Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities

We report that atypical protein kinase Cι (PKCι) is an oncogenic driver of glioblastoma (GBM). Deletion or inhibition of PKCι significantly impairs tumor growth and prolongs survival in murine GBM models. GBM cells expressing elevated PKCι signaling are sensitive to PKCι inhibitors, whereas those ex...

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Veröffentlicht in:	Cell reports (Cambridge) 2021-11, Vol.37 (8), p.110054-110054, Article 110054
Hauptverfasser:	Kenchappa, Rajappa S., Liu, Yi, Argenziano, Michael G., Banu, Matei A., Mladek, Ann C., West, Rita, Luu, Amanda, Quiñones-Hinojosa, Alfredo, Hambardzumyan, Dolores, Justilien, Verline, Leitges, Michael, Sarkaria, Jann N., Sims, Peter A., Canoll, Peter, Murray, Nicole R., Fields, Alan P., Rosenfeld, Steven S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinogenesis - genetics Cell Line, Tumor Disease Models, Animal Gene Expression - genetics Gene Expression Regulation, Neoplastic - genetics glioblastoma Glioblastoma - classification Glioblastoma - genetics Glioblastoma - metabolism Humans Isoenzymes - genetics Isoenzymes - metabolism kinase inhibitor Mice Oncogenes - genetics Protein Kinase C - genetics Protein Kinase C - metabolism Protein Kinase C - physiology protein kinase C iota Signal Transduction - physiology SRC
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