Replication fork uncoupling causes nascent strand degradation and fork reversal

Genotoxins cause nascent strand degradation (NSD) and fork reversal during DNA replication. NSD and fork reversal are crucial for genome stability and are exploited by chemotherapeutic approaches. However, it is unclear how NSD and fork reversal are triggered. Additionally, the fate of the replicati...

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Veröffentlicht in:	Nature structural & molecular biology 2023-01, Vol.30 (1), p.115-124
Hauptverfasser:	Kavlashvili, Tamar, Liu, Wenpeng, Mohamed, Taha M., Cortez, David, Dewar, James M.
Format:	Artikel
Sprache:	eng
Schlagworte:	14/1 14/63 38/22 42/109 42/89 45/22 631/337/1427/2566 631/337/151/1431 631/337/151/2353 631/337/151/2356 64/114 82/1 82/29 Animals Biochemistry Biological Microscopy Biomedical and Life Sciences Degradation Deoxyribonucleic acid DNA DNA biosynthesis DNA helicase DNA Helicases - metabolism DNA polymerase DNA Replication DNA-Binding Proteins - metabolism Genomes Genomic Instability Humans Life Sciences Membrane Biology Molecular biology Protein Structure Replication Replication forks Xenopus laevis - metabolism
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