Impaired synaptic transmission in dorsal dentate gyrus increases impulsive alcohol seeking
Both human and animal studies indicate that the dentate gyrus (DG) of the hippocampus is highly exploited by drug and alcohol abuse. Yet, it is poorly understood how DG dysfunction affects addiction-related behaviors. Here, we used an animal model of alcohol use disorder (AUD) in automated IntelliCa...
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| Veröffentlicht in: | Neuropsychopharmacology (New York, N.Y.) N.Y.), 2023-02, Vol.48 (3), p.436-447 |
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| creator | Nalberczak-Skóra, Maria Beroun, Anna Skonieczna, Edyta Cały, Anna Ziółkowska, Magdalena Pagano, Roberto Taheri, Pegah Kalita, Katarzyna Salamian, Ahmad Radwanska, Kasia |
| description | Both human and animal studies indicate that the dentate gyrus (DG) of the hippocampus is highly exploited by drug and alcohol abuse. Yet, it is poorly understood how DG dysfunction affects addiction-related behaviors. Here, we used an animal model of alcohol use disorder (AUD) in automated IntelliCages and performed local genetic manipulation to investigate how synaptic transmission in the dorsal DG (dDG) affects alcohol-related behaviors. We show that a cue light induces potentiation-like plasticity of dDG synapses in alcohol-naive mice. This process is impaired in mice trained to drink alcohol. Acamprosate (ACA), a drug that reduces alcohol relapse, rescues the impairment of dDG synaptic transmission in alcohol mice. A molecular manipulation that reduces dDG synaptic AMPAR and NMDAR levels increases impulsive alcohol seeking during cue relapse (CR) in alcohol mice but does not affect alcohol reward, motivation or craving. These findings suggest that hindered dDG synaptic transmission specifically underlies impulsive alcohol seeking induced by alcohol cues, a core symptom of AUD. |
| doi_str_mv | 10.1038/s41386-022-01464-5 |
| format | Article |
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Yet, it is poorly understood how DG dysfunction affects addiction-related behaviors. Here, we used an animal model of alcohol use disorder (AUD) in automated IntelliCages and performed local genetic manipulation to investigate how synaptic transmission in the dorsal DG (dDG) affects alcohol-related behaviors. We show that a cue light induces potentiation-like plasticity of dDG synapses in alcohol-naive mice. This process is impaired in mice trained to drink alcohol. Acamprosate (ACA), a drug that reduces alcohol relapse, rescues the impairment of dDG synaptic transmission in alcohol mice. A molecular manipulation that reduces dDG synaptic AMPAR and NMDAR levels increases impulsive alcohol seeking during cue relapse (CR) in alcohol mice but does not affect alcohol reward, motivation or craving. These findings suggest that hindered dDG synaptic transmission specifically underlies impulsive alcohol seeking induced by alcohol cues, a core symptom of AUD.</description><identifier>ISSN: 0893-133X</identifier><identifier>EISSN: 1740-634X</identifier><identifier>DOI: 10.1038/s41386-022-01464-5</identifier><identifier>PMID: 36182989</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Addictions ; Alcohol ; Alcohol abuse ; Alcoholism - genetics ; Animal models ; Animals ; Dentate Gyrus ; Drug abuse ; Ethanol - pharmacology ; Glutamate receptors ; Humans ; Impulsivity ; Mice ; Motivation ; N-Methyl-D-aspartic acid receptors ; Potentiation ; Recurrence ; Reinforcement ; Synapses ; Synaptic Transmission ; α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors</subject><ispartof>Neuropsychopharmacology (New York, N.Y.), 2023-02, Vol.48 (3), p.436-447</ispartof><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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These findings suggest that hindered dDG synaptic transmission specifically underlies impulsive alcohol seeking induced by alcohol cues, a core symptom of AUD.</description><subject>Addictions</subject><subject>Alcohol</subject><subject>Alcohol abuse</subject><subject>Alcoholism - genetics</subject><subject>Animal models</subject><subject>Animals</subject><subject>Dentate Gyrus</subject><subject>Drug abuse</subject><subject>Ethanol - pharmacology</subject><subject>Glutamate receptors</subject><subject>Humans</subject><subject>Impulsivity</subject><subject>Mice</subject><subject>Motivation</subject><subject>N-Methyl-D-aspartic acid receptors</subject><subject>Potentiation</subject><subject>Recurrence</subject><subject>Reinforcement</subject><subject>Synapses</subject><subject>Synaptic Transmission</subject><subject>α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors</subject><issn>0893-133X</issn><issn>1740-634X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkU2LFDEQhoMo7jj6BzxIgxcvrfnu5CLI4sfCgheFxUtIp6tns3Ynbap7Yf690VkX9VRF1VtFvfUQ8pzR14wK8wYlE0a3lPOWMqllqx6QHeskbbWQVw_JjhorWibE1Rl5gnhDKVOdNo_JmdDMcGvsjny7mBcfCwwNHpNf1hiatfiEc0SMOTUxNUMu6KdmgLT6FZrDsWxY66GAR6jZvGwTxlto_BTydZ4aBPge0-EpeTT6CeHZXdyTrx_efzn_1F5-_nhx_u6yDULTtQ2jDpap3mqm-7HvVdcHOujOjMEKy6wYrBQcKARdez6AN0rIjikWaoBR7Mnb095l62cYQr2z-MktJc6-HF320f3bSfHaHfKts0ZxVV-0J6_uFpT8YwNcXXUfYJp8gryh4x2nkkuhdZW-_E96k7eSqr2q0toyTmlXVfykCiUjFhjvj2HU_ULnTuhcRed-o3OqDr3428b9yB9W4idBdpc8</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Nalberczak-Skóra, Maria</creator><creator>Beroun, Anna</creator><creator>Skonieczna, Edyta</creator><creator>Cały, Anna</creator><creator>Ziółkowska, Magdalena</creator><creator>Pagano, Roberto</creator><creator>Taheri, Pegah</creator><creator>Kalita, Katarzyna</creator><creator>Salamian, Ahmad</creator><creator>Radwanska, Kasia</creator><general>Nature Publishing Group</general><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7445-6180</orcidid><orcidid>https://orcid.org/0000-0003-2841-9228</orcidid><orcidid>https://orcid.org/0000-0002-7687-4471</orcidid></search><sort><creationdate>20230201</creationdate><title>Impaired synaptic transmission in dorsal dentate gyrus increases impulsive alcohol seeking</title><author>Nalberczak-Skóra, Maria ; 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Yet, it is poorly understood how DG dysfunction affects addiction-related behaviors. Here, we used an animal model of alcohol use disorder (AUD) in automated IntelliCages and performed local genetic manipulation to investigate how synaptic transmission in the dorsal DG (dDG) affects alcohol-related behaviors. We show that a cue light induces potentiation-like plasticity of dDG synapses in alcohol-naive mice. This process is impaired in mice trained to drink alcohol. Acamprosate (ACA), a drug that reduces alcohol relapse, rescues the impairment of dDG synaptic transmission in alcohol mice. A molecular manipulation that reduces dDG synaptic AMPAR and NMDAR levels increases impulsive alcohol seeking during cue relapse (CR) in alcohol mice but does not affect alcohol reward, motivation or craving. 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| subjects | Addictions Alcohol Alcohol abuse Alcoholism - genetics Animal models Animals Dentate Gyrus Drug abuse Ethanol - pharmacology Glutamate receptors Humans Impulsivity Mice Motivation N-Methyl-D-aspartic acid receptors Potentiation Recurrence Reinforcement Synapses Synaptic Transmission α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors |
| title | Impaired synaptic transmission in dorsal dentate gyrus increases impulsive alcohol seeking |
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