Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates

Soluble adenylyl cyclase (sAC: ADCY10) is an enzyme involved in intracellular signaling. Inhibition of sAC has potential therapeutic utility in a number of areas. For example, sAC is integral to successful male fertility: sAC activation is required for sperm motility and ability to undergo the acros...

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Veröffentlicht in:	Journal of medicinal chemistry 2022-11, Vol.65 (22), p.15208-15226
Hauptverfasser:	Miller, Michael, Rossetti, Thomas, Ferreira, Jacob, Ghanem, Lubna, Balbach, Melanie, Kaur, Navpreet, Levin, Lonny R., Buck, Jochen, Kehr, Maria, Coquille, Sandrine, van den Heuvel, Joop, Steegborn, Clemens, Fushimi, Makoto, Finkin-Groner, Efrat, Myers, Robert W., Kargman, Stacia, Liverton, Nigel J., Huggins, David J., Meinke, Peter T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - drug effects Adenylyl Cyclases - metabolism Animals Contraceptive Agents, Male - chemistry Contraceptive Agents, Male - pharmacology Male Oocytes - metabolism Signal Transduction - physiology Sperm Motility - drug effects
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