Anti-mesothelin immunotoxin induces mesothelioma eradication, anti-tumor immunity, and the development of tertiary lymphoid structures

LMB-100 is a recombinant immunotoxin composed of a Fab linked to a toxin. It kills cells expressing human mesothelin (hMSLN), which is highly expressed on the surface of mesothelioma and many other cancer cells. Clinically, we observed some patients had delayed responses to an anti-hMSLN immunotoxin...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-11, Vol.119 (48), p.1-12
Hauptverfasser:	Liu, Wenlong, Tai, Chin-Hsien, Liu, Xiufen, Pastan, Ira
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal Biological Sciences CD4 antigen CD8 antigen CD8-Positive T-Lymphocytes Cell death Chemokines Chemotaxis Cytokines Gene expression Humans Immune system Immunity Immunohistochemistry Immunotoxins Immunotoxins - genetics Immunotoxins - pharmacology Lymphocytes Lymphocytes B Lymphocytes T Mesothelin Mesothelioma Mesothelioma - drug therapy Mesothelioma - genetics Mesothelioma, Malignant Mice Mice, Transgenic Microenvironments Protein arrays Tertiary Lymphoid Structures Toxins Transgenic mice Tumor cells Tumor Microenvironment Tumors
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