Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells

The effectiveness of chimaeric antigen receptor (CAR) T-cell immunotherapies against solid tumours relies on the accumulation, proliferation and persistency of T cells at the tumour site. Here we show that the proliferation of CD8αβ cytotoxic CAR T cells in solid tumours can be enhanced by deriving...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature biomedical engineering 2023-01, Vol.7 (1), p.24-37
Hauptverfasser:	Ueda, Tatsuki, Shiina, Sara, Iriguchi, Shoichi, Terakura, Seitaro, Kawai, Yohei, Kabai, Ryotaro, Sakamoto, Satoko, Watanabe, Akira, Ohara, Kohei, Wang, Bo, Xu, Huaigeng, Minagawa, Atsutaka, Hotta, Akitsu, Woltjen, Knut, Uemura, Yasushi, Kodama, Yuzo, Seno, Hiroshi, Nakatsura, Tetsuya, Tamada, Koji, Kaneko, Shin
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/21 13/31 59/5 631/61/2320 631/67/1059/2325 Animal models Animals Antigens Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine CD8 antigen CD8-Positive T-Lymphocytes Cell Proliferation Chimeric antigen receptors Cytotoxicity Diacylglycerol kinase Effector cells Genetic engineering Humans Immunotherapy Induced Pluripotent Stem Cells - pathology Interleukin 15 Kinases Lymphocytes Lymphocytes T Neoplasms - therapy Optimization Pluripotency Receptors Receptors, Antigen, T-Cell - genetics Solid tumors Stem cell transplantation Stem cells Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!