In vitro magnetic hyperthermia properties of angle-shaped superparamagnetic iron oxide nanoparticles synthesized by a bromide-assisted polyol method
Currently, research on superparamagnetic iron oxide nanoparticles (SPIONs) for magnetic hyperthermia applications is steadily increasing. In this work, SPIONs were synthesized by the bromide-assisted polyol method and angle-shaped SPIONs were successfully generated with the optimized concentration o...
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| Veröffentlicht in: | RSC advances 2023-01, Vol.13 (5), p.2803-2810 |
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| creator | Kim, Hoonsub Im, Pyung Won Lee, Chaedong Hong, Hwichan Lee, Wooseung Koo, Changhyuk Park, Sang Yoon Im, Hyung-Jun Paek, Sun Ha Piao, Yuanzhe |
| description | Currently, research on superparamagnetic iron oxide nanoparticles (SPIONs) for magnetic hyperthermia applications is steadily increasing. In this work, SPIONs were synthesized by the bromide-assisted polyol method and angle-shaped SPIONs were successfully generated with the optimized concentration of bromide. The influence of bromide concentration on the shape of the generated SPIONs as well as the heating characteristics under an alternating magnetic field (AMF) was thoroughly investigated. At a concentration of 20 mg mL
of the angle-shaped SPIONs, the highest temperature curve up to 23 °C was observed under AMF with 140 Oe and 100 kHz for 10 min. With the biotoxicity assay, no significant cytotoxicity was observed in the normal fibroblast of HFB-141103 as well as tumor cells of U87MG and FSall treated with the angle-shaped SPIONs at a concentration below 100 μg mL
. However, significantly decreased cellular viability was observed in tumor cells of U87MG and FSall treated with 100 μg mL
of the angle-shaped SPIONs under AMF with 140 Oe and 100 kHz. Based on these results, it is thought that the angle-shaped SPIONs synthesized by the bromide-assisted polyol method will provide highly efficient magnetic hyperthermia therapy for cancers under biologically safe AMF with 140 Oe and 100 kHz. |
| doi_str_mv | 10.1039/d2ra07190h |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9850280</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2774894703</sourcerecordid><originalsourceid>FETCH-LOGICAL-c406t-9f26fb7ea792fe30b1658f0599a7077091bb9a15005d7a4ed0f20ef659321be23</originalsourceid><addsrcrecordid>eNpdkV9r1jAUxoMobszd-AEk4I0I1ZO0Sd7cCGP-2WAgiF6X0_b0bUab1KQd1s_hBzZz82Wam-Sc5_c8nHAYey7gjYDSvu1kRDDCwvCIHUuodCFB28cP3kfsNKVryEcrIbV4yo5KbZSuKn3Mfl16fuOWGPiEe0-La_mwzRSXgeLkkM8x3FaOEg89R78fqUgDztTxtGZlxogHp4vB8_DDdcQ9-pC13B2zNW0-Byb3M9uajSNvYpgyVmBKLi25O4dxCyOfaBlC94w96XFMdHp_n7BvHz98Pb8orj5_ujw_uyraCvRS2F7qvjGExsqeSmiEVrselLVowBiwomksCgWgOoMVddBLoF4rW0rRkCxP2Lu73HltJupa8kvEsZ6jmzBudUBX_6t4N9T7cFPbnQK5gxzw6j4ghu8rpaWeXGppHNFTWFMtjal2tjJQZvTlf-h1WKPP38uUtsoaValMvb6j2hhSitQfhhFQ3-67fi-_nP3Z90WGXzwc_4D-3W75G62dqig</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2769597545</pqid></control><display><type>article</type><title>In vitro magnetic hyperthermia properties of angle-shaped superparamagnetic iron oxide nanoparticles synthesized by a bromide-assisted polyol method</title><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Kim, Hoonsub ; Im, Pyung Won ; Lee, Chaedong ; Hong, Hwichan ; Lee, Wooseung ; Koo, Changhyuk ; Park, Sang Yoon ; Im, Hyung-Jun ; Paek, Sun Ha ; Piao, Yuanzhe</creator><creatorcontrib>Kim, Hoonsub ; Im, Pyung Won ; Lee, Chaedong ; Hong, Hwichan ; Lee, Wooseung ; Koo, Changhyuk ; Park, Sang Yoon ; Im, Hyung-Jun ; Paek, Sun Ha ; Piao, Yuanzhe</creatorcontrib><description>Currently, research on superparamagnetic iron oxide nanoparticles (SPIONs) for magnetic hyperthermia applications is steadily increasing. In this work, SPIONs were synthesized by the bromide-assisted polyol method and angle-shaped SPIONs were successfully generated with the optimized concentration of bromide. The influence of bromide concentration on the shape of the generated SPIONs as well as the heating characteristics under an alternating magnetic field (AMF) was thoroughly investigated. At a concentration of 20 mg mL
of the angle-shaped SPIONs, the highest temperature curve up to 23 °C was observed under AMF with 140 Oe and 100 kHz for 10 min. With the biotoxicity assay, no significant cytotoxicity was observed in the normal fibroblast of HFB-141103 as well as tumor cells of U87MG and FSall treated with the angle-shaped SPIONs at a concentration below 100 μg mL
. However, significantly decreased cellular viability was observed in tumor cells of U87MG and FSall treated with 100 μg mL
of the angle-shaped SPIONs under AMF with 140 Oe and 100 kHz. Based on these results, it is thought that the angle-shaped SPIONs synthesized by the bromide-assisted polyol method will provide highly efficient magnetic hyperthermia therapy for cancers under biologically safe AMF with 140 Oe and 100 kHz.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/d2ra07190h</identifier><identifier>PMID: 36756446</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Chemistry ; Fever ; Hyperthermia ; Iron oxides ; Magnetic properties ; Nanoparticles ; Synthesis ; Toxicity ; Tumors</subject><ispartof>RSC advances, 2023-01, Vol.13 (5), p.2803-2810</ispartof><rights>This journal is © The Royal Society of Chemistry.</rights><rights>Copyright Royal Society of Chemistry 2023</rights><rights>This journal is © The Royal Society of Chemistry 2023 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-9f26fb7ea792fe30b1658f0599a7077091bb9a15005d7a4ed0f20ef659321be23</citedby><cites>FETCH-LOGICAL-c406t-9f26fb7ea792fe30b1658f0599a7077091bb9a15005d7a4ed0f20ef659321be23</cites><orcidid>0000-0002-1505-236X ; 0000-0002-5530-3178</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850280/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9850280/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36756446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Hoonsub</creatorcontrib><creatorcontrib>Im, Pyung Won</creatorcontrib><creatorcontrib>Lee, Chaedong</creatorcontrib><creatorcontrib>Hong, Hwichan</creatorcontrib><creatorcontrib>Lee, Wooseung</creatorcontrib><creatorcontrib>Koo, Changhyuk</creatorcontrib><creatorcontrib>Park, Sang Yoon</creatorcontrib><creatorcontrib>Im, Hyung-Jun</creatorcontrib><creatorcontrib>Paek, Sun Ha</creatorcontrib><creatorcontrib>Piao, Yuanzhe</creatorcontrib><title>In vitro magnetic hyperthermia properties of angle-shaped superparamagnetic iron oxide nanoparticles synthesized by a bromide-assisted polyol method</title><title>RSC advances</title><addtitle>RSC Adv</addtitle><description>Currently, research on superparamagnetic iron oxide nanoparticles (SPIONs) for magnetic hyperthermia applications is steadily increasing. In this work, SPIONs were synthesized by the bromide-assisted polyol method and angle-shaped SPIONs were successfully generated with the optimized concentration of bromide. The influence of bromide concentration on the shape of the generated SPIONs as well as the heating characteristics under an alternating magnetic field (AMF) was thoroughly investigated. At a concentration of 20 mg mL
of the angle-shaped SPIONs, the highest temperature curve up to 23 °C was observed under AMF with 140 Oe and 100 kHz for 10 min. With the biotoxicity assay, no significant cytotoxicity was observed in the normal fibroblast of HFB-141103 as well as tumor cells of U87MG and FSall treated with the angle-shaped SPIONs at a concentration below 100 μg mL
. However, significantly decreased cellular viability was observed in tumor cells of U87MG and FSall treated with 100 μg mL
of the angle-shaped SPIONs under AMF with 140 Oe and 100 kHz. Based on these results, it is thought that the angle-shaped SPIONs synthesized by the bromide-assisted polyol method will provide highly efficient magnetic hyperthermia therapy for cancers under biologically safe AMF with 140 Oe and 100 kHz.</description><subject>Chemistry</subject><subject>Fever</subject><subject>Hyperthermia</subject><subject>Iron oxides</subject><subject>Magnetic properties</subject><subject>Nanoparticles</subject><subject>Synthesis</subject><subject>Toxicity</subject><subject>Tumors</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkV9r1jAUxoMobszd-AEk4I0I1ZO0Sd7cCGP-2WAgiF6X0_b0bUab1KQd1s_hBzZz82Wam-Sc5_c8nHAYey7gjYDSvu1kRDDCwvCIHUuodCFB28cP3kfsNKVryEcrIbV4yo5KbZSuKn3Mfl16fuOWGPiEe0-La_mwzRSXgeLkkM8x3FaOEg89R78fqUgDztTxtGZlxogHp4vB8_DDdcQ9-pC13B2zNW0-Byb3M9uajSNvYpgyVmBKLi25O4dxCyOfaBlC94w96XFMdHp_n7BvHz98Pb8orj5_ujw_uyraCvRS2F7qvjGExsqeSmiEVrselLVowBiwomksCgWgOoMVddBLoF4rW0rRkCxP2Lu73HltJupa8kvEsZ6jmzBudUBX_6t4N9T7cFPbnQK5gxzw6j4ghu8rpaWeXGppHNFTWFMtjal2tjJQZvTlf-h1WKPP38uUtsoaValMvb6j2hhSitQfhhFQ3-67fi-_nP3Z90WGXzwc_4D-3W75G62dqig</recordid><startdate>20230118</startdate><enddate>20230118</enddate><creator>Kim, Hoonsub</creator><creator>Im, Pyung Won</creator><creator>Lee, Chaedong</creator><creator>Hong, Hwichan</creator><creator>Lee, Wooseung</creator><creator>Koo, Changhyuk</creator><creator>Park, Sang Yoon</creator><creator>Im, Hyung-Jun</creator><creator>Paek, Sun Ha</creator><creator>Piao, Yuanzhe</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1505-236X</orcidid><orcidid>https://orcid.org/0000-0002-5530-3178</orcidid></search><sort><creationdate>20230118</creationdate><title>In vitro magnetic hyperthermia properties of angle-shaped superparamagnetic iron oxide nanoparticles synthesized by a bromide-assisted polyol method</title><author>Kim, Hoonsub ; Im, Pyung Won ; Lee, Chaedong ; Hong, Hwichan ; Lee, Wooseung ; Koo, Changhyuk ; Park, Sang Yoon ; Im, Hyung-Jun ; Paek, Sun Ha ; Piao, Yuanzhe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-9f26fb7ea792fe30b1658f0599a7077091bb9a15005d7a4ed0f20ef659321be23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Chemistry</topic><topic>Fever</topic><topic>Hyperthermia</topic><topic>Iron oxides</topic><topic>Magnetic properties</topic><topic>Nanoparticles</topic><topic>Synthesis</topic><topic>Toxicity</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hoonsub</creatorcontrib><creatorcontrib>Im, Pyung Won</creatorcontrib><creatorcontrib>Lee, Chaedong</creatorcontrib><creatorcontrib>Hong, Hwichan</creatorcontrib><creatorcontrib>Lee, Wooseung</creatorcontrib><creatorcontrib>Koo, Changhyuk</creatorcontrib><creatorcontrib>Park, Sang Yoon</creatorcontrib><creatorcontrib>Im, Hyung-Jun</creatorcontrib><creatorcontrib>Paek, Sun Ha</creatorcontrib><creatorcontrib>Piao, Yuanzhe</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Hoonsub</au><au>Im, Pyung Won</au><au>Lee, Chaedong</au><au>Hong, Hwichan</au><au>Lee, Wooseung</au><au>Koo, Changhyuk</au><au>Park, Sang Yoon</au><au>Im, Hyung-Jun</au><au>Paek, Sun Ha</au><au>Piao, Yuanzhe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro magnetic hyperthermia properties of angle-shaped superparamagnetic iron oxide nanoparticles synthesized by a bromide-assisted polyol method</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2023-01-18</date><risdate>2023</risdate><volume>13</volume><issue>5</issue><spage>2803</spage><epage>2810</epage><pages>2803-2810</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>Currently, research on superparamagnetic iron oxide nanoparticles (SPIONs) for magnetic hyperthermia applications is steadily increasing. In this work, SPIONs were synthesized by the bromide-assisted polyol method and angle-shaped SPIONs were successfully generated with the optimized concentration of bromide. The influence of bromide concentration on the shape of the generated SPIONs as well as the heating characteristics under an alternating magnetic field (AMF) was thoroughly investigated. At a concentration of 20 mg mL
of the angle-shaped SPIONs, the highest temperature curve up to 23 °C was observed under AMF with 140 Oe and 100 kHz for 10 min. With the biotoxicity assay, no significant cytotoxicity was observed in the normal fibroblast of HFB-141103 as well as tumor cells of U87MG and FSall treated with the angle-shaped SPIONs at a concentration below 100 μg mL
. However, significantly decreased cellular viability was observed in tumor cells of U87MG and FSall treated with 100 μg mL
of the angle-shaped SPIONs under AMF with 140 Oe and 100 kHz. Based on these results, it is thought that the angle-shaped SPIONs synthesized by the bromide-assisted polyol method will provide highly efficient magnetic hyperthermia therapy for cancers under biologically safe AMF with 140 Oe and 100 kHz.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>36756446</pmid><doi>10.1039/d2ra07190h</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1505-236X</orcidid><orcidid>https://orcid.org/0000-0002-5530-3178</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Chemistry Fever Hyperthermia Iron oxides Magnetic properties Nanoparticles Synthesis Toxicity Tumors |
| title | In vitro magnetic hyperthermia properties of angle-shaped superparamagnetic iron oxide nanoparticles synthesized by a bromide-assisted polyol method |
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