Predictors of Mortality in COVID-19 patients: An observational study
To identify the factors that affect outcome in COVID-19 patients in the Pakistani population. A total of 225 patients of COVID-19 RT-PCR proven were included during November, 2020 to June, 2021 in this cross-sectional study. They were stratified into different disease severity categories as per WHO...
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| Veröffentlicht in: | Pakistan journal of medical sciences 2023-01, Vol.39 (1), p.241-247 |
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| creator | Qureshi, M Arsalan Toori, Kaleem Ullah Ahmed, Raja Mobeen |
| description | To identify the factors that affect outcome in COVID-19 patients in the Pakistani population.
A total of 225 patients of COVID-19 RT-PCR proven were included during November, 2020 to June, 2021 in this cross-sectional study. They were stratified into different disease severity categories as per WHO guidelines. The characteristics of survivors and non survivors were recorded and then compared to draw conclusions.
Mean age was 59 years. Majority of the patients were male (68%) and the overall mortality rate was 30.1%. The non survivors were more likely to be female, had a greater number of comorbidities, had a higher respiratory rate and lower oxygen saturations at presentation and had a greater frequency of invasive mechanical ventilation. Non survivors had higher values of TLC, CRP, D-dimers and lower values of Hemoglobin and Platelets. The non survivors had higher incidence of ARDS, Septic shock and Multiorgan involvement. A higher CURB-65 score was observed in non survivors as compared to those who survived. Multivariate analysis showed that female gender, presence of and higher number of comorbid conditions and a higher CURB-65 score was linked with mortality.
Results are compatible with international studies; increasing age, number of comorbid conditions and high inflammatory markers are associated with increased mortality. Our study had an exception that female gender had higher mortality as compared to men. |
| doi_str_mv | 10.12669/pjms.39.1.6059 |
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A total of 225 patients of COVID-19 RT-PCR proven were included during November, 2020 to June, 2021 in this cross-sectional study. They were stratified into different disease severity categories as per WHO guidelines. The characteristics of survivors and non survivors were recorded and then compared to draw conclusions.
Mean age was 59 years. Majority of the patients were male (68%) and the overall mortality rate was 30.1%. The non survivors were more likely to be female, had a greater number of comorbidities, had a higher respiratory rate and lower oxygen saturations at presentation and had a greater frequency of invasive mechanical ventilation. Non survivors had higher values of TLC, CRP, D-dimers and lower values of Hemoglobin and Platelets. The non survivors had higher incidence of ARDS, Septic shock and Multiorgan involvement. A higher CURB-65 score was observed in non survivors as compared to those who survived. Multivariate analysis showed that female gender, presence of and higher number of comorbid conditions and a higher CURB-65 score was linked with mortality.
Results are compatible with international studies; increasing age, number of comorbid conditions and high inflammatory markers are associated with increased mortality. Our study had an exception that female gender had higher mortality as compared to men.</description><identifier>ISSN: 1682-024X</identifier><identifier>EISSN: 1681-715X</identifier><identifier>DOI: 10.12669/pjms.39.1.6059</identifier><identifier>PMID: 36694783</identifier><language>eng</language><publisher>Pakistan: Knowledge Bylanes</publisher><subject>Age ; China ; COVID-19 ; Diabetes ; Females ; Fever ; Gender ; Hemoglobin ; Hospitals ; Hypertension ; Infections ; Laboratories ; Liver diseases ; Males ; Medical research ; Medicine, Experimental ; Mortality ; Neutrophils ; Observational studies ; Original ; Oxygen saturation ; Pakistan ; Pandemics ; Patients ; Pneumonia ; Regression analysis ; Respiration ; Respiratory diseases ; Respiratory distress syndrome ; Sepsis ; Ventilators</subject><ispartof>Pakistan journal of medical sciences, 2023-01, Vol.39 (1), p.241-247</ispartof><rights>Copyright: © Pakistan Journal of Medical Sciences.</rights><rights>COPYRIGHT 2023 Knowledge Bylanes</rights><rights>(c)2023 Pakistan Journal of Medical Sciences</rights><rights>Copyright: © Pakistan Journal of Medical Sciences 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843027/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843027/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36694783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qureshi, M Arsalan</creatorcontrib><creatorcontrib>Toori, Kaleem Ullah</creatorcontrib><creatorcontrib>Ahmed, Raja Mobeen</creatorcontrib><title>Predictors of Mortality in COVID-19 patients: An observational study</title><title>Pakistan journal of medical sciences</title><addtitle>Pak J Med Sci</addtitle><description>To identify the factors that affect outcome in COVID-19 patients in the Pakistani population.
A total of 225 patients of COVID-19 RT-PCR proven were included during November, 2020 to June, 2021 in this cross-sectional study. They were stratified into different disease severity categories as per WHO guidelines. The characteristics of survivors and non survivors were recorded and then compared to draw conclusions.
Mean age was 59 years. Majority of the patients were male (68%) and the overall mortality rate was 30.1%. The non survivors were more likely to be female, had a greater number of comorbidities, had a higher respiratory rate and lower oxygen saturations at presentation and had a greater frequency of invasive mechanical ventilation. Non survivors had higher values of TLC, CRP, D-dimers and lower values of Hemoglobin and Platelets. The non survivors had higher incidence of ARDS, Septic shock and Multiorgan involvement. A higher CURB-65 score was observed in non survivors as compared to those who survived. Multivariate analysis showed that female gender, presence of and higher number of comorbid conditions and a higher CURB-65 score was linked with mortality.
Results are compatible with international studies; increasing age, number of comorbid conditions and high inflammatory markers are associated with increased mortality. Our study had an exception that female gender had higher mortality as compared to men.</description><subject>Age</subject><subject>China</subject><subject>COVID-19</subject><subject>Diabetes</subject><subject>Females</subject><subject>Fever</subject><subject>Gender</subject><subject>Hemoglobin</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Liver diseases</subject><subject>Males</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mortality</subject><subject>Neutrophils</subject><subject>Observational studies</subject><subject>Original</subject><subject>Oxygen saturation</subject><subject>Pakistan</subject><subject>Pandemics</subject><subject>Patients</subject><subject>Pneumonia</subject><subject>Regression analysis</subject><subject>Respiration</subject><subject>Respiratory diseases</subject><subject>Respiratory distress syndrome</subject><subject>Sepsis</subject><subject>Ventilators</subject><issn>1682-024X</issn><issn>1681-715X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptks9rFDEcxQdRbK2evcmAIF5mmm9-TCYehGVbtVCpB5XeQmYm6WbJTLZJprD_fbNtrV2RHBKSz3tJHq8o3gKqATeNON6sx1gTUUPdICaeFYfQtFBxYJfP79a4QpheHhSvYlwjRBvK8MvigGQp5S05LE5-BD3YPvkQS2_K7z4k5WzalnYqlxe_z04qEOVGJaunFD-Vi6n0XdThJu_4SbkypnnYvi5eGOWifvMwHxW_vpz-XH6rzi--ni0X51VPCU6V6IAhoREVRmE2KCKGgXE-ALSgDeaaC44N64ASYpCgAyBlQCtMDQViOnJUfL733czdqIc-vykoJzfBjipspVdW7p9MdiWv_I0ULSUI82zw8cEg-OtZxyRHG3vtnJq0n6PEvBFMZFRk9P0_6NrPIX85Uy1uMMlZNn-pK-W0tJPx-d5-ZyoXnBHEACHIVP0fKo9Bj7b3kzY27-8JPjwRrLRyaRW9m3ehx33w-B7sg48xaPMYBiB51xC5a4gkQoLcNSQr3j3N8JH_UwlyCz6gtI8</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Qureshi, M Arsalan</creator><creator>Toori, Kaleem Ullah</creator><creator>Ahmed, Raja Mobeen</creator><general>Knowledge Bylanes</general><general>AsiaNet Pakistan (Pvt) Ltd</general><general>Professional Medical Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230101</creationdate><title>Predictors of Mortality in COVID-19 patients: An observational study</title><author>Qureshi, M Arsalan ; Toori, Kaleem Ullah ; Ahmed, Raja Mobeen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-9b1509e049fa25da39dd577d1181ef27e7972f5b1433f094d10af1ea24f413fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Age</topic><topic>China</topic><topic>COVID-19</topic><topic>Diabetes</topic><topic>Females</topic><topic>Fever</topic><topic>Gender</topic><topic>Hemoglobin</topic><topic>Hospitals</topic><topic>Hypertension</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Liver diseases</topic><topic>Males</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Mortality</topic><topic>Neutrophils</topic><topic>Observational studies</topic><topic>Original</topic><topic>Oxygen saturation</topic><topic>Pakistan</topic><topic>Pandemics</topic><topic>Patients</topic><topic>Pneumonia</topic><topic>Regression analysis</topic><topic>Respiration</topic><topic>Respiratory diseases</topic><topic>Respiratory distress syndrome</topic><topic>Sepsis</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qureshi, M Arsalan</creatorcontrib><creatorcontrib>Toori, Kaleem Ullah</creatorcontrib><creatorcontrib>Ahmed, Raja Mobeen</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pakistan journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qureshi, M Arsalan</au><au>Toori, Kaleem Ullah</au><au>Ahmed, Raja Mobeen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of Mortality in COVID-19 patients: An observational study</atitle><jtitle>Pakistan journal of medical sciences</jtitle><addtitle>Pak J Med Sci</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>39</volume><issue>1</issue><spage>241</spage><epage>247</epage><pages>241-247</pages><issn>1682-024X</issn><eissn>1681-715X</eissn><abstract>To identify the factors that affect outcome in COVID-19 patients in the Pakistani population.
A total of 225 patients of COVID-19 RT-PCR proven were included during November, 2020 to June, 2021 in this cross-sectional study. They were stratified into different disease severity categories as per WHO guidelines. The characteristics of survivors and non survivors were recorded and then compared to draw conclusions.
Mean age was 59 years. Majority of the patients were male (68%) and the overall mortality rate was 30.1%. The non survivors were more likely to be female, had a greater number of comorbidities, had a higher respiratory rate and lower oxygen saturations at presentation and had a greater frequency of invasive mechanical ventilation. Non survivors had higher values of TLC, CRP, D-dimers and lower values of Hemoglobin and Platelets. The non survivors had higher incidence of ARDS, Septic shock and Multiorgan involvement. A higher CURB-65 score was observed in non survivors as compared to those who survived. Multivariate analysis showed that female gender, presence of and higher number of comorbid conditions and a higher CURB-65 score was linked with mortality.
Results are compatible with international studies; increasing age, number of comorbid conditions and high inflammatory markers are associated with increased mortality. Our study had an exception that female gender had higher mortality as compared to men.</abstract><cop>Pakistan</cop><pub>Knowledge Bylanes</pub><pmid>36694783</pmid><doi>10.12669/pjms.39.1.6059</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age China COVID-19 Diabetes Females Fever Gender Hemoglobin Hospitals Hypertension Infections Laboratories Liver diseases Males Medical research Medicine, Experimental Mortality Neutrophils Observational studies Original Oxygen saturation Pakistan Pandemics Patients Pneumonia Regression analysis Respiration Respiratory diseases Respiratory distress syndrome Sepsis Ventilators |
| title | Predictors of Mortality in COVID-19 patients: An observational study |
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