Drinking Water Sources along the Banks of Buriganga River of Bangladesh are Polluted and Possess Serious Health Risks: A Comprehensive In Vivo Analysis
Background. The river Buriganga, one of the major dumping zones of industrial wastes in Bangladesh, is responsible for contaminating the drinking water sources along its length. This study aimed to assess the water quality from these sources by monitoring the changes in hematological, biochemical, a...
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| creator | Ghosh, Banna Rahman, Muhammed Mahfuzur Saha, Tanoy Hossain, Md. Jamal Alam, Safaet Al-Aman, D. A. Anwar Kayser, Md. Shahidulla Islam, Md. Shariful Islam, Md. Kamrul Singh, Amit Ahmed, Tufael |
| description | Background. The river Buriganga, one of the major dumping zones of industrial wastes in Bangladesh, is responsible for contaminating the drinking water sources along its length. This study aimed to assess the water quality from these sources by monitoring the changes in hematological, biochemical, and histological parameters caused in healthy rats due to their consumption. Methods. Using ethylenediaminetetraacetic acid (EDTA) as an anticoagulant agent, hematological and biochemical analyses of Sprague–Dawley rat models were executed in this study. Following blood sampling, the rats were sacrificed, and the heart, lungs, kidneys, liver, and spleen were separated to carry out the histological analysis. Later, to perform the statistical analysis, SPSS, V.25.0 was utilized. Results. A significant rise (p |
| doi_str_mv | 10.1155/2023/3369163 |
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Jamal ; Alam, Safaet ; Al-Aman, D. A. Anwar ; Kayser, Md. Shahidulla ; Islam, Md. Shariful ; Islam, Md. Kamrul ; Singh, Amit ; Ahmed, Tufael</creator><contributor>Malik Muhammad, Akhtar ; Akhtar Malik Muhammad</contributor><creatorcontrib>Ghosh, Banna ; Rahman, Muhammed Mahfuzur ; Saha, Tanoy ; Hossain, Md. Jamal ; Alam, Safaet ; Al-Aman, D. A. Anwar ; Kayser, Md. Shahidulla ; Islam, Md. Shariful ; Islam, Md. Kamrul ; Singh, Amit ; Ahmed, Tufael ; Malik Muhammad, Akhtar ; Akhtar Malik Muhammad</creatorcontrib><description>Background. The river Buriganga, one of the major dumping zones of industrial wastes in Bangladesh, is responsible for contaminating the drinking water sources along its length. This study aimed to assess the water quality from these sources by monitoring the changes in hematological, biochemical, and histological parameters caused in healthy rats due to their consumption. Methods. Using ethylenediaminetetraacetic acid (EDTA) as an anticoagulant agent, hematological and biochemical analyses of Sprague–Dawley rat models were executed in this study. Following blood sampling, the rats were sacrificed, and the heart, lungs, kidneys, liver, and spleen were separated to carry out the histological analysis. Later, to perform the statistical analysis, SPSS, V.25.0 was utilized. Results. A significant rise (p<0.02) in body weight was recorded due to increased protein synthesis, inflammations; increased lymphocyte, white blood cell (WBC), and neutrophil count but hemoglobin (20.0 ± 1.39 g/dL vs. 15.25 ± 0.36 g/dL; p) and red blood cell (RBC) count ((6.24 ± 0.45) × 106/µL vs. (5.47 ± 0.34) × 106/µL)) decreased due to infections and hematopoietic stem cell poisoning by pathogens in water samples. Elevated (p<0.01) serum urea, creatinine, alanine, and aspartate aminotransferase levels indicated kidney malfunction and hepatic tissue necrosis. Histological analysis revealed gross lesions, internal hemorrhages in the brain; inflammations, granulomas, migrating macrophages in the spleen; fibrosis (resulting in hypo-perfusion), and collagen formation in cardiac muscles. Conclusions. The findings in this study provide comprehensive evidence, based on in vivo analysis, that the water bodies around the Buriganga river are likely to be contaminated with toxic chemicals and microbial entities making them unfit for human consumption.</description><identifier>ISSN: 1687-9805</identifier><identifier>EISSN: 1687-9813</identifier><identifier>DOI: 10.1155/2023/3369163</identifier><identifier>PMID: 36684485</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Acetic acid ; Alanine ; Animal models ; Animals ; Anticoagulants ; Aspartate ; Aspartate aminotransferase ; Bangladesh ; Banks (Finance) ; Biocompatibility ; Blood ; Body weight ; Cardiac muscle ; Cardiology ; Chemical oxygen demand ; Collagen ; Consumption ; Creatinine ; Drinking Water ; Dumping ; Edetic acid ; Effluents ; Erythrocytes ; Ethylenediaminetetraacetic acid ; Ethylenediaminetetraacetic acids ; Experiments ; Fibrosis ; Health aspects ; Health risks ; Heavy metals ; Hematology ; Hematopoietic stem cells ; Hemoglobin ; Hemorrhage ; Humans ; In vivo methods and tests ; Industrial wastes ; Inflammation ; Kidneys ; Laboratory animals ; Leukocytes (neutrophilic) ; Lymphocytes ; Macrophages ; Medical examination ; Microorganisms ; Muscles ; Protein biosynthesis ; Protein synthesis ; Quality assessment ; Rats ; Rats, Sprague-Dawley ; River banks ; Rivers ; Spleen ; Statistical analysis ; Stem cells ; Tissue analysis ; Urea ; Water analysis ; Water quality ; Water quality assessments ; Water sampling</subject><ispartof>Journal of environmental and public health, 2023, Vol.2023, p.3369163-7</ispartof><rights>Copyright © 2023 Banna Ghosh et al.</rights><rights>COPYRIGHT 2023 John Wiley & Sons, Inc.</rights><rights>Copyright © 2023 Banna Ghosh et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2023 Banna Ghosh et al. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3913-e9aa4939f7dae255ac3a57739c7d513ad15c2e6dfc1f652528349c11a2ba37cb3</citedby><cites>FETCH-LOGICAL-c3913-e9aa4939f7dae255ac3a57739c7d513ad15c2e6dfc1f652528349c11a2ba37cb3</cites><orcidid>0000-0002-0378-6542 ; 0000-0001-9706-207X ; 0000-0002-1831-2278</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9848808/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9848808/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,4012,27910,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36684485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Malik Muhammad, Akhtar</contributor><contributor>Akhtar Malik Muhammad</contributor><creatorcontrib>Ghosh, Banna</creatorcontrib><creatorcontrib>Rahman, Muhammed Mahfuzur</creatorcontrib><creatorcontrib>Saha, Tanoy</creatorcontrib><creatorcontrib>Hossain, Md. Jamal</creatorcontrib><creatorcontrib>Alam, Safaet</creatorcontrib><creatorcontrib>Al-Aman, D. A. Anwar</creatorcontrib><creatorcontrib>Kayser, Md. Shahidulla</creatorcontrib><creatorcontrib>Islam, Md. Shariful</creatorcontrib><creatorcontrib>Islam, Md. Kamrul</creatorcontrib><creatorcontrib>Singh, Amit</creatorcontrib><creatorcontrib>Ahmed, Tufael</creatorcontrib><title>Drinking Water Sources along the Banks of Buriganga River of Bangladesh are Polluted and Possess Serious Health Risks: A Comprehensive In Vivo Analysis</title><title>Journal of environmental and public health</title><addtitle>J Environ Public Health</addtitle><description>Background. The river Buriganga, one of the major dumping zones of industrial wastes in Bangladesh, is responsible for contaminating the drinking water sources along its length. This study aimed to assess the water quality from these sources by monitoring the changes in hematological, biochemical, and histological parameters caused in healthy rats due to their consumption. Methods. Using ethylenediaminetetraacetic acid (EDTA) as an anticoagulant agent, hematological and biochemical analyses of Sprague–Dawley rat models were executed in this study. Following blood sampling, the rats were sacrificed, and the heart, lungs, kidneys, liver, and spleen were separated to carry out the histological analysis. Later, to perform the statistical analysis, SPSS, V.25.0 was utilized. Results. A significant rise (p<0.02) in body weight was recorded due to increased protein synthesis, inflammations; increased lymphocyte, white blood cell (WBC), and neutrophil count but hemoglobin (20.0 ± 1.39 g/dL vs. 15.25 ± 0.36 g/dL; p) and red blood cell (RBC) count ((6.24 ± 0.45) × 106/µL vs. (5.47 ± 0.34) × 106/µL)) decreased due to infections and hematopoietic stem cell poisoning by pathogens in water samples. Elevated (p<0.01) serum urea, creatinine, alanine, and aspartate aminotransferase levels indicated kidney malfunction and hepatic tissue necrosis. Histological analysis revealed gross lesions, internal hemorrhages in the brain; inflammations, granulomas, migrating macrophages in the spleen; fibrosis (resulting in hypo-perfusion), and collagen formation in cardiac muscles. Conclusions. The findings in this study provide comprehensive evidence, based on in vivo analysis, that the water bodies around the Buriganga river are likely to be contaminated with toxic chemicals and microbial entities making them unfit for human consumption.</description><subject>Acetic acid</subject><subject>Alanine</subject><subject>Animal models</subject><subject>Animals</subject><subject>Anticoagulants</subject><subject>Aspartate</subject><subject>Aspartate aminotransferase</subject><subject>Bangladesh</subject><subject>Banks (Finance)</subject><subject>Biocompatibility</subject><subject>Blood</subject><subject>Body weight</subject><subject>Cardiac muscle</subject><subject>Cardiology</subject><subject>Chemical oxygen demand</subject><subject>Collagen</subject><subject>Consumption</subject><subject>Creatinine</subject><subject>Drinking Water</subject><subject>Dumping</subject><subject>Edetic acid</subject><subject>Effluents</subject><subject>Erythrocytes</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Ethylenediaminetetraacetic acids</subject><subject>Experiments</subject><subject>Fibrosis</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Heavy metals</subject><subject>Hematology</subject><subject>Hematopoietic stem cells</subject><subject>Hemoglobin</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>In vivo methods and tests</subject><subject>Industrial wastes</subject><subject>Inflammation</subject><subject>Kidneys</subject><subject>Laboratory animals</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphocytes</subject><subject>Macrophages</subject><subject>Medical examination</subject><subject>Microorganisms</subject><subject>Muscles</subject><subject>Protein biosynthesis</subject><subject>Protein synthesis</subject><subject>Quality assessment</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>River banks</subject><subject>Rivers</subject><subject>Spleen</subject><subject>Statistical analysis</subject><subject>Stem cells</subject><subject>Tissue analysis</subject><subject>Urea</subject><subject>Water analysis</subject><subject>Water quality</subject><subject>Water quality assessments</subject><subject>Water sampling</subject><issn>1687-9805</issn><issn>1687-9813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtvEzEURkeIipbCjjWyxBJCx_b4xaJSmgKtVAlEeSytG49nxs3EDvZMqv4S_i6Okoay6cr29fHR9f2K4hUu32PM2AkpCT2hlCvM6ZPiCHMpJkpi-nS_L9lh8Tylm7LkigryrDiknMuqkuyo-HMenV8436JfMNiIrsMYjU0I-pBrQ2fRGfhFQqFBZ2N0LfgW0De3zuimlI891DZ1CKJFX0Pfj4OtEfg6H1KyKaFrG10YE7qw0A9dfpsW6QOaollYrqLtrE_Zhi49-unWAU099HfJpRfFQQN9si9363Hx49PH77OLydWXz5ez6dXEUIXpxCqASlHViBosYQwMBSYEVUbUDFOoMTPE8roxuOGMMCJppQzGQOZAhZnT4-J0612N86WtjfVDhF6voltCvNMBnP7_xrtOt2GtlaykLGUWvNkJYvg92jTomzzC_IukieCCS8qE-ke10FvtfBOyzCxdMnoqaEVISSXP1LstZWIeXrTNvg9c6k3YehO23oWd8dcPe9_D9-lm4O0W6Jyv4dY9rvsL3V2yng</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Ghosh, Banna</creator><creator>Rahman, Muhammed Mahfuzur</creator><creator>Saha, Tanoy</creator><creator>Hossain, Md. 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Jamal ; Alam, Safaet ; Al-Aman, D. A. Anwar ; Kayser, Md. Shahidulla ; Islam, Md. Shariful ; Islam, Md. 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Jamal</au><au>Alam, Safaet</au><au>Al-Aman, D. A. Anwar</au><au>Kayser, Md. Shahidulla</au><au>Islam, Md. Shariful</au><au>Islam, Md. Kamrul</au><au>Singh, Amit</au><au>Ahmed, Tufael</au><au>Malik Muhammad, Akhtar</au><au>Akhtar Malik Muhammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drinking Water Sources along the Banks of Buriganga River of Bangladesh are Polluted and Possess Serious Health Risks: A Comprehensive In Vivo Analysis</atitle><jtitle>Journal of environmental and public health</jtitle><addtitle>J Environ Public Health</addtitle><date>2023</date><risdate>2023</risdate><volume>2023</volume><spage>3369163</spage><epage>7</epage><pages>3369163-7</pages><issn>1687-9805</issn><eissn>1687-9813</eissn><abstract>Background. The river Buriganga, one of the major dumping zones of industrial wastes in Bangladesh, is responsible for contaminating the drinking water sources along its length. This study aimed to assess the water quality from these sources by monitoring the changes in hematological, biochemical, and histological parameters caused in healthy rats due to their consumption. Methods. Using ethylenediaminetetraacetic acid (EDTA) as an anticoagulant agent, hematological and biochemical analyses of Sprague–Dawley rat models were executed in this study. Following blood sampling, the rats were sacrificed, and the heart, lungs, kidneys, liver, and spleen were separated to carry out the histological analysis. Later, to perform the statistical analysis, SPSS, V.25.0 was utilized. Results. A significant rise (p<0.02) in body weight was recorded due to increased protein synthesis, inflammations; increased lymphocyte, white blood cell (WBC), and neutrophil count but hemoglobin (20.0 ± 1.39 g/dL vs. 15.25 ± 0.36 g/dL; p) and red blood cell (RBC) count ((6.24 ± 0.45) × 106/µL vs. (5.47 ± 0.34) × 106/µL)) decreased due to infections and hematopoietic stem cell poisoning by pathogens in water samples. Elevated (p<0.01) serum urea, creatinine, alanine, and aspartate aminotransferase levels indicated kidney malfunction and hepatic tissue necrosis. Histological analysis revealed gross lesions, internal hemorrhages in the brain; inflammations, granulomas, migrating macrophages in the spleen; fibrosis (resulting in hypo-perfusion), and collagen formation in cardiac muscles. Conclusions. The findings in this study provide comprehensive evidence, based on in vivo analysis, that the water bodies around the Buriganga river are likely to be contaminated with toxic chemicals and microbial entities making them unfit for human consumption.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>36684485</pmid><doi>10.1155/2023/3369163</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0378-6542</orcidid><orcidid>https://orcid.org/0000-0001-9706-207X</orcidid><orcidid>https://orcid.org/0000-0002-1831-2278</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of environmental and public health, 2023, Vol.2023, p.3369163-7 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9848808 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Wiley-Blackwell Open Access Titles; PubMed Central; Alma/SFX Local Collection |
| subjects | Acetic acid Alanine Animal models Animals Anticoagulants Aspartate Aspartate aminotransferase Bangladesh Banks (Finance) Biocompatibility Blood Body weight Cardiac muscle Cardiology Chemical oxygen demand Collagen Consumption Creatinine Drinking Water Dumping Edetic acid Effluents Erythrocytes Ethylenediaminetetraacetic acid Ethylenediaminetetraacetic acids Experiments Fibrosis Health aspects Health risks Heavy metals Hematology Hematopoietic stem cells Hemoglobin Hemorrhage Humans In vivo methods and tests Industrial wastes Inflammation Kidneys Laboratory animals Leukocytes (neutrophilic) Lymphocytes Macrophages Medical examination Microorganisms Muscles Protein biosynthesis Protein synthesis Quality assessment Rats Rats, Sprague-Dawley River banks Rivers Spleen Statistical analysis Stem cells Tissue analysis Urea Water analysis Water quality Water quality assessments Water sampling |
| title | Drinking Water Sources along the Banks of Buriganga River of Bangladesh are Polluted and Possess Serious Health Risks: A Comprehensive In Vivo Analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T14%3A33%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Drinking%20Water%20Sources%20along%20the%20Banks%20of%20Buriganga%20River%20of%20Bangladesh%20are%20Polluted%20and%20Possess%20Serious%20Health%20Risks:%20A%20Comprehensive%20In%20Vivo%20Analysis&rft.jtitle=Journal%20of%20environmental%20and%20public%20health&rft.au=Ghosh,%20Banna&rft.date=2023&rft.volume=2023&rft.spage=3369163&rft.epage=7&rft.pages=3369163-7&rft.issn=1687-9805&rft.eissn=1687-9813&rft_id=info:doi/10.1155/2023/3369163&rft_dat=%3Cgale_pubme%3EA734220386%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2767683579&rft_id=info:pmid/36684485&rft_galeid=A734220386&rfr_iscdi=true |