Association between PaO2/FiO2 ratio and thrombotic events in COVID-19 patients
PaO 2 /FiO 2 (P/F ratio) is considered a marker of hypoxia/hypoxemia and mortality. Several prothrombotic changes are associated with the decrease of P/F ratio. The role of P/F ratio in patients with arterial and venous thrombosis remains unclear. The aim of this study was to assess in patients with...
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| Veröffentlicht in: | Internal and emergency medicine 2023-04, Vol.18 (3), p.889-895 |
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| creator | Loffredo, Lorenzo Pignatelli, Pasquale Pirro, Matteo Ceccarelli, Giancarlo Oliva, Alessandra Maggio, Enrico Cancelli, Francesca D’Ardes, Damiano Amitrano, Maria Zicari, Anna Maria Cinicola, Bianca Laura Taliani, Gloria Cangemi, Roberto Lichtner, Miriam Falcone, Marco Orlando, Federica Pugliese, Francesco Venditti, Mario Mastroianni, Claudio Maria Violi, Francesco |
| description | PaO
2
/FiO
2
(P/F ratio) is considered a marker of hypoxia/hypoxemia and mortality. Several prothrombotic changes are associated with the decrease of P/F ratio. The role of P/F ratio in patients with arterial and venous thrombosis remains unclear. The aim of this study was to assess in patients with coronavirus disease 2019 (COVID-19), the association between P/F ratio and arterial/venous thrombosis. One thousand and four hundred and six COVID-19 patients were recruited; 289 (21%) patients had P/F ratio |
| doi_str_mv | 10.1007/s11739-023-03196-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9845099</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2797454217</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-4130cee0e6e064eef72814a21f68e5c86d83488cc16ef2a6e35f887034a2effc3</originalsourceid><addsrcrecordid>eNp9kU9vVCEUxYnR2Dr6BVyRuHFDywUefzYmzWhrk8ZxoW4Jw9zX0szACG868dvLOI1GF6644fzOgZtDyGvgZ8C5OW8ARjrGhWRcgtNs_4ScgjOcOan10z5bYRlXypyQF63dcz4MGsxzctLloVvglHy6aK3EFKZUMl3itEfM9HNYiPPLtBC0HgQa8opOd7VslmVKkeID5qnRlOl88e36PQNHt507XL4kz8awbvjq8ZyRr5cfvsw_spvF1fX84oZFNcDEFEgeETlq5FohjkZYUEHAqC0O0eqVlcraGEHjKIJGOYzWGi47g-MY5Yy8O-Zud8sNrmJ_u4a139a0CfWHLyH5v5Wc7vxtefDOqoE71wPePgbU8n2HbfKb1CKu1yFj2TUvjNYGHFjo6Jt_0Puyq7mv1yln1KBE72FGxJGKtbRWcfz9GeD-UJc_1uV7Xf5XXX7fTfJoah3Ot1j_RP_H9RMK45Zh</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2797454217</pqid></control><display><type>article</type><title>Association between PaO2/FiO2 ratio and thrombotic events in COVID-19 patients</title><source>SpringerLink Journals - AutoHoldings</source><creator>Loffredo, Lorenzo ; Pignatelli, Pasquale ; Pirro, Matteo ; Ceccarelli, Giancarlo ; Oliva, Alessandra ; Maggio, Enrico ; Cancelli, Francesca ; D’Ardes, Damiano ; Amitrano, Maria ; Zicari, Anna Maria ; Cinicola, Bianca Laura ; Taliani, Gloria ; Cangemi, Roberto ; Lichtner, Miriam ; Falcone, Marco ; Orlando, Federica ; Pugliese, Francesco ; Venditti, Mario ; Mastroianni, Claudio Maria ; Violi, Francesco</creator><creatorcontrib>Loffredo, Lorenzo ; Pignatelli, Pasquale ; Pirro, Matteo ; Ceccarelli, Giancarlo ; Oliva, Alessandra ; Maggio, Enrico ; Cancelli, Francesca ; D’Ardes, Damiano ; Amitrano, Maria ; Zicari, Anna Maria ; Cinicola, Bianca Laura ; Taliani, Gloria ; Cangemi, Roberto ; Lichtner, Miriam ; Falcone, Marco ; Orlando, Federica ; Pugliese, Francesco ; Venditti, Mario ; Mastroianni, Claudio Maria ; Violi, Francesco ; COVID-Group</creatorcontrib><description>PaO
2
/FiO
2
(P/F ratio) is considered a marker of hypoxia/hypoxemia and mortality. Several prothrombotic changes are associated with the decrease of P/F ratio. The role of P/F ratio in patients with arterial and venous thrombosis remains unclear. The aim of this study was to assess in patients with coronavirus disease 2019 (COVID-19), the association between P/F ratio and arterial/venous thrombosis. One thousand and four hundred and six COVID-19 patients were recruited; 289 (21%) patients had P/F ratio < 200 and 1117 (79%) ≥ 200. Compared to the patients with P/F ratio ≥ 200, those with P/F ratio < 200 were older and with higher levels of glycemia, D–dimer and lower levels of albumin. Multiple linear regression analysis showed that albumin (standardized coefficient
β
: 0.156; SE: 0.001;
p
= 0.0001) and D–dimer (standardized coefficient
β
: -0.135; SE: 0.0001;
p
= 0.0001) were associated with P/F ratio. During the hospitalization 159 patients were transferred in intensive care unit (ICU), 253 patients died, 156 patients had arterial or venous thrombotic events. A bivariate logistic analysis was performed to analyze the predictors of thrombosis in COVID-19 patients; P/F ratio < 200 (Odds Ratio: [OR] 1.718, 95% Confidence Interval [CI] 1.085–2.718,
p
= 0.021), albumin (OR 1.693, 95% CI 1.055–2.716,
p
= 0.029), D-dimer (OR 3.469, 95% CI 2.110–5.703,
p
< 0.0001), coronary artery disease (CAD) (OR 1.800, 95% CI 1.086–2.984,
p
= 0.023) and heart failure (OR 2.410 95% CI 1.385–4.193,
p
= 0.002) independently predicted thrombotic events in this population. This study suggests that the P/F ratio is associated with thrombotic events by promoting a hypercoagulation state in patients hospitalized for COVID-19.</description><identifier>ISSN: 1828-0447</identifier><identifier>EISSN: 1970-9366</identifier><identifier>DOI: 10.1007/s11739-023-03196-w</identifier><identifier>PMID: 36650311</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Albumin ; Blood glucose ; Cardiovascular disease ; Congestive heart failure ; Coronary artery disease ; Coronaviruses ; COVID-19 ; COVID-19 : diagnosis ; EM - Original ; Heart diseases ; Hypoxemia ; Hypoxia ; Internal Medicine ; management and prognosis ; Medicine ; Medicine & Public Health ; Population studies ; Thrombosis</subject><ispartof>Internal and emergency medicine, 2023-04, Vol.18 (3), p.889-895</ispartof><rights>The Author(s) 2023</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-4130cee0e6e064eef72814a21f68e5c86d83488cc16ef2a6e35f887034a2effc3</citedby><cites>FETCH-LOGICAL-c451t-4130cee0e6e064eef72814a21f68e5c86d83488cc16ef2a6e35f887034a2effc3</cites><orcidid>0000-0002-6542-6235</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11739-023-03196-w$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11739-023-03196-w$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Loffredo, Lorenzo</creatorcontrib><creatorcontrib>Pignatelli, Pasquale</creatorcontrib><creatorcontrib>Pirro, Matteo</creatorcontrib><creatorcontrib>Ceccarelli, Giancarlo</creatorcontrib><creatorcontrib>Oliva, Alessandra</creatorcontrib><creatorcontrib>Maggio, Enrico</creatorcontrib><creatorcontrib>Cancelli, Francesca</creatorcontrib><creatorcontrib>D’Ardes, Damiano</creatorcontrib><creatorcontrib>Amitrano, Maria</creatorcontrib><creatorcontrib>Zicari, Anna Maria</creatorcontrib><creatorcontrib>Cinicola, Bianca Laura</creatorcontrib><creatorcontrib>Taliani, Gloria</creatorcontrib><creatorcontrib>Cangemi, Roberto</creatorcontrib><creatorcontrib>Lichtner, Miriam</creatorcontrib><creatorcontrib>Falcone, Marco</creatorcontrib><creatorcontrib>Orlando, Federica</creatorcontrib><creatorcontrib>Pugliese, Francesco</creatorcontrib><creatorcontrib>Venditti, Mario</creatorcontrib><creatorcontrib>Mastroianni, Claudio Maria</creatorcontrib><creatorcontrib>Violi, Francesco</creatorcontrib><creatorcontrib>COVID-Group</creatorcontrib><title>Association between PaO2/FiO2 ratio and thrombotic events in COVID-19 patients</title><title>Internal and emergency medicine</title><addtitle>Intern Emerg Med</addtitle><description>PaO
2
/FiO
2
(P/F ratio) is considered a marker of hypoxia/hypoxemia and mortality. Several prothrombotic changes are associated with the decrease of P/F ratio. The role of P/F ratio in patients with arterial and venous thrombosis remains unclear. The aim of this study was to assess in patients with coronavirus disease 2019 (COVID-19), the association between P/F ratio and arterial/venous thrombosis. One thousand and four hundred and six COVID-19 patients were recruited; 289 (21%) patients had P/F ratio < 200 and 1117 (79%) ≥ 200. Compared to the patients with P/F ratio ≥ 200, those with P/F ratio < 200 were older and with higher levels of glycemia, D–dimer and lower levels of albumin. Multiple linear regression analysis showed that albumin (standardized coefficient
β
: 0.156; SE: 0.001;
p
= 0.0001) and D–dimer (standardized coefficient
β
: -0.135; SE: 0.0001;
p
= 0.0001) were associated with P/F ratio. During the hospitalization 159 patients were transferred in intensive care unit (ICU), 253 patients died, 156 patients had arterial or venous thrombotic events. A bivariate logistic analysis was performed to analyze the predictors of thrombosis in COVID-19 patients; P/F ratio < 200 (Odds Ratio: [OR] 1.718, 95% Confidence Interval [CI] 1.085–2.718,
p
= 0.021), albumin (OR 1.693, 95% CI 1.055–2.716,
p
= 0.029), D-dimer (OR 3.469, 95% CI 2.110–5.703,
p
< 0.0001), coronary artery disease (CAD) (OR 1.800, 95% CI 1.086–2.984,
p
= 0.023) and heart failure (OR 2.410 95% CI 1.385–4.193,
p
= 0.002) independently predicted thrombotic events in this population. This study suggests that the P/F ratio is associated with thrombotic events by promoting a hypercoagulation state in patients hospitalized for COVID-19.</description><subject>Albumin</subject><subject>Blood glucose</subject><subject>Cardiovascular disease</subject><subject>Congestive heart failure</subject><subject>Coronary artery disease</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 : diagnosis</subject><subject>EM - Original</subject><subject>Heart diseases</subject><subject>Hypoxemia</subject><subject>Hypoxia</subject><subject>Internal Medicine</subject><subject>management and prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Population studies</subject><subject>Thrombosis</subject><issn>1828-0447</issn><issn>1970-9366</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU9vVCEUxYnR2Dr6BVyRuHFDywUefzYmzWhrk8ZxoW4Jw9zX0szACG868dvLOI1GF6644fzOgZtDyGvgZ8C5OW8ARjrGhWRcgtNs_4ScgjOcOan10z5bYRlXypyQF63dcz4MGsxzctLloVvglHy6aK3EFKZUMl3itEfM9HNYiPPLtBC0HgQa8opOd7VslmVKkeID5qnRlOl88e36PQNHt507XL4kz8awbvjq8ZyRr5cfvsw_spvF1fX84oZFNcDEFEgeETlq5FohjkZYUEHAqC0O0eqVlcraGEHjKIJGOYzWGi47g-MY5Yy8O-Zud8sNrmJ_u4a139a0CfWHLyH5v5Wc7vxtefDOqoE71wPePgbU8n2HbfKb1CKu1yFj2TUvjNYGHFjo6Jt_0Puyq7mv1yln1KBE72FGxJGKtbRWcfz9GeD-UJc_1uV7Xf5XXX7fTfJoah3Ot1j_RP_H9RMK45Zh</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Loffredo, Lorenzo</creator><creator>Pignatelli, Pasquale</creator><creator>Pirro, Matteo</creator><creator>Ceccarelli, Giancarlo</creator><creator>Oliva, Alessandra</creator><creator>Maggio, Enrico</creator><creator>Cancelli, Francesca</creator><creator>D’Ardes, Damiano</creator><creator>Amitrano, Maria</creator><creator>Zicari, Anna Maria</creator><creator>Cinicola, Bianca Laura</creator><creator>Taliani, Gloria</creator><creator>Cangemi, Roberto</creator><creator>Lichtner, Miriam</creator><creator>Falcone, Marco</creator><creator>Orlando, Federica</creator><creator>Pugliese, Francesco</creator><creator>Venditti, Mario</creator><creator>Mastroianni, Claudio Maria</creator><creator>Violi, Francesco</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6542-6235</orcidid></search><sort><creationdate>20230401</creationdate><title>Association between PaO2/FiO2 ratio and thrombotic events in COVID-19 patients</title><author>Loffredo, Lorenzo ; Pignatelli, Pasquale ; Pirro, Matteo ; Ceccarelli, Giancarlo ; Oliva, Alessandra ; Maggio, Enrico ; Cancelli, Francesca ; D’Ardes, Damiano ; Amitrano, Maria ; Zicari, Anna Maria ; Cinicola, Bianca Laura ; Taliani, Gloria ; Cangemi, Roberto ; Lichtner, Miriam ; Falcone, Marco ; Orlando, Federica ; Pugliese, Francesco ; Venditti, Mario ; Mastroianni, Claudio Maria ; Violi, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-4130cee0e6e064eef72814a21f68e5c86d83488cc16ef2a6e35f887034a2effc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Albumin</topic><topic>Blood glucose</topic><topic>Cardiovascular disease</topic><topic>Congestive heart failure</topic><topic>Coronary artery disease</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 : diagnosis</topic><topic>EM - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal and emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Loffredo, Lorenzo</au><au>Pignatelli, Pasquale</au><au>Pirro, Matteo</au><au>Ceccarelli, Giancarlo</au><au>Oliva, Alessandra</au><au>Maggio, Enrico</au><au>Cancelli, Francesca</au><au>D’Ardes, Damiano</au><au>Amitrano, Maria</au><au>Zicari, Anna Maria</au><au>Cinicola, Bianca Laura</au><au>Taliani, Gloria</au><au>Cangemi, Roberto</au><au>Lichtner, Miriam</au><au>Falcone, Marco</au><au>Orlando, Federica</au><au>Pugliese, Francesco</au><au>Venditti, Mario</au><au>Mastroianni, Claudio Maria</au><au>Violi, Francesco</au><aucorp>COVID-Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between PaO2/FiO2 ratio and thrombotic events in COVID-19 patients</atitle><jtitle>Internal and emergency medicine</jtitle><stitle>Intern Emerg Med</stitle><date>2023-04-01</date><risdate>2023</risdate><volume>18</volume><issue>3</issue><spage>889</spage><epage>895</epage><pages>889-895</pages><issn>1828-0447</issn><eissn>1970-9366</eissn><abstract>PaO
2
/FiO
2
(P/F ratio) is considered a marker of hypoxia/hypoxemia and mortality. Several prothrombotic changes are associated with the decrease of P/F ratio. The role of P/F ratio in patients with arterial and venous thrombosis remains unclear. The aim of this study was to assess in patients with coronavirus disease 2019 (COVID-19), the association between P/F ratio and arterial/venous thrombosis. One thousand and four hundred and six COVID-19 patients were recruited; 289 (21%) patients had P/F ratio < 200 and 1117 (79%) ≥ 200. Compared to the patients with P/F ratio ≥ 200, those with P/F ratio < 200 were older and with higher levels of glycemia, D–dimer and lower levels of albumin. Multiple linear regression analysis showed that albumin (standardized coefficient
β
: 0.156; SE: 0.001;
p
= 0.0001) and D–dimer (standardized coefficient
β
: -0.135; SE: 0.0001;
p
= 0.0001) were associated with P/F ratio. During the hospitalization 159 patients were transferred in intensive care unit (ICU), 253 patients died, 156 patients had arterial or venous thrombotic events. A bivariate logistic analysis was performed to analyze the predictors of thrombosis in COVID-19 patients; P/F ratio < 200 (Odds Ratio: [OR] 1.718, 95% Confidence Interval [CI] 1.085–2.718,
p
= 0.021), albumin (OR 1.693, 95% CI 1.055–2.716,
p
= 0.029), D-dimer (OR 3.469, 95% CI 2.110–5.703,
p
< 0.0001), coronary artery disease (CAD) (OR 1.800, 95% CI 1.086–2.984,
p
= 0.023) and heart failure (OR 2.410 95% CI 1.385–4.193,
p
= 0.002) independently predicted thrombotic events in this population. This study suggests that the P/F ratio is associated with thrombotic events by promoting a hypercoagulation state in patients hospitalized for COVID-19.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>36650311</pmid><doi>10.1007/s11739-023-03196-w</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6542-6235</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1828-0447 |
| ispartof | Internal and emergency medicine, 2023-04, Vol.18 (3), p.889-895 |
| issn | 1828-0447 1970-9366 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9845099 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Albumin Blood glucose Cardiovascular disease Congestive heart failure Coronary artery disease Coronaviruses COVID-19 COVID-19 : diagnosis EM - Original Heart diseases Hypoxemia Hypoxia Internal Medicine management and prognosis Medicine Medicine & Public Health Population studies Thrombosis |
| title | Association between PaO2/FiO2 ratio and thrombotic events in COVID-19 patients |
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