Impaired synaptic transmission in dorsal dentate gyrus increases impulsive alcohol seeking

Both human and animal studies indicate that the dentate gyrus (DG) of the hippocampus is highly exploited by drug and alcohol abuse. Yet, it is poorly understood how DG dysfunction affects addiction-related behaviors. Here, we used an animal model of alcohol use disorder (AUD) in automated IntelliCa...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2023-02, Vol.48 (3), p.436-447
Hauptverfasser:	Nalberczak-Skóra, Maria, Beroun, Anna, Skonieczna, Edyta, Cały, Anna, Ziółkowska, Magdalena, Pagano, Roberto, Taheri, Pegah, Kalita, Katarzyna, Salamian, Ahmad, Radwanska, Kasia
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictions Alcohol Alcohol abuse Alcoholism - genetics Animal models Animals Dentate Gyrus Drug abuse Ethanol - pharmacology Glutamate receptors Humans Impulsivity Mice Motivation N-Methyl-D-aspartic acid receptors Potentiation Recurrence Reinforcement Synapses Synaptic Transmission α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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