Inhibition of ANO1 by Cis - and Trans -Resveratrol and Their Anticancer Activity in Human Prostate Cancer PC-3 Cells
Anoctamin1 (ANO1), a calcium-activated chloride channel, is involved in the proliferation, migration, and invasion of various cancer cells including head and neck squamous cell carcinoma, lung cancer, and prostate cancer. Inhibition of ANO1 activity or downregulation of ANO1 expression in these canc...
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| Veröffentlicht in: | International journal of molecular sciences 2023-01, Vol.24 (2), p.1186 |
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| creator | Jeon, Dongkyu Jo, Minjae Lee, Yechan Park, So-Hyeon Phan, Hong Thi Lam Nam, Joo Hyun Namkung, Wan |
| description | Anoctamin1 (ANO1), a calcium-activated chloride channel, is involved in the proliferation, migration, and invasion of various cancer cells including head and neck squamous cell carcinoma, lung cancer, and prostate cancer. Inhibition of ANO1 activity or downregulation of ANO1 expression in these cancer cells is known to exhibit anticancer effects. Resveratrol, a natural polyphenol abundant in wines, grapes, berries, soybeans, and peanuts, shows a wide variety of biological effects including anti-inflammatory, antioxidant, and anticancer activities. In this study, we investigated the effects of two stereoisomers of resveratrol on ANO1 activity and found that
- and
-resveratrol inhibited ANO1 activity with different potencies.
- and
-resveratrol inhibited ANO1 channel activity with IC
values of 10.6 and 102 μM, respectively, and had no significant effect on intracellular calcium signaling at 10 and 100 μM, respectively. In addition,
-resveratrol downregulated mRNA and protein expression levels of ANO1 more potently than
-resveratrol in PC-3 prostate cancer cells.
- and
-resveratrol significantly reduced cell proliferation and cell migration in an ANO1-dependent manner, and both resveratrol isomers strongly increased caspase-3 activity, PARP cleavage, and apoptotic sub-G1 phase ratio in PC-3 cells. These results revealed that
-resveratrol is a potent inhibitor of ANO1 and exhibits ANO1-dependent anticancer activity against human metastatic prostate cancer PC-3 cells. |
| doi_str_mv | 10.3390/ijms24021186 |
| format | Article |
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- and
-resveratrol inhibited ANO1 activity with different potencies.
- and
-resveratrol inhibited ANO1 channel activity with IC
values of 10.6 and 102 μM, respectively, and had no significant effect on intracellular calcium signaling at 10 and 100 μM, respectively. In addition,
-resveratrol downregulated mRNA and protein expression levels of ANO1 more potently than
-resveratrol in PC-3 prostate cancer cells.
- and
-resveratrol significantly reduced cell proliferation and cell migration in an ANO1-dependent manner, and both resveratrol isomers strongly increased caspase-3 activity, PARP cleavage, and apoptotic sub-G1 phase ratio in PC-3 cells. These results revealed that
-resveratrol is a potent inhibitor of ANO1 and exhibits ANO1-dependent anticancer activity against human metastatic prostate cancer PC-3 cells.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24021186</identifier><identifier>PMID: 36674697</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Anoctamin-1 - metabolism ; Antitumor activity ; Apoptosis ; Biological effects ; Calcium ; Calcium (intracellular) ; Calcium chloride ; Calcium signalling ; Caspase-3 ; Cell adhesion & migration ; Cell growth ; Cell proliferation ; Channel gating ; Chloride ; Chloride channels (calcium-gated) ; G1 phase ; Gene expression ; Head & neck cancer ; Head and Neck Neoplasms ; Humans ; Inflammation ; Intracellular signalling ; Investigations ; Isomers ; Lung cancer ; Lung carcinoma ; Male ; Metastases ; Metastasis ; mRNA ; Neoplasm Proteins - metabolism ; Pancreatic cancer ; PC-3 Cells ; Phase ratio ; Prostate cancer ; Prostatic Neoplasms - drug therapy ; Prostatic Neoplasms - metabolism ; Protein expression ; Proteins ; Resveratrol ; Resveratrol - pharmacology ; Squamous cell carcinoma ; Stereoisomerism ; Stereoisomers</subject><ispartof>International journal of molecular sciences, 2023-01, Vol.24 (2), p.1186</ispartof><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-9c9d54ab2d0ebd1fbe02aab0b77fa80d0d1bb07dfc09238af7f3f547ea2a74b23</citedby><cites>FETCH-LOGICAL-c412t-9c9d54ab2d0ebd1fbe02aab0b77fa80d0d1bb07dfc09238af7f3f547ea2a74b23</cites><orcidid>0000-0003-0414-6245 ; 0000-0002-1339-6388 ; 0000-0001-8300-6974 ; 0000-0001-9203-6489 ; 0000-0002-1480-7433 ; 0000-0002-5694-1972 ; 0000-0002-3224-6510</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862168/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9862168/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36674697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeon, Dongkyu</creatorcontrib><creatorcontrib>Jo, Minjae</creatorcontrib><creatorcontrib>Lee, Yechan</creatorcontrib><creatorcontrib>Park, So-Hyeon</creatorcontrib><creatorcontrib>Phan, Hong Thi Lam</creatorcontrib><creatorcontrib>Nam, Joo Hyun</creatorcontrib><creatorcontrib>Namkung, Wan</creatorcontrib><title>Inhibition of ANO1 by Cis - and Trans -Resveratrol and Their Anticancer Activity in Human Prostate Cancer PC-3 Cells</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Anoctamin1 (ANO1), a calcium-activated chloride channel, is involved in the proliferation, migration, and invasion of various cancer cells including head and neck squamous cell carcinoma, lung cancer, and prostate cancer. Inhibition of ANO1 activity or downregulation of ANO1 expression in these cancer cells is known to exhibit anticancer effects. Resveratrol, a natural polyphenol abundant in wines, grapes, berries, soybeans, and peanuts, shows a wide variety of biological effects including anti-inflammatory, antioxidant, and anticancer activities. In this study, we investigated the effects of two stereoisomers of resveratrol on ANO1 activity and found that
- and
-resveratrol inhibited ANO1 activity with different potencies.
- and
-resveratrol inhibited ANO1 channel activity with IC
values of 10.6 and 102 μM, respectively, and had no significant effect on intracellular calcium signaling at 10 and 100 μM, respectively. In addition,
-resveratrol downregulated mRNA and protein expression levels of ANO1 more potently than
-resveratrol in PC-3 prostate cancer cells.
- and
-resveratrol significantly reduced cell proliferation and cell migration in an ANO1-dependent manner, and both resveratrol isomers strongly increased caspase-3 activity, PARP cleavage, and apoptotic sub-G1 phase ratio in PC-3 cells. These results revealed that
-resveratrol is a potent inhibitor of ANO1 and exhibits ANO1-dependent anticancer activity against human metastatic prostate cancer PC-3 cells.</description><subject>Anoctamin-1 - metabolism</subject><subject>Antitumor activity</subject><subject>Apoptosis</subject><subject>Biological effects</subject><subject>Calcium</subject><subject>Calcium (intracellular)</subject><subject>Calcium chloride</subject><subject>Calcium signalling</subject><subject>Caspase-3</subject><subject>Cell adhesion & migration</subject><subject>Cell growth</subject><subject>Cell proliferation</subject><subject>Channel gating</subject><subject>Chloride</subject><subject>Chloride channels (calcium-gated)</subject><subject>G1 phase</subject><subject>Gene expression</subject><subject>Head & neck cancer</subject><subject>Head and Neck Neoplasms</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Intracellular signalling</subject><subject>Investigations</subject><subject>Isomers</subject><subject>Lung cancer</subject><subject>Lung carcinoma</subject><subject>Male</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>mRNA</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Pancreatic cancer</subject><subject>PC-3 Cells</subject><subject>Phase ratio</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Resveratrol</subject><subject>Resveratrol - pharmacology</subject><subject>Squamous cell carcinoma</subject><subject>Stereoisomerism</subject><subject>Stereoisomers</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkc1r3DAQxUVoadK0t5yDoJcc6lYfXsu-BBaTNIHQhJKexUiWslpsKZHkhf3vq2XTsO1JD82Px7x5CJ1R8o3zjnx36ymxmjBK2-YIndCasYqQRrw70MfoY0prQhhni-4DOuZNI-qmEyco3_qVUy674HGwePnznmK1xb1LuMLgB_wYwRf9y6SNiZBjGPffK-MiXvrsNHhtitTZbVzeYufxzTyBxw8xpAzZ4H5PPPQVx70Zx_QJvbcwJvP59T1Fv6-vHvub6u7-x22_vKt0TVmuOt0NixoUG4hRA7XKEAagiBLCQksGMlCliBisJh3jLVhhuV3UwgADUSvGT9Hl3vd5VpMZtPE5wiifo5sgbmUAJ_-deLeST2Eju7ZhtGmLwcWrQQwvs0lZTi7pEgG8CXOSTDRtualY0IJ--Q9dhzn6Em9HCcZ3foX6uqd0OU6Kxr4tQ4nc1SkP6yz4-WGAN_hvf_wPktSbyQ</recordid><startdate>20230107</startdate><enddate>20230107</enddate><creator>Jeon, Dongkyu</creator><creator>Jo, Minjae</creator><creator>Lee, Yechan</creator><creator>Park, So-Hyeon</creator><creator>Phan, Hong Thi Lam</creator><creator>Nam, Joo Hyun</creator><creator>Namkung, Wan</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0414-6245</orcidid><orcidid>https://orcid.org/0000-0002-1339-6388</orcidid><orcidid>https://orcid.org/0000-0001-8300-6974</orcidid><orcidid>https://orcid.org/0000-0001-9203-6489</orcidid><orcidid>https://orcid.org/0000-0002-1480-7433</orcidid><orcidid>https://orcid.org/0000-0002-5694-1972</orcidid><orcidid>https://orcid.org/0000-0002-3224-6510</orcidid></search><sort><creationdate>20230107</creationdate><title>Inhibition of ANO1 by Cis - and Trans -Resveratrol and Their Anticancer Activity in Human Prostate Cancer PC-3 Cells</title><author>Jeon, Dongkyu ; Jo, Minjae ; Lee, Yechan ; Park, So-Hyeon ; Phan, Hong Thi Lam ; Nam, Joo Hyun ; Namkung, Wan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-9c9d54ab2d0ebd1fbe02aab0b77fa80d0d1bb07dfc09238af7f3f547ea2a74b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anoctamin-1 - metabolism</topic><topic>Antitumor activity</topic><topic>Apoptosis</topic><topic>Biological effects</topic><topic>Calcium</topic><topic>Calcium (intracellular)</topic><topic>Calcium chloride</topic><topic>Calcium signalling</topic><topic>Caspase-3</topic><topic>Cell adhesion & migration</topic><topic>Cell growth</topic><topic>Cell proliferation</topic><topic>Channel gating</topic><topic>Chloride</topic><topic>Chloride channels (calcium-gated)</topic><topic>G1 phase</topic><topic>Gene expression</topic><topic>Head & neck cancer</topic><topic>Head and Neck Neoplasms</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Intracellular signalling</topic><topic>Investigations</topic><topic>Isomers</topic><topic>Lung cancer</topic><topic>Lung carcinoma</topic><topic>Male</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>mRNA</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Pancreatic cancer</topic><topic>PC-3 Cells</topic><topic>Phase ratio</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>Resveratrol</topic><topic>Resveratrol - pharmacology</topic><topic>Squamous cell carcinoma</topic><topic>Stereoisomerism</topic><topic>Stereoisomers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeon, Dongkyu</creatorcontrib><creatorcontrib>Jo, Minjae</creatorcontrib><creatorcontrib>Lee, Yechan</creatorcontrib><creatorcontrib>Park, So-Hyeon</creatorcontrib><creatorcontrib>Phan, Hong Thi Lam</creatorcontrib><creatorcontrib>Nam, Joo Hyun</creatorcontrib><creatorcontrib>Namkung, Wan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeon, Dongkyu</au><au>Jo, Minjae</au><au>Lee, Yechan</au><au>Park, So-Hyeon</au><au>Phan, Hong Thi Lam</au><au>Nam, Joo Hyun</au><au>Namkung, Wan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of ANO1 by Cis - and Trans -Resveratrol and Their Anticancer Activity in Human Prostate Cancer PC-3 Cells</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2023-01-07</date><risdate>2023</risdate><volume>24</volume><issue>2</issue><spage>1186</spage><pages>1186-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Anoctamin1 (ANO1), a calcium-activated chloride channel, is involved in the proliferation, migration, and invasion of various cancer cells including head and neck squamous cell carcinoma, lung cancer, and prostate cancer. Inhibition of ANO1 activity or downregulation of ANO1 expression in these cancer cells is known to exhibit anticancer effects. Resveratrol, a natural polyphenol abundant in wines, grapes, berries, soybeans, and peanuts, shows a wide variety of biological effects including anti-inflammatory, antioxidant, and anticancer activities. In this study, we investigated the effects of two stereoisomers of resveratrol on ANO1 activity and found that
- and
-resveratrol inhibited ANO1 activity with different potencies.
- and
-resveratrol inhibited ANO1 channel activity with IC
values of 10.6 and 102 μM, respectively, and had no significant effect on intracellular calcium signaling at 10 and 100 μM, respectively. In addition,
-resveratrol downregulated mRNA and protein expression levels of ANO1 more potently than
-resveratrol in PC-3 prostate cancer cells.
- and
-resveratrol significantly reduced cell proliferation and cell migration in an ANO1-dependent manner, and both resveratrol isomers strongly increased caspase-3 activity, PARP cleavage, and apoptotic sub-G1 phase ratio in PC-3 cells. These results revealed that
-resveratrol is a potent inhibitor of ANO1 and exhibits ANO1-dependent anticancer activity against human metastatic prostate cancer PC-3 cells.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36674697</pmid><doi>10.3390/ijms24021186</doi><orcidid>https://orcid.org/0000-0003-0414-6245</orcidid><orcidid>https://orcid.org/0000-0002-1339-6388</orcidid><orcidid>https://orcid.org/0000-0001-8300-6974</orcidid><orcidid>https://orcid.org/0000-0001-9203-6489</orcidid><orcidid>https://orcid.org/0000-0002-1480-7433</orcidid><orcidid>https://orcid.org/0000-0002-5694-1972</orcidid><orcidid>https://orcid.org/0000-0002-3224-6510</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2023-01, Vol.24 (2), p.1186 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9862168 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Anoctamin-1 - metabolism Antitumor activity Apoptosis Biological effects Calcium Calcium (intracellular) Calcium chloride Calcium signalling Caspase-3 Cell adhesion & migration Cell growth Cell proliferation Channel gating Chloride Chloride channels (calcium-gated) G1 phase Gene expression Head & neck cancer Head and Neck Neoplasms Humans Inflammation Intracellular signalling Investigations Isomers Lung cancer Lung carcinoma Male Metastases Metastasis mRNA Neoplasm Proteins - metabolism Pancreatic cancer PC-3 Cells Phase ratio Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Protein expression Proteins Resveratrol Resveratrol - pharmacology Squamous cell carcinoma Stereoisomerism Stereoisomers |
| title | Inhibition of ANO1 by Cis - and Trans -Resveratrol and Their Anticancer Activity in Human Prostate Cancer PC-3 Cells |
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