Long-Term Safety of Growth Hormone Deficiency Treatment in Cancer and Sellar Tumors Adult Survivors: Is There a Role of GH Therapy on the Neoplastic Risk?
Experimental studies support the hypothesis that GH/IGF-1 status may influence neoplastic tissue growth. Epidemiological studies suggest a link between GH/IGF-1 status and cancer risk. However, several studies regarding GH replacement safety in childhood cancer survivors do not show a prevalence exc...
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| Veröffentlicht in: | Journal of clinical medicine 2023-01, Vol.12 (2), p.662 |
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| container_title | Journal of clinical medicine |
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| creator | Di Somma, Carolina Scarano, Elisabetta Arianna, Rossana Romano, Fiammetta Lavorgna, Mariarosaria Serpico, Domenico Colao, Annamaria |
| description | Experimental studies support the hypothesis that GH/IGF-1 status may influence neoplastic tissue growth. Epidemiological studies suggest a link between GH/IGF-1 status and cancer risk. However, several studies regarding GH replacement safety in childhood cancer survivors do not show a prevalence excess of de novo cancers, and several reports on children and adults treated with GH have not shown an increase in observed cancer risk in these patients. The aim of this review is to provide an at-a-glance overview and the state of the art of long-term effects of GH replacement on neoplastic risk in adults with growth hormone deficiency who have survived cancer and sellar tumors. |
| doi_str_mv | 10.3390/jcm12020662 |
| format | Article |
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Epidemiological studies suggest a link between GH/IGF-1 status and cancer risk. However, several studies regarding GH replacement safety in childhood cancer survivors do not show a prevalence excess of de novo cancers, and several reports on children and adults treated with GH have not shown an increase in observed cancer risk in these patients. 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| subjects | Adults Apoptosis Breast cancer Cancer therapies Cell division Clinical medicine Colorectal cancer Estrogens Growth hormones Insulin-like growth factors Medical research Mortality Prostate Radiation Review Risk factors Tumors |
| title | Long-Term Safety of Growth Hormone Deficiency Treatment in Cancer and Sellar Tumors Adult Survivors: Is There a Role of GH Therapy on the Neoplastic Risk? |
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