Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles

The non-canonical inflammasome sensor caspase-11 and gasdermin D (GSDMD) drive inflammation and pyroptosis, a type of immunogenic cell death that favors cell-mediated immunity (CMI) in cancer, infection, and autoimmunity. Here we show that caspase-11 and GSDMD are required for CD8 and Th1 responses...

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Veröffentlicht in:	Cell reports. Medicine 2023-01, Vol.4 (1), p.100899, Article 100899
Hauptverfasser:	Muñoz-Wolf, Natalia, Ward, Ross W, Hearnden, Claire H, Sharp, Fiona A, Geoghegan, Joan, O'Grady, Katie, McEntee, Craig P, Shanahan, Katharine A, Guy, Coralie, Bowie, Andrew G, Campbell, Matthew, Roces, Carla B, Anderluzzi, Giulia, Webb, Cameron, Perrie, Yvonne, Creagh, Emma, Lavelle, Ed C
Format:	Artikel
Sprache:	eng
Schlagworte:	Caspases - metabolism Inflammasomes - metabolism Interleukin-1 - metabolism Interleukin-18 - metabolism Intracellular Signaling Peptides and Proteins - metabolism Nanoparticles Phosphate-Binding Proteins - metabolism Reactive Oxygen Species - metabolism
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