Unstable Childhood, Adult Adversity, and Smoking Accelerate Biological Aging Among Middle-Age African Americans: Similar Findings for GrimAge and PoAm
Objectives: The recent biological clocks GrimAge and PoAm are robust predictors of morbidity and mortality. Little research, however, has investigated the factors that influence their ticking speed. No study has used multivariate analyses to examine whether childhood adversity, adult hardship, lifes...
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| Veröffentlicht in: | Journal of aging and health 2022-08, Vol.34 (4-5), p.487-498 |
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| container_title | Journal of aging and health |
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| creator | Simons, Ronald L. Ong, Mei Ling Lei, Man-Kit Klopack, Eric Berg, Mark Zhang, Yue Philibert, Robert Beach, Steven S. R. |
| description | Objectives: The recent biological clocks GrimAge and PoAm are robust predictors of morbidity and mortality. Little research, however, has investigated the factors that influence their ticking speed. No study has used multivariate analyses to examine whether childhood adversity, adult hardship, lifestyle practices, or some combination of these factors best explains acceleration of these indices. Methods: Using a sample of 506 middle-age African Americans, the present study investigated the extent to which childhood instability, adult adversity, and lifestyle predict accelerated GrimAge and PoAm. Results: The two clocks were highly correlated and the pattern of findings was very similar for the two measures. Childhood instability, adult financial hardship, and smoking were significant predictors of both clocks. Discussion: The findings support a life course perspective where both the long arm of childhood as well as later life conditions influence speed of aging. Similar results across the two clocks enhance confidence in the findings. |
| doi_str_mv | 10.1177/08982643211043668 |
| format | Article |
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Childhood instability, adult financial hardship, and smoking were significant predictors of both clocks. Discussion: The findings support a life course perspective where both the long arm of childhood as well as later life conditions influence speed of aging. 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R.</creatorcontrib><title>Unstable Childhood, Adult Adversity, and Smoking Accelerate Biological Aging Among Middle-Age African Americans: Similar Findings for GrimAge and PoAm</title><title>Journal of aging and health</title><addtitle>J Aging Health</addtitle><description>Objectives: The recent biological clocks GrimAge and PoAm are robust predictors of morbidity and mortality. Little research, however, has investigated the factors that influence their ticking speed. No study has used multivariate analyses to examine whether childhood adversity, adult hardship, lifestyle practices, or some combination of these factors best explains acceleration of these indices. Methods: Using a sample of 506 middle-age African Americans, the present study investigated the extent to which childhood instability, adult adversity, and lifestyle predict accelerated GrimAge and PoAm. Results: The two clocks were highly correlated and the pattern of findings was very similar for the two measures. Childhood instability, adult financial hardship, and smoking were significant predictors of both clocks. Discussion: The findings support a life course perspective where both the long arm of childhood as well as later life conditions influence speed of aging. Similar results across the two clocks enhance confidence in the findings.</description><subject>Aging</subject><subject>Black or African American</subject><subject>Childhood</subject><subject>Humans</subject><subject>Life Style</subject><subject>Middle age</subject><subject>Smoking</subject><subject>Smoking - epidemiology</subject><issn>0898-2643</issn><issn>1552-6887</issn><issn>1552-6887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctO3TAQhq2qqJzSPkA3laVuuiDUt9hOF5XSowKVqKhEWVtO7OSYOjHYCRIvwvPicCi9iY3t0f_NPzMeAN5gdICxEB-QrCThjBKMEaOcy2dghcuSFFxK8RysFr1YgF3wMqULhBDBCL8Au5SVpJSSrcDt-Zgm3XgL1xvnzSYEsw9rM_spn9c2Jjfd7EM9Gng2hJ9u7GHdttbbqCcLP7vgQ-9a7WHd32tDyOc3Z4y3Rd1bWHcxy2MW7P0jfYRnbnBeR3joRpNzEuxChEfRDQu_FPoe6uEV2Om0T_b1w70Hzg-__FgfFyenR1_X9UnRMs6nghgtpJHa0raxRueww6ZrMGak0YxqQQiilahKjBvecW4wp7Sl2LS8yiGme-DT1vdybgZrWjtOUXt1mdvR8UYF7dTfyug2qg_XqpLZk8hs8P7BIIar2aZJDS7lD_J6tGFOipSCMiorRDP67h_0IsxxzOMpIlAlUCkIyxTeUm0MKUXbPTaDkVq2rv7bes55--cUjxm_1pyBgy2QdG9_l33a8Q7TBbW9</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Simons, Ronald L.</creator><creator>Ong, Mei Ling</creator><creator>Lei, Man-Kit</creator><creator>Klopack, Eric</creator><creator>Berg, Mark</creator><creator>Zhang, Yue</creator><creator>Philibert, Robert</creator><creator>Beach, Steven S. 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R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of aging and health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simons, Ronald L.</au><au>Ong, Mei Ling</au><au>Lei, Man-Kit</au><au>Klopack, Eric</au><au>Berg, Mark</au><au>Zhang, Yue</au><au>Philibert, Robert</au><au>Beach, Steven S. 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| subjects | Aging Black or African American Childhood Humans Life Style Middle age Smoking Smoking - epidemiology |
| title | Unstable Childhood, Adult Adversity, and Smoking Accelerate Biological Aging Among Middle-Age African Americans: Similar Findings for GrimAge and PoAm |
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