Effect of leukocyte and platelet-rich fibrin on free gingival graft healing: A clinical and histological study in rabbits
Recently, the use of leukocyte- and platelet-rich fibrin (L-PRF) has been recommended due to the presence of various growth factors to increase the success of free gingival grafts (FGG). This study evaluated the effect of using L-PRF in the healing of FGG in rabbits. Twenty rabbits were randomly div...
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| Veröffentlicht in: | Journal of advanced periodontology and implant dentistry 2022, Vol.14 (2), p.89-96 |
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| creator | Mogharehabed, Ahmad Torabinia, Nakisa Sharifi Darani, Sare Afshari, Zohreh Yaghini, Jaber |
| description | Recently, the use of leukocyte- and platelet-rich fibrin (L-PRF) has been recommended due to the presence of various growth factors to increase the success of free gingival grafts (FGG). This study evaluated the effect of using L-PRF in the healing of FGG in rabbits.
Twenty rabbits were randomly divided into two groups. In each group, FGG was performed in two separate sites with or without L-PRF. One of these groups was sacrificed on the 7th day and the other on the 28th day and analyzed in terms of clinical indices, including wound healing, gingi-val thickness (GT), and keratinized tissue width (KTW). Then histologic sections were obtained and stained for type and degree of inflammation and rate of vascular formation analysis. SPSS 22 was used for statistical analysis.
The extent of changes in GT, KTW, wound healing index, and vascular formation between the test and control groups was not statistically significant. The difference in the type of inflammation was significant only between the -7day and -28day control groups (P=0.003). The degree of inflammation between the -7day test group and the -28day control group, as well as the -7day and -28day control groups, were statistically significant (P=0.011 and P=0.002, respectively).
Using L-PRF with FGG could improve FGG healing compared to using FGG alone, but the results were not statistically significant. |
| doi_str_mv | 10.34172/japid.2022.011 |
| format | Article |
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Twenty rabbits were randomly divided into two groups. In each group, FGG was performed in two separate sites with or without L-PRF. One of these groups was sacrificed on the 7th day and the other on the 28th day and analyzed in terms of clinical indices, including wound healing, gingi-val thickness (GT), and keratinized tissue width (KTW). Then histologic sections were obtained and stained for type and degree of inflammation and rate of vascular formation analysis. SPSS 22 was used for statistical analysis.
The extent of changes in GT, KTW, wound healing index, and vascular formation between the test and control groups was not statistically significant. The difference in the type of inflammation was significant only between the -7day and -28day control groups (P=0.003). The degree of inflammation between the -7day test group and the -28day control group, as well as the -7day and -28day control groups, were statistically significant (P=0.011 and P=0.002, respectively).
Using L-PRF with FGG could improve FGG healing compared to using FGG alone, but the results were not statistically significant.</description><identifier>ISSN: 2645-5390</identifier><identifier>ISSN: 2008-7748</identifier><identifier>EISSN: 2645-5390</identifier><identifier>EISSN: 2008-7756</identifier><identifier>DOI: 10.34172/japid.2022.011</identifier><identifier>PMID: 36714079</identifier><language>eng</language><publisher>Iran: Tabriz University of Medical Sciences</publisher><subject>Angiogenesis ; Animals ; Edema ; Erythema ; Fibrin ; Growth factors ; Inflammation ; l-prf ; Palate ; Statistical analysis ; Surgery ; Sutures ; Systematic review ; tissue grafts ; Vascular endothelial growth factor ; Wound healing</subject><ispartof>Journal of advanced periodontology and implant dentistry, 2022, Vol.14 (2), p.89-96</ispartof><rights>2022 The Author(s).</rights><rights>2022. This work is published under http://dentistry.tbzmed.ac.ir/jpid/index.php/jpid/about/editorialPolicies#openAccessPolicy (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 The Author(s). 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4021-893cbbf91fddabf31c4ddb6037c02900eb53241428bff078605cb3b93e302cf53</citedby><cites>FETCH-LOGICAL-c4021-893cbbf91fddabf31c4ddb6037c02900eb53241428bff078605cb3b93e302cf53</cites><orcidid>0000-0002-2343-3867 ; 0000-0003-0967-8961 ; 0000-0003-1775-3343 ; 0000-0002-5678-8365</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871186/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871186/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,4009,27902,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36714079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mogharehabed, Ahmad</creatorcontrib><creatorcontrib>Torabinia, Nakisa</creatorcontrib><creatorcontrib>Sharifi Darani, Sare</creatorcontrib><creatorcontrib>Afshari, Zohreh</creatorcontrib><creatorcontrib>Yaghini, Jaber</creatorcontrib><title>Effect of leukocyte and platelet-rich fibrin on free gingival graft healing: A clinical and histological study in rabbits</title><title>Journal of advanced periodontology and implant dentistry</title><addtitle>J Adv Periodontol Implant Dent</addtitle><description>Recently, the use of leukocyte- and platelet-rich fibrin (L-PRF) has been recommended due to the presence of various growth factors to increase the success of free gingival grafts (FGG). This study evaluated the effect of using L-PRF in the healing of FGG in rabbits.
Twenty rabbits were randomly divided into two groups. In each group, FGG was performed in two separate sites with or without L-PRF. One of these groups was sacrificed on the 7th day and the other on the 28th day and analyzed in terms of clinical indices, including wound healing, gingi-val thickness (GT), and keratinized tissue width (KTW). Then histologic sections were obtained and stained for type and degree of inflammation and rate of vascular formation analysis. SPSS 22 was used for statistical analysis.
The extent of changes in GT, KTW, wound healing index, and vascular formation between the test and control groups was not statistically significant. The difference in the type of inflammation was significant only between the -7day and -28day control groups (P=0.003). The degree of inflammation between the -7day test group and the -28day control group, as well as the -7day and -28day control groups, were statistically significant (P=0.011 and P=0.002, respectively).
Using L-PRF with FGG could improve FGG healing compared to using FGG alone, but the results were not statistically significant.</description><subject>Angiogenesis</subject><subject>Animals</subject><subject>Edema</subject><subject>Erythema</subject><subject>Fibrin</subject><subject>Growth factors</subject><subject>Inflammation</subject><subject>l-prf</subject><subject>Palate</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Sutures</subject><subject>Systematic review</subject><subject>tissue grafts</subject><subject>Vascular endothelial growth factor</subject><subject>Wound healing</subject><issn>2645-5390</issn><issn>2008-7748</issn><issn>2645-5390</issn><issn>2008-7756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNpdks1rVDEUxR-i2FK7dicBN27eNN95z4VQStVCwY2uQz7fZMy8jEleYf57MzO1tK5yOffkd2_C6br3CK4IRQJfbdQu2BWGGK8gQq-6c8wp6xkZ4etn9Vl3WcoGQogHwRhkb7szwgWiUIzn3f7We2cqSB5Et_xOZl8dULMFu6iqi672OZg18EHnMIM0A5-dA1OYp_CgIpiy8hWsnYpN-QyugWlFMK1zYKxDqSmm6SiUutg9aJCstA61vOveeBWLu3w8L7pfX29_3nzv7398u7u5vu8NhRj1w0iM1n5E3lqlPUGGWqs5JMJAPELoNCOYIooH7T0UA4fMaKJH4gjExjNy0d2duDapjdzlsFV5L5MK8iikPEmVazDRSc_aMGadcmagyrc9OedKIUGxGTSljfXlxNoteuuscXPNKr6AvuzMYS2n9CDHQSA08Ab49AjI6c_iSpXbUIyLUc0uLUViIRAc-DDiZv34n3WTljy3r2ouPnLMODq4rk4uk1Mp2fmnZRCUx5TIY0rkISWypaTd-PD8DU_-f5kgfwHzSbq6</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Mogharehabed, Ahmad</creator><creator>Torabinia, Nakisa</creator><creator>Sharifi Darani, Sare</creator><creator>Afshari, Zohreh</creator><creator>Yaghini, Jaber</creator><general>Tabriz University of Medical Sciences</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2343-3867</orcidid><orcidid>https://orcid.org/0000-0003-0967-8961</orcidid><orcidid>https://orcid.org/0000-0003-1775-3343</orcidid><orcidid>https://orcid.org/0000-0002-5678-8365</orcidid></search><sort><creationdate>2022</creationdate><title>Effect of leukocyte and platelet-rich fibrin on free gingival graft healing: A clinical and histological study in rabbits</title><author>Mogharehabed, Ahmad ; Torabinia, Nakisa ; Sharifi Darani, Sare ; Afshari, Zohreh ; Yaghini, Jaber</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4021-893cbbf91fddabf31c4ddb6037c02900eb53241428bff078605cb3b93e302cf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Angiogenesis</topic><topic>Animals</topic><topic>Edema</topic><topic>Erythema</topic><topic>Fibrin</topic><topic>Growth factors</topic><topic>Inflammation</topic><topic>l-prf</topic><topic>Palate</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Sutures</topic><topic>Systematic review</topic><topic>tissue grafts</topic><topic>Vascular endothelial growth factor</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mogharehabed, Ahmad</creatorcontrib><creatorcontrib>Torabinia, Nakisa</creatorcontrib><creatorcontrib>Sharifi Darani, Sare</creatorcontrib><creatorcontrib>Afshari, Zohreh</creatorcontrib><creatorcontrib>Yaghini, Jaber</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of advanced periodontology and implant dentistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mogharehabed, Ahmad</au><au>Torabinia, Nakisa</au><au>Sharifi Darani, Sare</au><au>Afshari, Zohreh</au><au>Yaghini, Jaber</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of leukocyte and platelet-rich fibrin on free gingival graft healing: A clinical and histological study in rabbits</atitle><jtitle>Journal of advanced periodontology and implant dentistry</jtitle><addtitle>J Adv Periodontol Implant Dent</addtitle><date>2022</date><risdate>2022</risdate><volume>14</volume><issue>2</issue><spage>89</spage><epage>96</epage><pages>89-96</pages><issn>2645-5390</issn><issn>2008-7748</issn><eissn>2645-5390</eissn><eissn>2008-7756</eissn><abstract>Recently, the use of leukocyte- and platelet-rich fibrin (L-PRF) has been recommended due to the presence of various growth factors to increase the success of free gingival grafts (FGG). This study evaluated the effect of using L-PRF in the healing of FGG in rabbits.
Twenty rabbits were randomly divided into two groups. In each group, FGG was performed in two separate sites with or without L-PRF. One of these groups was sacrificed on the 7th day and the other on the 28th day and analyzed in terms of clinical indices, including wound healing, gingi-val thickness (GT), and keratinized tissue width (KTW). Then histologic sections were obtained and stained for type and degree of inflammation and rate of vascular formation analysis. SPSS 22 was used for statistical analysis.
The extent of changes in GT, KTW, wound healing index, and vascular formation between the test and control groups was not statistically significant. The difference in the type of inflammation was significant only between the -7day and -28day control groups (P=0.003). The degree of inflammation between the -7day test group and the -28day control group, as well as the -7day and -28day control groups, were statistically significant (P=0.011 and P=0.002, respectively).
Using L-PRF with FGG could improve FGG healing compared to using FGG alone, but the results were not statistically significant.</abstract><cop>Iran</cop><pub>Tabriz University of Medical Sciences</pub><pmid>36714079</pmid><doi>10.34172/japid.2022.011</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2343-3867</orcidid><orcidid>https://orcid.org/0000-0003-0967-8961</orcidid><orcidid>https://orcid.org/0000-0003-1775-3343</orcidid><orcidid>https://orcid.org/0000-0002-5678-8365</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Angiogenesis Animals Edema Erythema Fibrin Growth factors Inflammation l-prf Palate Statistical analysis Surgery Sutures Systematic review tissue grafts Vascular endothelial growth factor Wound healing |
| title | Effect of leukocyte and platelet-rich fibrin on free gingival graft healing: A clinical and histological study in rabbits |
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