Initial detachment of the mouse oocyte from the zona pellucida is mediated by metallopeptidase activity

The fully grown mammalian oocyte is tightly attached to its extracellular matrix shell, the zona pellucida (ZP), but the oocyte detaches from the ZP shortly after ovulation is signaled. The mechanism by which the oocyte detaches from the ZP is unknown. Because ZP proteins are initially secreted as t...

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Veröffentlicht in:	Biology of reproduction 2022-09, Vol.108 (1), p.81-97
Hauptverfasser:	Macaulay, Angus D., Ortman, Chyna S., Moore, Kevin R.J., Baltz, Jay M.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Animals Epitopes Epitopes - metabolism Extracellular matrix Female meiosis Membrane proteins metallopeptidase Metalloproteases - metabolism Metalloproteinase Mice oocyte Oocytes Oocytes - metabolism Ovulation Peptide Hydrolases - metabolism Proteins RESEARCH ARTICLE secretase Transcriptomes Zona pellucida Zona Pellucida - metabolism Zona Pellucida Glycoproteins - metabolism
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