Interplay between C1-inhibitor and group IIA secreted phospholipase A2 impairs their respective function

High levels of human group IIA secreted phospholipase A 2 (hGIIA) have been associated with various inflammatory disease conditions. We have recently shown that hGIIA activity and concentration are increased in the plasma of patients with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-...

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Veröffentlicht in:	Immunologic research 2023-02, Vol.71 (1), p.70-82
Hauptverfasser:	Ferrara, Anne Lise, Bova, Maria, Petraroli, Angelica, Marasco, Daniela, Payré, Christine, Fortuna, Sara, Palestra, Francesco, Ciardi, Renato, Marone, Gianni, Spadaro, Giuseppe, Lambeau, Gérard, Loffredo, Stefania
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergology Angioedema Antibiotics Biomedical and Life Sciences Biomedicine Blood & organ donations Cell activation E coli Edema Enzymatic activity Enzymes Experiments Fatty acids Immune system Immunology Inflammatory diseases Inhibitors Interleukin 6 Internal Medicine Leukocytes (mononuclear) Life Sciences Medicine/Public Health Molecular docking Original Original Article Peripheral blood mononuclear cells Phospholipase Phospholipase A2 Plasma Proteins Reagents Tumor necrosis factor-TNF Tumor necrosis factor-α
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