rongdong</au><au>Ergün, Sercan</au><au>Sercan Ergün</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of Immune Microenvironment Changes and Immune-Related Regulators in Langerhans Cell Histiocytosis Bone Metastasis</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2023</date><risdate>2023</risdate><volume>2023</volume><issue>1</issue><spage>1447435</spage><epage>1447435</epage><pages>1447435-1447435</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>The inflammation/immune response pathway is considered a key contributor to the development of Langerhans cell histiocytosis (LCH) bone metastasis. However, the dynamic changes in the immune microenvironment of LCH bone metastasis and critical regulators are still unclear. Expression profiling by arrays of GSE16395, GSE35340, and GSE122476 was applied to detect the immune microenvironment changes in the development of LCH bone metastasis. The single-cell high-throughput sequencing of GSE133704, involved in LCH bone lesions, was analyzed. The online database Metascape and gene set variation analysis (GSVA) algorithms were used to detect the gene function of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). The protein–protein interaction (PPI) network of hub regulators was constructed by the STRING database. In these results, key immune cells, such as Tem cells, NK T cells, CD8(+) T cells, and Th1 cells, were identified in LCH bone metastasis. These genes, which include LAG3, TSPAN5, LPAR5, VEGFA, CXCL16, CD74, and MARCKS, may significantly correlate with the cellular infiltration of B cells, aDCs, pDCs, cytotoxic cells, T cells, CD8+ T cells, T helper cells, and Tcm cells. In conclusion, our study constructed an atlas of the immune microenvironment of LCH bone metastasis. Genes including LAG3, TSPAN5, LPAR5, VEGFA, CXCL16, CD74, and MARCKS may be involved in the development of LCH bone metastasis. The hub gene-immune cell interactive map may be a potential prognostic biomarker for the progression of LCH bone metastasis and synergetic targets for immunotherapy in LCH patients.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>36714021</pmid><doi>10.1155/2023/1447435</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-1856-538X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Algorithms Autoimmune diseases Biomarkers Biomarkers - metabolism Bone cancer Bone lesions Bone Neoplasms - genetics CD8 antigen CD8-Positive T-Lymphocytes - metabolism Complications and side effects Correlation analysis CXCL16 protein Cytotoxicity Dendritic cells Development and progression Encyclopedias Gene expression Genes Genomes Health aspects Helper cells Histiocytosis Histiocytosis, Langerhans-Cell - diagnosis Histiocytosis, Langerhans-Cell - genetics Humans Immune response Immune system Immunologic Factors Immunotherapy Kinases Langerhans cell histiocytosis Lymphocytes Lymphocytes B Lymphocytes T MARCKS protein Metastases Metastasis Microenvironments Mutation Next-generation sequencing Protein Interaction Maps - genetics Proteins Risk factors Senescence Tumor Microenvironment - genetics |
| title | Detection of Immune Microenvironment Changes and Immune-Related Regulators in Langerhans Cell Histiocytosis Bone Metastasis |
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