Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic model

Pancreatic cancer (PC) has a poor prognosis, and most patients present with either locally advanced or distant metastatic disease. Irreversible electroporation (IRE) is a non-thermal method of ablation used clinically in locally advanced PC, but most patients eventually develop distant recurrence. W...

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Veröffentlicht in:	Journal for immunotherapy of cancer 2023-01, Vol.11 (1), p.e006133
Hauptverfasser:	Shankara Narayanan, Jayanth S, Hayashi, Tomoko, Erdem, Suna, McArdle, Sara, Tiriac, Herve, Ray, Partha, Pu, Minya, Mikulski, Zbigniew, Miller, Aaron, Messer, Karen, Carson, Dennis, Schoenberger, Stephen, White, Rebekah R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - therapeutic use Electroporation - methods Immunity Liver Neoplasms - drug therapy Male Mice Oncolytic and Local Immunotherapy Pancreatic Neoplasms Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology
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