Deceased-Donor Acute Kidney Injury and Acute Rejection in Kidney Transplant Recipients: A Multicenter Cohort

Donor acute kidney injury (AKI) activates innate immunity, enhances HLA expression in the kidney allograft, and provokes recipient alloimmune responses. We hypothesized that injury and inflammation that manifested in deceased-donor urine biomarkers would be associated with higher rates of biopsy-pro...

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Veröffentlicht in:	American journal of kidney diseases 2023-02, Vol.81 (2), p.222-231.e1
Hauptverfasser:	Reese, Peter P., Doshi, Mona D., Hall, Isaac E., Besharatian, Behdad, Bromberg, Jonathan S., Thiessen-Philbrook, Heather, Jia, Yaqi, Kamoun, Malek, Mansour, Sherry G., Akalin, Enver, Harhay, Meera N., Mohan, Sumit, Muthukumar, Thangamani, Schröppel, Bernd, Singh, Pooja, Weng, Francis L., Parikh, Chirag R.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute kidney injury (AKI) Acute Kidney Injury - pathology Adult Aged Biomarkers biopsy-proven acute rejection (BPAR) de novo DSA deceased organ donation donor-specific antibody (DSA) graft failure Graft Rejection - epidemiology Graft Survival Humans inflammation injury hypothesis Interleukin-18 Kidney Transplantation Lipocalin-2 Middle Aged organ acceptance Prospective Studies Tissue Donors
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