Hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis
Cirrhosis is an emerging major cause of the development of hepatocellular carcinoma (HCC), but in non-alcoholic fatty liver disease (NAFLD), up to 50% of patients with HCC had no clinical or histological evidence of cirrhosis. It is currently challenging to propose general recommendations for screen...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2023-01, Vol.29 (2), p.343-356 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Tovo, Cristiane Valle de Mattos, Angelo Zambam Coral, Gabriela Perdomo Sartori, Giovana D P Nogueira, Livia Villela Both, Gustavo Tovo Villela-Nogueira, Cristiane A de Mattos, Angelo A |
| description | Cirrhosis is an emerging major cause of the development of hepatocellular carcinoma (HCC), but in non-alcoholic fatty liver disease (NAFLD), up to 50% of patients with HCC had no clinical or histological evidence of cirrhosis. It is currently challenging to propose general recommendations for screening patients with NAFLD without cirrhosis, and each patient should be evaluated on a case-by-case basis based on the profile of specific risk factors identified. For HCC screening in NAFLD, a valid precision-based screening is needed. Currently, when evaluating this population of patients, the use of non-invasive methods can guide the selection of those who should undergo a screening and surveillance program. Hence, the objective of the present study is to review the epidemiology, the pathophysiology, the histopathological aspects, the current recommendations, and novel perspectives in the surveillance of non-cirrhotic NAFLD-related HCC. |
| doi_str_mv | 10.3748/wjg.v29.i2.343 |
| format | Article |
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It is currently challenging to propose general recommendations for screening patients with NAFLD without cirrhosis, and each patient should be evaluated on a case-by-case basis based on the profile of specific risk factors identified. For HCC screening in NAFLD, a valid precision-based screening is needed. Currently, when evaluating this population of patients, the use of non-invasive methods can guide the selection of those who should undergo a screening and surveillance program. Hence, the objective of the present study is to review the epidemiology, the pathophysiology, the histopathological aspects, the current recommendations, and novel perspectives in the surveillance of non-cirrhotic NAFLD-related HCC.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v29.i2.343</identifier><identifier>PMID: 36687125</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - epidemiology ; Carcinoma, Hepatocellular - etiology ; Fibrosis ; Humans ; Liver Cirrhosis - complications ; Liver Cirrhosis - diagnosis ; Liver Cirrhosis - epidemiology ; Liver Neoplasms - diagnosis ; Liver Neoplasms - epidemiology ; Liver Neoplasms - etiology ; Minireviews ; Non-alcoholic Fatty Liver Disease - complications ; Non-alcoholic Fatty Liver Disease - diagnosis ; Non-alcoholic Fatty Liver Disease - epidemiology ; Risk Factors</subject><ispartof>World journal of gastroenterology : WJG, 2023-01, Vol.29 (2), p.343-356</ispartof><rights>The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.</rights><rights>The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. 2023</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c320t-f84cc406d0f2e4c474b9b7d4842f91dee8ce6dd4f9b51cba50e75dc9717505ae3</citedby><cites>FETCH-LOGICAL-c320t-f84cc406d0f2e4c474b9b7d4842f91dee8ce6dd4f9b51cba50e75dc9717505ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846942/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9846942/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36687125$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tovo, Cristiane Valle</creatorcontrib><creatorcontrib>de Mattos, Angelo Zambam</creatorcontrib><creatorcontrib>Coral, Gabriela Perdomo</creatorcontrib><creatorcontrib>Sartori, Giovana D P</creatorcontrib><creatorcontrib>Nogueira, Livia Villela</creatorcontrib><creatorcontrib>Both, Gustavo Tovo</creatorcontrib><creatorcontrib>Villela-Nogueira, Cristiane A</creatorcontrib><creatorcontrib>de Mattos, Angelo A</creatorcontrib><title>Hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis</title><title>World journal of gastroenterology : WJG</title><addtitle>World J Gastroenterol</addtitle><description>Cirrhosis is an emerging major cause of the development of hepatocellular carcinoma (HCC), but in non-alcoholic fatty liver disease (NAFLD), up to 50% of patients with HCC had no clinical or histological evidence of cirrhosis. It is currently challenging to propose general recommendations for screening patients with NAFLD without cirrhosis, and each patient should be evaluated on a case-by-case basis based on the profile of specific risk factors identified. For HCC screening in NAFLD, a valid precision-based screening is needed. Currently, when evaluating this population of patients, the use of non-invasive methods can guide the selection of those who should undergo a screening and surveillance program. Hence, the objective of the present study is to review the epidemiology, the pathophysiology, the histopathological aspects, the current recommendations, and novel perspectives in the surveillance of non-cirrhotic NAFLD-related HCC.</description><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - epidemiology</subject><subject>Carcinoma, Hepatocellular - etiology</subject><subject>Fibrosis</subject><subject>Humans</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Cirrhosis - diagnosis</subject><subject>Liver Cirrhosis - epidemiology</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - epidemiology</subject><subject>Liver Neoplasms - etiology</subject><subject>Minireviews</subject><subject>Non-alcoholic Fatty Liver Disease - complications</subject><subject>Non-alcoholic Fatty Liver Disease - diagnosis</subject><subject>Non-alcoholic Fatty Liver Disease - epidemiology</subject><subject>Risk Factors</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkT1PwzAQhi0EoqWwMqKMLAn-SmwvSKgCiqjEArPlOE7jKomL7bTi35OqBcF0wz333ukeAK4RzAij_G63XmVbLDKLM0LJCZhijESKOYWnYIogZKkgmE3ARQhrCDEhOT4HE1IUnCGcT8HrwmxUdNq07dAqn2jlte1dpxLbJ73rU9Vq17jW6iREM5LNnrfRhmRnY-OGmGjrfeOCDZfgrFZtMFfHOgMfT4_v80W6fHt-mT8sU00wjGnNqdYUFhWssaGaMlqKklWUU1wLVBnDtSmqitaizJEuVQ4NyystGGI5zJUhM3B_yN0MZWcqbfroVSs33nbKf0mnrPzf6W0jV24rBaeFoHgMuD0GePc5mBBlZ8P-Bao3bggSs4JzhBksRjQ7oNq7ELypf9cgKPcG5GhAjgakxXI0MA7c_D3uF_95OfkGeoGGdQ</recordid><startdate>20230114</startdate><enddate>20230114</enddate><creator>Tovo, Cristiane Valle</creator><creator>de Mattos, Angelo Zambam</creator><creator>Coral, Gabriela Perdomo</creator><creator>Sartori, Giovana D P</creator><creator>Nogueira, Livia Villela</creator><creator>Both, Gustavo Tovo</creator><creator>Villela-Nogueira, Cristiane A</creator><creator>de Mattos, Angelo A</creator><general>Baishideng Publishing Group Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230114</creationdate><title>Hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis</title><author>Tovo, Cristiane Valle ; 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It is currently challenging to propose general recommendations for screening patients with NAFLD without cirrhosis, and each patient should be evaluated on a case-by-case basis based on the profile of specific risk factors identified. For HCC screening in NAFLD, a valid precision-based screening is needed. Currently, when evaluating this population of patients, the use of non-invasive methods can guide the selection of those who should undergo a screening and surveillance program. Hence, the objective of the present study is to review the epidemiology, the pathophysiology, the histopathological aspects, the current recommendations, and novel perspectives in the surveillance of non-cirrhotic NAFLD-related HCC.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>36687125</pmid><doi>10.3748/wjg.v29.i2.343</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - etiology Fibrosis Humans Liver Cirrhosis - complications Liver Cirrhosis - diagnosis Liver Cirrhosis - epidemiology Liver Neoplasms - diagnosis Liver Neoplasms - epidemiology Liver Neoplasms - etiology Minireviews Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - diagnosis Non-alcoholic Fatty Liver Disease - epidemiology Risk Factors |
| title | Hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis |
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