The Role of miRNAs, circRNAs and Their Interactions in Development and Progression of Hepatocellular Carcinoma: An Insilico Approach
Hepatocellular carcinoma (HCC) is a type of malignant tumor. miRNAs are noncoding RNAs and their differential expression patterns are observed in HCC-induced by alcoholism, HBV and HCV infections. By acting as a competing endogenous RNA (ceRNA), circRNA regulates the miRNA function, indirectly contr...
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| Veröffentlicht in: | Genes 2022-12, Vol.14 (1), p.13 |
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| creator | Ishaq, Yasmeen Ikram, Aqsa Alzahrani, Badr Khurshid, Sana |
| description | Hepatocellular carcinoma (HCC) is a type of malignant tumor. miRNAs are noncoding RNAs and their differential expression patterns are observed in HCC-induced by alcoholism, HBV and HCV infections. By acting as a competing endogenous RNA (ceRNA), circRNA regulates the miRNA function, indirectly controlling the gene expression and leading to HCC progression. In the present study, data mining was performed to screen out all miRNAs and circRNA involved in alcohol, HBV or HCV-induced HCC with statistically significant (≤0.05%) expression levels reported in various studies. Further, the interaction of miRNAs and circRNA was also investigated to explore their role in HCC due to various causative agents. Together, these study data provide a deeper understanding of the circRNA-miRNA regulatory mechanisms in HCC. These screened circRNA, miRNA and their interactions can be used as prognostic biomarkers or therapeutic targets for the treatment of HCC. |
| doi_str_mv | 10.3390/genes14010013 |
| format | Article |
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By acting as a competing endogenous RNA (ceRNA), circRNA regulates the miRNA function, indirectly controlling the gene expression and leading to HCC progression. In the present study, data mining was performed to screen out all miRNAs and circRNA involved in alcohol, HBV or HCV-induced HCC with statistically significant (≤0.05%) expression levels reported in various studies. Further, the interaction of miRNAs and circRNA was also investigated to explore their role in HCC due to various causative agents. Together, these study data provide a deeper understanding of the circRNA-miRNA regulatory mechanisms in HCC. These screened circRNA, miRNA and their interactions can be used as prognostic biomarkers or therapeutic targets for the treatment of HCC.</description><identifier>ISSN: 2073-4425</identifier><identifier>EISSN: 2073-4425</identifier><identifier>DOI: 10.3390/genes14010013</identifier><identifier>PMID: 36672755</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alcoholism ; Apoptosis ; Biomarkers ; Carcinoma, Hepatocellular - pathology ; Cell cycle ; Gene expression ; Hepatitis C ; Hepatocellular carcinoma ; Humans ; Information retrieval ; Liver cancer ; Liver diseases ; Liver Neoplasms - pathology ; MicroRNAs ; MicroRNAs - genetics ; MicroRNAs - metabolism ; miRNA ; Physiology ; RNA, Circular - genetics ; RNA, Circular - metabolism ; Signal transduction ; Statistical analysis ; Therapeutic targets ; Tumors</subject><ispartof>Genes, 2022-12, Vol.14 (1), p.13</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. 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| subjects | Alcoholism Apoptosis Biomarkers Carcinoma, Hepatocellular - pathology Cell cycle Gene expression Hepatitis C Hepatocellular carcinoma Humans Information retrieval Liver cancer Liver diseases Liver Neoplasms - pathology MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Physiology RNA, Circular - genetics RNA, Circular - metabolism Signal transduction Statistical analysis Therapeutic targets Tumors |
| title | The Role of miRNAs, circRNAs and Their Interactions in Development and Progression of Hepatocellular Carcinoma: An Insilico Approach |
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