Ulipristal Acetate in Adenomyosis

Ulipristal Acetate in Adenomyosis

Adenomyosis is defined as the invasion of the basal endometrium (stroma and glands) into the underlying myometrium. It may lead to abnormal uterine bleeding (AUB), pelvic pain, and infertility. The definitive treatment is hysterectomy. Some conservative measures have been used in patients willing to...

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Veröffentlicht in:Gynecology and minimally invasive therapy 2022-10, Vol.11 (4), p.198-202
Hauptverfasser: Gonçalves-Henriques, Manuel, de Pinho, António, Freixo, Marília, Liz-Coelho, Maria, Castro, Fabiana, Ceschin, Nathan, Brandão, Pedro
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container_end_page 202
container_issue 4
container_start_page 198
container_title Gynecology and minimally invasive therapy
container_volume 11
creator Gonçalves-Henriques, Manuel
de Pinho, António
Freixo, Marília
Liz-Coelho, Maria
Castro, Fabiana
Ceschin, Nathan
Brandão, Pedro
description Adenomyosis is defined as the invasion of the basal endometrium (stroma and glands) into the underlying myometrium. It may lead to abnormal uterine bleeding (AUB), pelvic pain, and infertility. The definitive treatment is hysterectomy. Some conservative measures have been used in patients willing to procreate. Ulipristal acetate is a selective progesterone receptor modulator used to treat AUB caused by leiomyomas. This is a systematic review on the use of ulipristal to treat adenomyosis. Eight eligible articles were retrieved from PubMed, SCOPUS, and Cochrane Library. Only one randomized clinical trial was published until date concerning this matter. It seems that ulipristal acetate induces partial or complete remission of AUB caused by adenomyosis, but the evidence concerning its effect on pelvic pain and the radiologic findings of the disease is conflicting. Nevertheless, given the paucity of data, it is still preliminary to draw any conclusion about the subject.
doi_str_mv 10.4103/gmit.gmit_95_21
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title Ulipristal Acetate in Adenomyosis
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